Destruction of valsartan using electrochemical and electrochemical/persulfate process. Kinetics, identification of degradation pathway and application in aqueous matrices

2021 ◽  
Vol 9 (5) ◽  
pp. 106265
Author(s):  
Olga S. Arvaniti ◽  
Ioannis Konstantinou ◽  
Dionissios Mantzavinos ◽  
Zacharias Frontistis
Keyword(s):  
Degradation Pathway ◽  
Process Kinetics ◽  
Aqueous Matrices

Degradation of tetracycline by UV activated monochloramine process: Kinetics, degradation pathway, DBPs formation and toxicity assessment

2020 ◽  
Vol 395 ◽  
pp. 125090 ◽  
Author(s):  
Anhong Cai ◽  
Jing Deng ◽  
Mengyuan Xu ◽  
Tianxin Zhu ◽  
Shiqing Zhou ◽  
...  
Keyword(s):  
Degradation Pathway ◽  
Toxicity Assessment ◽  
Process Kinetics

scholarly journals DEET degradation in UV/monochloramine process: Kinetics, degradation pathway, toxicity and energy consumption analysis

Chemosphere ◽  
2020 ◽  
Vol 255 ◽  
pp. 126962 ◽  
Author(s):  
Tianxin Zhu ◽  
Jing Deng ◽  
Mengyuan Xu ◽  
Anhong Cai ◽  
Cheng Ye ◽  
...  
Keyword(s):  
Energy Consumption ◽  
Degradation Pathway ◽  
Process Kinetics ◽  
Energy Consumption Analysis

Mitochondria Associated Degradation Pathway (MAD) Function Beyond the Outer Membrane

2019 ◽  
Author(s):  
Pin-Chao Liao ◽  
Dana Alessi Wolken ◽  
Edith Serrano ◽  
Pallavi Srivastava ◽  
Liza A. Pon
Keyword(s):  
Outer Membrane ◽  
Degradation Pathway

Corticosteroid Catabolism by Klebsiella pneumoniae as a Possible Mechanism for Increased Pneumonia Risk

2019 ◽  
Vol 20 (4) ◽  
pp. 309-316 ◽  
Author(s):  
Pritam Chattopadhyay ◽  
Goutam Banerjee
Keyword(s):  
Amino Acid ◽  
Klebsiella Pneumoniae ◽  
Kegg Pathway ◽  
Degradation Pathway ◽  
Amino Acid Sequences ◽  
Biological Mechanism ◽  
Clinical Strains ◽  
Catabolism Pathway ◽  
Steroid Catabolism ◽  
Nutrition Source

Background: Several strains of Klebsiella pneumoniae are responsible for causing pneumonia in lung and thereby causing death in immune-suppressed patients. In recent year, few investigations have reported the enhancement of K. pneumoniae population in patients using corticosteroid containing inhaler. Objectives: The biological mechanism(s) behind this increased incidence has not been elucidated. Therefore, the objective of this investigating was to explore the relation between Klebsiella pneumoniae and increment in carbapenamase producing Enterobacteriaceae score (ICS). Methods: The available genomes of K. pneumoniae and the amino acid sequences of steroid catabolism pathway enzymes were taken from NCBI database and KEGG pathway tagged with UniPort database, respectively. We have used different BLAST algorithms (tBLASTn, BLASTp, psiBLAST, and delBLAST) to identify enzymes (by their amino acid sequence) involved in steroid catabolism. Results: A total of 13 enzymes (taken from different bacterial candidates) responsible for corticosteroid degradation have been identified in the genome of K. pneumoniae. Finally, 8 enzymes (K. pneumoniae specific) were detected in four clinical strains of K. pneumoniae. This investigation intimates that this ability to catabolize corticosteroids could potentially be one mechanism behind the increased pneumonia incidence. Conclusion: The presence of corticosteroid catabolism enzymes in K. pneumoniae enhances the ability to utilize corticosteroid for their own nutrition source. This is the first report to demonstrate the corticosteroid degradation pathway in clinical strains of K. pneumoniae.

Evaluation of Process Kinetics and Toxicity on Granular Activated Sludge

2017 ◽  
Vol 2017 (3) ◽  
pp. 484-491
Author(s):  
Sunayna Dasgupta ◽  
Ananda Shankar Bhattacharjee ◽  
Ramesh Goel
Keyword(s):  
Activated Sludge ◽  
Process Kinetics

UV/H2O2 oxidation of tri(2-chloroethyl) phosphate: Intermediate products, degradation pathway and toxicity evaluation

2020 ◽  
Vol 98 ◽  
pp. 55-61 ◽  
Author(s):  
Qiuyi Ji ◽  
Huan He ◽  
Zhanqi Gao ◽  
Xiaohan Wang ◽  
Shaogui Yang ◽  
...  
Keyword(s):  
Degradation Pathway ◽  
Toxicity Evaluation ◽  
Intermediate Products ◽  
H2o2 Oxidation

scholarly journals Further Studies on the 3-Ketosteroid 9α-Hydroxylase of Rhodococcus ruber Chol-4, a Rieske Oxygenase of the Steroid Degradation Pathway

2021 ◽  
Vol 9 (6) ◽  
pp. 1171
Author(s):  
Sara Baldanta ◽  
Juana María Navarro Llorens ◽  
Govinda Guevara
Keyword(s):  
Cholesterol Metabolism ◽  
Genetic Regulation ◽  
Degradation Pathway ◽  
Rhodococcus Ruber ◽  
Promoter Regions ◽  
Steroid Nucleus ◽  
Steroid Substrate ◽  
Fine Regulation ◽  
Rieske Oxygenase ◽  
Steroid Catabolism

The biochemistry and genetics of the bacterial steroid catabolism have been extensively studied during the last years and their findings have been essential to the development of biotechnological applications. For instance, metabolic engineering of the steroid-eater strains has allowed to obtain intermediaries of industrial value. However, there are still some drawbacks that must be overcome, such as the redundancy of the steroid catabolism genes in the genome and a better knowledge of its genetic regulation. KshABs and KstDs are key enzymes involved in the aerobic breakage of the steroid nucleus. Rhodococcus ruber Chol-4 contains three kshAs genes, a single kshB gene and three kstDs genes within its genome. In the present work, the growth of R. ruber ΔkshA strains was evaluated on different steroids substrates; the promoter regions of these genes were analyzed; and their expression was followed by qRT-PCR in both wild type and ksh mutants. Additionally, the transcription level of the kstDs genes was studied in the ksh mutants. The results show that KshA2B and KshA1B are involved in AD metabolism, while KshA3B and KshA1B contribute to the cholesterol metabolism in R. ruber. In the kshA single mutants, expression of the remaining kshA and kstD genes is re-organized to survive on the steroid substrate. These data give insight into the fine regulation of steroid genes when several isoforms are present.

scholarly journals Enhanced Autophagic Activity Improved the Root Growth and Nitrogen Utilization Ability of Apple Plants under Nitrogen Starvation

2021 ◽  
Vol 22 (15) ◽  
pp. 8085
Author(s):  
Liuqing Huo ◽  
Zijian Guo ◽  
Qi Wang ◽  
Li Cheng ◽  
Xin Jia ◽  
...  
Keyword(s):  
Transgenic Plants ◽  
Root Growth ◽  
Nitrogen Starvation ◽  
Degradation Pathway ◽  
Physiological Status ◽  
Hydroponic System ◽  
Nitrogen Levels ◽  
Nitrogen Concentrations ◽  
Nitrogen Nutrients ◽  
Autophagic Activity

Autophagy is a conserved degradation pathway for recycling damaged organelles and aberrant proteins, and its important roles in plant adaptation to nutrient starvation have been generally reported. Previous studies found that overexpression of autophagy-related (ATG) gene MdATG10 enhanced the autophagic activity in apple roots and promoted their salt tolerance. The MdATG10 expression was induced by nitrogen depletion condition in both leaves and roots of apple plants. This study aimed to investigate the differences in the growth and physiological status between wild type and MdATG10-overexpressing apple plants in response to nitrogen starvation. A hydroponic system containing different nitrogen levels was used. The study found that the reduction in growth and nitrogen concentrations in different tissues caused by nitrogen starvation was relieved by MdATG10 overexpression. Further studies demonstrated the increased root growth and the higher nitrogen absorption and assimilation ability of transgenic plants. These characteristics contributed to the increased uptake of limited nitrogen nutrients by transgenic plants, which also reduced the starvation damage to the chloroplasts. Therefore, the MdATG10-overexpressing apple plants could maintain higher photosynthetic ability and possess better growth under nitrogen starvation stress.

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