106 - Vigorous Intensity Intervals and Moderate Intensity Exercise Have Similar Postexercise Impacts on Blood Glucose in Trained Young Adults With Type 1 Diabetes

2019 ◽  
Vol 43 (7) ◽  
pp. S38
Author(s):  
Andrea Macintosh ◽  
Jacqueline L. Hay ◽  
Dessi P. Zaharieva ◽  
Veronica Jamnik ◽  
Michael C. Riddell ◽  
...  
Keyword(s):  
Type 1 Diabetes ◽  
Young Adults ◽  
Blood Glucose ◽  
Moderate Intensity ◽  
Moderate Intensity Exercise ◽  
Vigorous Intensity

scholarly journals The Effect of a Short Sprint on Postexercise Whole-Body Glucose Production and Utilization Rates in Individuals with Type 1 Diabetes Mellitus

2012 ◽  
Vol 97 (11) ◽  
pp. 4193-4200 ◽  
Author(s):  
A. J. Fahey ◽  
N. Paramalingam ◽  
R. J. Davey ◽  
E. A. Davis ◽  
T. W. Jones ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Type 1 Diabetes ◽  
Blood Glucose ◽  
Type 1 Diabetes Mellitus ◽  
Whole Body ◽  
Moderate Intensity ◽  
Moderate Intensity Exercise ◽  
Glucose Levels ◽  
Blood Glucose Levels

Context: Recently we showed that a 10-sec maximal sprint effort performed before or after moderate intensity exercise can prevent early hypoglycemia during recovery in individuals with type 1 diabetes mellitus (T1DM). However, the mechanisms underlying this protective effect of sprinting are still unknown. Objective: The objective of the study was to test the hypothesis that short duration sprinting increases blood glucose levels via a disproportionate increase in glucose rate of appearance (Ra) relative to glucose rate of disappearance (Rd). Subjects and Experimental Design: Eight T1DM participants were subjected to a euglycemic-euinsulinemic clamp and, together with nondiabetic participants, were infused with [6,6-2H]glucose before sprinting for 10 sec and allowed to recover for 2 h. Results: In response to sprinting, blood glucose levels increased by 1.2 ± 0.2 mmol/liter (P < 0.05) within 30 min of recovery in T1DM participants and remained stable afterward, whereas glycemia rose by only 0.40 ± 0.05 mmol/liter in the nondiabetic group. During recovery, glucose Ra did not change in both groups (P > 0.05), but glucose Rd in the nondiabetic and diabetic participants fell rapidly after exercise before returning within 30 min to preexercise levels. After sprinting, the levels of plasma epinephrine, norepinephrine, and GH rose transiently in both experimental groups (P < 0.05). Conclusion: A sprint as short as 10 sec can increase plasma glucose levels in nondiabetic and T1DM individuals, with this rise resulting from a transient decline in glucose Rd rather than from a disproportionate rise in glucose Ra relative to glucose Rd as reported with intense aerobic exercise.

Delayed hypoglycaemia in people with type 1 diabetes after performing moderate intensity exercise before the evening meal

2015 ◽  
Vol 32 (3) ◽  
pp. 99-102 ◽  
Author(s):  
Jacqui Charlton ◽  
Lynn Kilbride ◽  
Rory MacLean ◽  
Mark G Darlison ◽  
John McKnight
Keyword(s):  
Type 1 Diabetes ◽  
Moderate Intensity ◽  
Evening Meal ◽  
Moderate Intensity Exercise

scholarly journals Moderate intensity exercise in hypoxia increases IGF-1 bioavailability and serum irisin in individuals with type 1 diabetes

2020 ◽  
Vol 11 ◽  
pp. 204201882092532 ◽  
Author(s):  
Aleksandra Żebrowska ◽  
Marcin Sikora ◽  
Anna Konarska ◽  
Anna Zwierzchowska ◽  
Tomasz Kamiński ◽  
...  
Keyword(s):  
Type 1 Diabetes ◽  
Serum Levels ◽  
Cycle Ergometer ◽  
Moderate Intensity ◽  
Moderate Intensity Exercise ◽  
Physiological Variables ◽  
Hypoxic Conditions ◽  
Study Results ◽  
Glycaemia Control

Aim: This study aimed to determine the effect of moderate intensity continuous exercise (Ex) and hypoxia (Hyp) on serum brain-derived neurotrophic factor (BDNF), insulin-like growth factor-1 (IGF-1) and its binding protein-3 (IGFBP-3), irisin and cytokines levels in patients with type 1 diabetes (T1D). Methods: A total of 14 individuals with T1D (age: 28.7 ± 7.3 years) and 14 healthy adults (age: 27.1 ± 3.9 years) performed 40-min continuous Ex at moderate intensity (50% lactate threshold) on a cycle ergometer in normoxia (Nor) and Hyp (FiO2 = 15.1%) Biochemical factors, glucose concentrations and physiological variables were measured at rest, immediately and up to 24 h after both Ex protocols. Results: Patients with T1D had significantly lower pre-Ex serum concentrations of BDNF ( p < 0.05, p < 0.01), and total IGF-1 ( p < 0.001, p < 0.05) and significantly higher irisin levels ( p < 0.05, p < 0.01) in Nor and Hyp, compared with healthy subjects. Ex significantly increased in T1D group serum BDNF (in Nor only p < 0.05) and total IGF-1 levels in Nor and Hyp ( p < 0.001 and p < 0.01, respectively). Immediately after Ex in Hyp, freeIGF-1 ( p < 0.05) and irisin levels ( p < 0.001) were significantly higher compared with the levels induced by Ex alone. Free IGF-1 and irisin serum levels remained elevated in 24 h post-Ex in Hyp. In T1D, significant blood glucose (BG) decrease was observed immediately after Ex in Hyp ( p < 0.001) and in 24 h recovery ( p < 0.001) compared with pre-Ex level. Conclusion: The study results suggest that moderate intensity continuous Ex has beneficial effect on BDNF and IGF-1 levels. Ex in hypoxic conditions may be more effective in increasing availability of IGF-1. The alterations in the post-Ex irisin levels and IGF-1 system may be contributing to more effective glycaemia control in patients with T1D.

scholarly journals Levels and Patterns of Physical Activity in Children and Adolescents With Type 1 Diabetes and Associated Metabolic and Physiologic Health Outcomes

2010 ◽  
Vol 7 (1) ◽  
pp. 68-77 ◽  
Author(s):  
Sarah Edmunds ◽  
Denise Roche ◽  
Gareth Stratton
Keyword(s):  
Physical Activity ◽  
Type 1 Diabetes ◽  
Health Outcomes ◽  
Children And Adolescents ◽  
Moderate Intensity ◽  
Insulin Dosage ◽  
Current Recommendation ◽  
Health Gains ◽  
Vigorous Intensity

Background:The current study objectively assessed physical activity (PA) levels and patterns in children and adolescents with type 1 diabetes and compared the metabolic and physiologic health profiles of those achieving and those not achieving the current recommendation of 60 minutes a day (minutes·D−1) of at least moderate intensity PA.Method:37 children and adolescents (20 boys, 17 girls) aged 12.7 ± 2.1 years (mean ± SD), disease duration 5.9 ± 3.0 years participated. PA was assessed using heart rate monitoring. Peak VO2, BMI, sum of 5 skinfolds, HbA1c, and daily insulin dosage were also determined.Results:Mean accumulated time in moderate-to-vigorous intensity PA was 53.6 ± 31.4 minutes·D−1. Levels of vigorous-intensity PA were low, mean 8.3 ± 10.2 minutes·D−1. When controlling for age, no differences in metabolic or physiologic health outcomes were evident between those individuals achieving, and those not achieving, 60 minutes·D−1 of moderate-to-vigorous intensity PA. PA predominantly occurred in short bouts lasting 5 minutes or less.Conclusion:The efficacy of accumulating 60 minutes·D−1 of moderate-to-vigorous intensity PA, in the form of short duration, intermittent bouts of largely unplanned PA, to promote health gains in children and adolescents with type 1 diabetes is questionable.

Self-care Behaviour and Blood Glucose Control in Young Adults With Type 1 Diabetes Mellitus

1993 ◽  
Vol 10 (1) ◽  
pp. 74-80 ◽  
Author(s):  
Robert Peveler ◽  
B.A. Davies ◽  
R.A. Mayou ◽  
C.G. Fairburn ◽  
J.I. Mann
Keyword(s):  
Diabetes Mellitus ◽  
Type 1 Diabetes ◽  
Young Adults ◽  
Blood Glucose ◽  
Type 1 Diabetes Mellitus ◽  
Glucose Control ◽  
Blood Glucose Control ◽  
Self Care

Moderate-intensity Exercise Training in Sole and Simultaneous Forms with Insulin Ameliorates the Experimental Type 1 Diabetes-induced Intrinsic Apoptosis in Testicular Tissue

2019 ◽  
Vol 40 (14) ◽  
pp. 909-920 ◽  
Author(s):  
Zahra Samadian ◽  
Javad Tolouei Azar ◽  
Sana Moshari ◽  
Mazdak Razi ◽  
Asghar Tofighi
Keyword(s):  
Type 1 Diabetes ◽  
Exercise Training ◽  
Caspase 3 ◽  
Moderate Intensity ◽  
Tunel Staining ◽  
Intrinsic Apoptosis ◽  
Moderate Intensity Exercise ◽  
Experimental Type ◽  
Induced Apoptosis

AbstractThe aim of this study was to investigate the ameliorative effect of moderate-intensity exercise training in sole and simultaneous forms with insulin on experimental type 1 diabetes (T1D)-induced apoptosis. A total of 36 mature male Wistar rats were divided into six equally sized groups, including sedentary control (Con), moderate-intensity exercise training (E-sole), sedentary T1D-induced (D-sole), moderate-exercise-trained T1D-induced (DE), insulin-treated sedentary T1D-induced (DI) and exercise-trained, and insulin-treated T1D-induced (DEI) groups. The 6-week exercise training intervention was involved 30 min of moderate-intensity running on a treadmill once daily (5 days/week). Next, tubular differentiation (TDI) and spermiogenesis (SPI) indices were assessed. The Bcl-2, Bax and caspase-3 expressions were determined using RT-PCR, immunohistochemistry and western blot techniques. Finally, the TUNEL staining was used to analyze the apoptosis ratio. The moderate-intensity exercise training in the sole and when simultaneously considered with insulin (DEI) maintained testicular cellularity, up-regulated Bcl-2 expression, reduced Bax expression and ameliorated the diabetes-induced apoptosis. We failed to show remarkable alterations in caspase-3 mRNA and protein levels in the DE group versus D-sole animals. In conclusion, the moderate-intensity exercise training is able to potentially protect testicular cells from T1D-induced intrinsic apoptosis via up-regulating Bcl-2 and downregulating Bax expressions. Moreover, it amplifies the insulin-induced anti-apoptotic impacts.

Analysis of glycemic safety of a moderate-intensity resistance exercise session in patients with diabetes type 1

2020 ◽  
Vol 19 (1) ◽  
pp. 16
Author(s):  
Leandro Paim Da Cruz Carvalho ◽  
Samira Socorro Nunes De Souza ◽  
Djenane Cristovam Souza ◽  
Flávio De Souza Araujo ◽  
Ferdinando Oliveira Carvalho ◽  
...  
Keyword(s):  
Type 1 Diabetes ◽  
Blood Glucose ◽  
Physical Exercise ◽  
Resistance Exercise ◽  
Repeated Measures ◽  
Pancreatic Beta Cells ◽  
Moderate Intensity ◽  
Exercise Session ◽  
Resistance Exercise Session

 Introduction: Type 1 diabetes is an autoimmune disease that results in the destruction of pancreatic beta cells, implying the use of insulin therapy to maintain adequate blood glucose levels. When stimulated by physical exercise, glycemic homeostasis becomes impaired, providing complications in the daily lives of this population, constituting a barrier to physical exercise practice. Objective: To evaluate the glycemic safety of a resistance exercise session of moderate intensity in people with type 1 diabetes. Methods: 12 people with type 1 diabetes (7 men), performed a resistance exercise session of moderate intensity at 60% of 1 RM consisting of 7 exercises. Capillary blood glucose was assessed at the pre-session (GP), immediately after (G IA) and 20 minutes after (G 20). ANOVA for repeated measures was performed (p <0.05). Results: In the absolute values of glycemia, no significant differences were found (P = 0.061). However, when checking the delta blood glucose variation, a difference was found between G IA and G20 vs GP (P <0.05). Clinically important reductions above 20mg / dl (PI: ~ 37mg / dl; 20P: ~ 45mg / dl) without providing hypoglycemia. Conclusion: A moderate-intensity resistance exercise session proved to be safe from a glycemic point of view in people with type 1 diabetes.Keywords: diabetes mellitus type 1, resistance training, exercise. 

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