Do vascular risk factors play a role in the progression of mild cognitive impairment?

2009 ◽  
Vol 283 (1-2) ◽  
pp. 261
Author(s):  
B. Vicini Chilovi ◽  
M. Conti ◽  
I. Del Rio ◽  
M. Zanetti ◽  
M. Peli ◽  
...  
Keyword(s):  
Risk Factors ◽  
Cognitive Impairment ◽  
Mild Cognitive Impairment ◽  
Vascular Risk Factors ◽  
Vascular Risk

scholarly journals Mild cognitive impairment: Incidence and vascular risk factors in a population-based cohort

Neurology ◽  
2013 ◽  
Vol 80 (23) ◽  
pp. 2112-2120 ◽  
Author(s):  
M. Ganguli ◽  
B. Fu ◽  
B. E. Snitz ◽  
T. F. Hughes ◽  
C.-C. H. Chang
Keyword(s):  
Risk Factors ◽  
Cognitive Impairment ◽  
Mild Cognitive Impairment ◽  
Population Based ◽  
Vascular Risk Factors ◽  
Vascular Risk

scholarly journals Aggregation of Vascular Risk Factors Modulates the Amplitude of Low-Frequency Fluctuation in Mild Cognitive Impairment Patients

2020 ◽  
Vol 12 ◽  
Author(s):  
Liying Zhuang ◽  
Huafu Ni ◽  
Junyang Wang ◽  
Xiaoyan Liu ◽  
Yajie Lin ◽  
...  
Keyword(s):  
Risk Factors ◽  
Cognitive Impairment ◽  
Mild Cognitive Impairment ◽  
Brain Activity ◽  
Low Frequency ◽  
Vascular Risk Factors ◽  
Vascular Risk ◽  
Cvd Risk ◽  
Spontaneous Brain Activity ◽  
Main Effect

Background: Several vascular risk factors, including hypertension, diabetes, body mass index, and smoking status are found to be associated with cognitive decline and the risk of Alzheimer's disease (AD). We aimed to investigate whether an aggregation of vascular risk factors modulates the amplitude of low-frequency fluctuation (ALFF) in patients with mild cognitive impairment (MCI).Methods: Forty-three MCI patients and twenty-nine healthy controls (HCs) underwent resting-state functional MRI scans, and spontaneous brain activity was measured by the ALFF technique. The vascular risk profile was represented with the Framingham Heart Study general cardiovascular disease (FHS-CVD) risk score, and each group was further divided into high and low risk subgroups. Two-way ANOVA was performed to explore the main effects of diagnosis and vascular risk and their interaction on ALFF.Results: The main effect of diagnosis on ALFF was found in left middle temporal gyrus (LMTG) and left superior parietal gyrus (LSPG), and the main effect of risk on ALFF was detected in left fusiform gyrus (LFFG), left precuneus (LPCUN), and left cerebellum posterior lobe (LCPL). Patients with MCI exhibited increased ALFF in the LMTG and LSPG than HCs, and participants with high vascular risk showed increased ALFF in the LFFG and LCPL, while decreased ALFF in the LPCUN. An interaction between diagnosis (MCI vs. HC) and FHS-CVD risk (high vs. low) regarding ALFF was observed in the left hippocampus (LHIP). HCs with high vascular risk showed significantly increased ALFF in the LHIP than those with low vascular risk, while MCI patients with high vascular risk showed decreased ALFF in the LHIP than HCs with high vascular risk. Interestingly, the mean ALFF of LHIP positively correlated with word recall test in HCs with high vascular risk (rho = 0.630, P = 0.016), while negatively correlated with the same test in MCI patients with high vascular risk (rho = −0.607, P = 0.001).Conclusions: This study provides preliminary evidence highlighting that the aggregation of vascular risk factors modulates the spontaneous brain activity in MCI patients, and this may serve as a potential imaging mechanism underlying vascular contribution to AD.

scholarly journals Fibrinogen Levels and Cognitive Profile Differences in Patients with Mild Cognitive Impairment

2020 ◽  
pp. 1-8
Author(s):  
Jung-Min Pyun ◽  
Nayoung Ryoo ◽  
Young Ho Park ◽  
SangYun Kim
Keyword(s):  
Risk Factors ◽  
Cognitive Impairment ◽  
Executive Function ◽  
Mild Cognitive Impairment ◽  
Disease Progression ◽  
Vascular Risk Factors ◽  
Plasma Fibrinogen ◽  
Cognitive Test ◽  
Vascular Risk ◽  
Confrontation Naming

<b><i>Background:</i></b> Fibrinogen is considered a marker of vascular pathology, indicating a weakened blood-brain barrier, and has a causative role in neuroinflammation and neurodegeneration. Little is known about the relationship between fibrinogen levels and cognitive function in patients with mild cognitive impairment (MCI). We aimed to investigate differences in cognitive profiles according to plasma fibrinogen levels in patients with MCI and the influence of plasma fibrinogen levels on cognitive decline. <b><i>Methods:</i></b> This retrospective cohort study included 643 patients with MCI: 323 patients in the high fibrinogen (high fib) group and 320 patients in the low fibrinogen (low fib) group. A multiple linear regression model was performed to compare cognitive test performance between groups. The Cox proportional hazard model was used to analyze the hazard ratio of fibrinogen level for disease progression. <b><i>Results:</i></b> The high fib group demonstrated poorer performance in attention, executive function, and confrontation naming than the low fib group. After adjustment for <i>APOE</i> genotype, the high fib group was associated with poor attention and executive function. After adjustment for vascular risk factors including body mass index, hypertension, diabetes mellitus, dyslipidemia, and smoking history, the high fib group showed declined attention and confrontation naming ability. High fibrinogen levels did not predict disease progression to CDR 1. <b><i>Conclusion:</i></b> High plasma fibrinogen levels were associated with poor performance in attention in patients with MCI, regardless of <i>APOE</i> genotype or vascular risk factors.

scholarly journals Impact of Vascular Risk Factors and Diseases on Cognition in Persons with Mild Cognitive Impairment

2009 ◽  
Vol 27 (4) ◽  
pp. 375-381 ◽  
Author(s):  
Sylvia Villeneuve ◽  
Sylvie Belleville ◽  
Fadi Massoud ◽  
Christian Bocti ◽  
Serge Gauthier
Keyword(s):  
Risk Factors ◽  
Cognitive Impairment ◽  
Mild Cognitive Impairment ◽  
Vascular Risk Factors ◽  
Vascular Risk
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