Control of osteoblast cell behavior by microcontact printed extracellular matrix protein patterns for bone tissue engineering

2013 ◽  
Vol 172 (1) ◽  
pp. e125-e126
Author(s):  
Changjiang Pan ◽  
Yudong Nie ◽  
Hongyan Ding ◽  
Yunxiao Dong
Keyword(s):  
Tissue Engineering ◽  
Extracellular Matrix ◽  
Bone Tissue Engineering ◽  
Bone Tissue ◽  
Matrix Protein ◽  
Extracellular Matrix Protein ◽  
Cell Behavior ◽  
Osteoblast Cell ◽  
Protein Patterns

Tissue Engineering: Stable Extracellular Matrix Protein Patterns Guide the Orientation of Osteoblast-like Cells (Adv. Funct. Mater. 21/2011)

2011 ◽  
Vol 21 (21) ◽  
pp. 4199-4199
Author(s):  
Jian-Tao Zhang ◽  
Juequan Nie ◽  
Mike Mühlstädt ◽  
Hilary Gallagher ◽  
Oliver Pullig ◽  
...  
Keyword(s):  
Tissue Engineering ◽  
Extracellular Matrix ◽  
Matrix Protein ◽  
Extracellular Matrix Protein ◽  
Protein Patterns

scholarly journals Cell-secreted extracellular matrix, independent of cell source, promotes the osteogenic differentiation of human stromal vascular fraction

2018 ◽  
Vol 6 (24) ◽  
pp. 4104-4115 ◽  
Author(s):  
Jenna N. Harvestine ◽  
Hakan Orbay ◽  
Jonathan Y. Chen ◽  
David E. Sahar ◽  
J. Kent Leach
Keyword(s):  
Tissue Engineering ◽  
Extracellular Matrix ◽  
Bone Tissue Engineering ◽  
Osteogenic Differentiation ◽  
Bone Tissue ◽  
Stromal Vascular Fraction ◽  
Cell Source

Cell-secreted extracellular matrix potentiates osteogenic differentiation by stromal vascular fraction for bone tissue engineering.

scholarly journals Fabrication of Decellularized Engineered Extracellular Matrix through Bioreactor-Based Environment for Bone Tissue Engineering

ACS Omega ◽  
2020 ◽  
Vol 5 (49) ◽  
pp. 31943-31956
Author(s):  
Hanieh Nokhbatolfoghahaei ◽  
Zahrasadat Paknejad ◽  
Mahboubeh Bohlouli ◽  
Maryam Rezai Rad ◽  
Pouyan Aminishakib ◽  
...  
Keyword(s):  
Tissue Engineering ◽  
Extracellular Matrix ◽  
Bone Tissue Engineering ◽  
Bone Tissue

scholarly journals An ECM-Mimicking, Mesenchymal Stem Cell-Embedded Hybrid Scaffold for Bone Regeneration

2017 ◽  
Vol 2017 ◽  
pp. 1-12 ◽  
Author(s):  
Jozafina Haj ◽  
Tharwat Haj Khalil ◽  
Mizied Falah ◽  
Eyal Zussman ◽  
Samer Srouji
Keyword(s):  
Tissue Engineering ◽  
Extracellular Matrix ◽  
Bone Tissue Engineering ◽  
Bone Regeneration ◽  
Bone Tissue ◽  
Bone Repair ◽  
Dorsal Side ◽  
Human Mscs ◽  
Hybrid Scaffold

While biologically feasible, bone repair is often inadequate, particularly in cases of large defects. The search for effective bone regeneration strategies has led to the emergence of bone tissue engineering (TE) techniques. When integrating electrospinning techniques, scaffolds featuring randomly oriented or aligned fibers, characteristic of the extracellular matrix (ECM), can be fabricated. In parallel, mesenchymal stem cells (MSCs), which are capable of both self-renewing and differentiating into numerous tissue types, have been suggested to be a suitable option for cell-based tissue engineering therapies. This work aimed to create a novel biocompatible hybrid scaffold composed of electrospun polymeric nanofibers combined with osteoconductive ceramics, loaded with human MSCs, to yield a tissue-like construct to promote in vivo bone formation. Characterization of the cell-embedded scaffolds demonstrated their resemblance to bone tissue extracellular matrix, on both micro- and nanoscales and MSC viability and integration within the electrospun nanofibers. Subcutaneous implantation of the cell-embedded scaffolds in the dorsal side of mice led to new bone, muscle, adipose, and connective tissue formation within 8 weeks. This hybrid scaffold may represent a step forward in the pursuit of advanced bone tissue engineering scaffolds.

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