Cathepsin K Inhibitor Regulates Inflammation and Bone Destruction in Experimentally Induced Rat Periapical Lesions

Journal of Endodontics ◽

10.1016/j.joen.2015.04.013 ◽

2015 ◽

Vol 41 (9) ◽

pp. 1474-1479 ◽

Author(s):

Noriyuki Suzuki ◽

Koyo Takimoto ◽

Nobuyuki Kawashima

Keyword(s):

Bone Destruction ◽

Cathepsin K ◽

Periapical Lesions ◽

Cathepsin K Inhibitor ◽

Experimentally Induced

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ST2 Deletion Increases Inflammatory Bone Destruction in Experimentally Induced Periapical Lesions in Mice

Journal of Endodontics ◽

10.1016/j.joen.2014.11.017 ◽

2015 ◽

Vol 41 (3) ◽

pp. 369-375 ◽

Author(s):

Milena Velickovic ◽

Nada Pejnovic ◽

Slobodanka Mitrovic ◽

Gordana Radosavljevic ◽

Ivan Jovanovic ◽

...

Keyword(s):

Bone Destruction ◽

Periapical Lesions ◽

Experimentally Induced

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Faculty Opinions recommendation of Cathepsin K deficiency partially inhibits, but does not prevent, bone destruction in human tumor necrosis factor-transgenic mice.

Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature ◽

10.3410/f.1103232.565151 ◽

2008 ◽

Author(s):

Thomas Pap ◽

Marvin Peters ◽

Berno Dankbar

Keyword(s):

Tumor Necrosis Factor ◽

Transgenic Mice ◽

Tumor Necrosis ◽

Human Tumor ◽

Bone Destruction ◽

Cathepsin K ◽

Human Tumor Necrosis Factor ◽

K Deficiency ◽

Necrosis Factor

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Faculty Opinions recommendation of Disease-Modifying Effects of a Novel Cathepsin K Inhibitor in Osteoarthritis: A Randomized, Placebo-Controlled Study.

Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature ◽

10.3410/f.737143597.793573698 ◽

2020 ◽

Author(s):

Susanne Grässel

Keyword(s):

Cathepsin K ◽

Controlled Study ◽

Cathepsin K Inhibitor ◽

Disease Modifying

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112 EFFECT OF THE SELECTIVE CATHEPSIN K INHIBITOR, MIV-711, ON MARKERS OF CARTILAGE DEGRADATION AND ON GROSS AND HISTOPATHOLOGY SCORES IN DOGS SUBJECTED TO PARTIAL MEDIAL MENISCECTOMY, AN EXPERIMENTAL MODEL OF OSTEOARTHRITIS

Osteoarthritis and Cartilage ◽

10.1016/s1063-4584(11)60139-8 ◽

2011 ◽

Vol 19 ◽

pp. S59

Author(s):

E. Lindstrom ◽

L. Vrang ◽

S. Sedig ◽

Y. Terelius ◽

K. Wikström ◽

...

Keyword(s):

Experimental Model ◽

Cathepsin K ◽

Cartilage Degradation ◽

Cathepsin K Inhibitor ◽

Medial Meniscectomy

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Effect of the selective cathepsin K inhibitor MIV-711 on bone resorption and cartilage degradation biomarkers and on knee joint pathology in dogs subjected to partial medial meniscectomy, an experimental model of osteoarthritis

Bone ◽

10.1016/j.bone.2012.02.598 ◽

2012 ◽

Vol 50 ◽

pp. S188-S189 ◽

Author(s):

E. Lindstrom⁎ ◽

L. Vrang ◽

S. Sedig ◽

Y. Terelius ◽

K. Wikström ◽

...

Keyword(s):

Bone Resorption ◽

Experimental Model ◽

Cathepsin K ◽

Cartilage Degradation ◽

Cathepsin K Inhibitor ◽

Joint Pathology ◽

Medial Meniscectomy ◽

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Modeling and simulation of bone mineral density response from a phase 2 study of ONO-5334, a new cathepsin K inhibitor, to support dose selection in osteoporosis

The Journal of Clinical Pharmacology ◽

10.1002/jcph.279 ◽

2014 ◽

Vol 54 (8) ◽

pp. 937-948 ◽

Author(s):

Chihiro Hasegawa ◽

Helen Kastrissios ◽

Jonathan Monteleone ◽

Tomoya Ohno ◽

Takeo Umemura ◽

...

Keyword(s):

Bone Mineral Density ◽

Modeling And Simulation ◽

Bone Mineral ◽

Cathepsin K ◽

Phase 2 ◽

Mineral Density ◽

Dose Selection ◽

Cathepsin K Inhibitor ◽

Phase 2 Study ◽

Density Response

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Letter: The Effects of Combination Therapy of Cathepsin K Inhibitor and PTH on Change in Bone Mineral Density in an Animal Model of Osteoporosis

Endocrinology and Metabolism ◽

10.3803/enm.2012.27.1.105 ◽

2012 ◽

Vol 27 (1) ◽

pp. 105

Author(s):

Sang Ah Lee

Keyword(s):

Bone Mineral Density ◽

Animal Model ◽

Combination Therapy ◽

Bone Mineral ◽

Cathepsin K ◽

Mineral Density ◽

Cathepsin K Inhibitor

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Protective effects of a cathepsin K inhibitor, SB-553484, in the canine partial medial meniscectomy model of osteoarthritis

Osteoarthritis and Cartilage ◽

10.1016/j.joca.2009.03.015 ◽

2009 ◽

Vol 17 (9) ◽

pp. 1236-1243 ◽

Author(s):

J.R. Connor ◽

C. LePage ◽

B.A. Swift ◽

D. Yamashita ◽

A.M. Bendele ◽

...

Keyword(s):

Cathepsin K ◽

Protective Effects ◽

Cathepsin K Inhibitor ◽

Medial Meniscectomy

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The selective cathepsin K inhibitor MIV-711 attenuates joint pathology in experimental animal models of osteoarthritis

Journal of Translational Medicine ◽

10.1186/s12967-018-1425-7 ◽

2018 ◽

Vol 16 (1) ◽

Author(s):

Erik Lindström ◽

Biljana Rizoska ◽

Karin Tunblad ◽

Charlotte Edenius ◽

Alison M. Bendele ◽

...

Keyword(s):

Animal Models ◽

Experimental Animal ◽

Cathepsin K ◽

Experimental Animal Models ◽

Cathepsin K Inhibitor ◽

Joint Pathology

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Morning vs evening dosing of the cathepsin K inhibitor ONO-5334: effects on bone resorption in postmenopausal women in a randomized, phase 1 trial

Osteoporosis International ◽

10.1007/s00198-015-3342-4 ◽

2015 ◽

Vol 27 (1) ◽

pp. 309-318 ◽

Author(s):

R. Eastell ◽

D.-J. Dijk ◽

M. Small ◽

A. Greenwood ◽

J. Sharpe ◽

...

Keyword(s):

Bone Resorption ◽

Postmenopausal Women ◽

Phase 1 ◽

Cathepsin K ◽

Phase 1 Trial ◽

Cathepsin K Inhibitor

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