silk fibroin
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2022 ◽  
Vol 26 ◽  
pp. 101273
Author(s):  
Jing Xiang ◽  
Yuzhou Li ◽  
Mingxing Ren ◽  
Ping He ◽  
Fengyi Liu ◽  
...  

2022 ◽  
Vol 74 ◽  
pp. 14-27
Author(s):  
Zhengjian Wang ◽  
Xichun Luo ◽  
Jining Sun ◽  
Philipp Seib ◽  
Suttinee Phuagkhaopong ◽  
...  

2022 ◽  
Vol 89 ◽  
pp. 104942
Author(s):  
Siyuan Yao ◽  
Zheng Xu ◽  
Song Chen ◽  
Yue Meng ◽  
Yue Xue ◽  
...  

Gels ◽  
2022 ◽  
Vol 8 (1) ◽  
pp. 56
Author(s):  
Hongdou Shen ◽  
Pei Wang ◽  
Xiaoke Han ◽  
Mengli Ma ◽  
Yinghui Shang ◽  
...  

Promising wound dressings can achieve rapid soft-tissue filling while refactoring the biochemical and biophysical microenvironment to recruit endogenous cells, facilitating tissue healing, integration, and regeneration. In this study, a tissue biomolecule-responsive hydrogel matrix, employing natural silk fibroin (SF) as a functional biopolymer and haemoglobin (Hb) as a peroxidase-like biocatalyst, was fabricated through cascade enzymatic crosslinking. The hydrogels possessed mechanical tunability and displayed adjustable gelation times. A tyrosine unit on SF stabilised the structure of Hb during the cascade oxidation process; thus, the immobilized Hb in SF hydrogels exhibited higher biocatalytic efficiency than the free enzyme system, which provided a continuously antioxidative system. The regulation of the dual enzyme ratio endowed the hydrogels with favourable biocompatibility, biodegradability, and adhesion strength. These multifunctional hydrogels provided a three-dimensional porous extracellular matrix-like microenvironment for promoting cell adhesion and proliferation. A rat model with a full-thickness skin defect revealed accelerated wound regeneration via collagen deposition, re-epithelialisation and revascularisation. Enzyme-loaded hydrogels are an attractive and high-safety biofilling material with the potential for wound healing, tissue regeneration, and haemostasis.


2022 ◽  
pp. 2105420
Author(s):  
Woojin Choi ◽  
Deokjae Heo ◽  
Taeho Kim ◽  
Sungwon Jung ◽  
Moonhyun Choi ◽  
...  
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