Formation of Kiss1R/GPER Heterocomplexes Negatively Regulates Kiss1R-mediated Signalling through Limiting Receptor Cell Surface Expression

2021 ◽  
Vol 433 (7) ◽  
pp. 166843
Author(s):  
Ran Ke ◽  
Samson Ian Sam Lok ◽  
Kailash Singh ◽  
Billy Kwok Chong Chow ◽  
Harald Janovjak ◽  
...  
Keyword(s):  
Cell Surface ◽  
Receptor Cell ◽  
Surface Expression ◽  
Cell Surface Expression

scholarly journals Regulation of GIP and GLP1 Receptor Cell Surface Expression by N-Glycosylation and Receptor Heteromerization

PLoS ONE ◽  
2012 ◽  
Vol 7 (3) ◽  
pp. e32675 ◽  
Author(s):  
Gina M. Whitaker ◽  
Francis C. Lynn ◽  
Christopher H. S. McIntosh ◽  
Eric A. Accili
Keyword(s):  
Cell Surface ◽  
Receptor Cell ◽  
Surface Expression ◽  
Cell Surface Expression

scholarly journals Individual cells traffic the Vasopressin 2 Receptor to their cell surface with different success

2021 ◽  
Author(s):  
Eline J Koers ◽  
Bradley A Morgan ◽  
Iain B Styles ◽  
Dmitry J Veprintsev
Keyword(s):  
Cell Surface ◽  
Receptor Cell ◽  
Surface Expression ◽  
G Protein Coupled Receptors ◽  
Cell Surface Expression ◽  
Subcellular Localisation ◽  
Equal Distribution ◽  
Mutant Receptors ◽  
G Protein Coupled ◽  
Correct Expression

G protein coupled receptors (GPCRs) translate the actions of hormones and neurotransmitters into intracellular signalling events. Mutations in GPCRs can prevent their correct expression and trafficking to the cell surface and cause disease. Single cell subcellular localisation measurements reveal that while some cells appear to traffic the majority of the vasopressin 2 receptor (V2R) molecules to the cell surface, others retain a greater number of receptors in the ER or have approximately equal distribution. Mutations in the V2R affect the proportion of cells able to send this GPCR to their cell surface but surprisingly they do not prevent all cells from correctly trafficking the mutant receptors. These findings reveal the potential for rescue of mutant receptor cell surface expression by pharmacological manipulation of the GPCR folding and trafficking machinery.

CLIC4 interacts with histamine H3 receptor and enhances the receptor cell surface expression

2008 ◽  
Vol 369 (2) ◽  
pp. 603-608 ◽  
Author(s):  
Kay Maeda ◽  
Mitsuya Haraguchi ◽  
Atsuo Kuramasu ◽  
Takeya Sato ◽  
Kyohei Ariake ◽  
...  
Keyword(s):  
Cell Surface ◽  
Receptor Cell ◽  
Surface Expression ◽  
Cell Surface Expression ◽  
Histamine H3 Receptor ◽  
H3 Receptor ◽  
Histamine H3

scholarly journals Microbial Disease Spectrum Linked to a Novel IL-12Rβ1 N-Terminal Signal Peptide Stop-Gain Homozygous Mutation with Paradoxical Receptor Cell-Surface Expression

2017 ◽  
Vol 8 ◽  
Author(s):  
Thais Louvain de Souza ◽  
Regina C. de Souza Campos Fernandes ◽  
Juliana Azevedo da Silva ◽  
Vladimir Gomes Alves Júnior ◽  
Adelia Gomes Coelho ◽  
...  
Keyword(s):  
Cell Surface ◽  
Signal Peptide ◽  
Receptor Cell ◽  
Surface Expression ◽  
Cell Surface Expression ◽  
Homozygous Mutation ◽  
Disease Spectrum ◽  
Microbial Disease

scholarly journals P2X7 Receptor Cell Surface Expression and Cytolytic Pore Formation Are Regulated by a Distal C-terminal Region

2002 ◽  
Vol 278 (10) ◽  
pp. 8853-8860 ◽  
Author(s):  
Megan L. Smart ◽  
Ben Gu ◽  
Rekha G. Panchal ◽  
James Wiley ◽  
Brett Cromer ◽  
...  
Keyword(s):  
Cell Surface ◽  
P2x7 Receptor ◽  
Pore Formation ◽  
Receptor Cell ◽  
Surface Expression ◽  
Terminal Region ◽  
Cell Surface Expression

scholarly journals Engaged urokinase receptors enhance tumor breast cell migration and invasion by upregulating ?v?5 vitronectin receptor cell surface expression

2002 ◽  
Vol 102 (6) ◽  
pp. 562-571 ◽  
Author(s):  
Immacolata Silvestri ◽  
Immacolata Longanesi Cattani ◽  
Paola Franco ◽  
Giuseppe Pirozzi ◽  
Gerardo Botti ◽  
...  
Keyword(s):  
Cell Migration ◽  
Cell Surface ◽  
Receptor Cell ◽  
Surface Expression ◽  
Cell Surface Expression ◽  
Migration And Invasion ◽  
Vitronectin Receptor ◽  
Cell Migration And Invasion
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