Psychosocial strain and therapeutic approaches of hereditary neurological diseases: A systematic review

2013 ◽  
Vol 74 (6) ◽  
pp. 560
Author(s):  
F. Vitinius ◽  
C. Imlau ◽  
C. Albus
Keyword(s):  
Systematic Review ◽  
Neurological Diseases ◽  
Therapeutic Approaches ◽  
Hereditary Neurological Diseases

scholarly journals Vibrotactile-Based Rehabilitation on Balance and Gait in Patients with Neurological Diseases: A Systematic Review and Metanalysis

2021 ◽  
Vol 11 (4) ◽  
pp. 518
Author(s):  
Sara De Angelis ◽  
Alessandro Antonio Princi ◽  
Fulvio Dal Farra ◽  
Giovanni Morone ◽  
Carlo Caltagirone ◽  
...  
Keyword(s):  
Systematic Review ◽  
Fear Of Falling ◽  
Neurological Diseases ◽  
Cerebrovascular Diseases ◽  
Gait Rehabilitation ◽  
Proprioceptive Information ◽  
High Quality ◽  
Active Involvement ◽  
Task Oriented ◽  
Multisensory Information

Postural instability and fear of falling represent two major causes of decreased mobility and quality of life in cerebrovascular and neurologic diseases. In recent years, rehabilitation strategies were carried out considering a combined sensorimotor intervention and an active involvement of the patients during the rehabilitation sessions. Accordingly, new technological devices and paradigms have been developed to increase the effectiveness of rehabilitation by integrating multisensory information and augmented feedback promoting the involvement of the cognitive paradigm in neurorehabilitation. In this context, the vibrotactile feedback (VF) could represent a peripheral therapeutic input, in order to provide spatial proprioceptive information to guide the patient during task-oriented exercises. The present systematic review and metanalysis aimed to explore the effectiveness of the VF on balance and gait rehabilitation in patients with neurological and cerebrovascular diseases. A total of 18 studies met the inclusion criteria and were included. Due to the lack of high-quality studies and heterogeneity of treatments protocols, clinical practice recommendations on the efficacy of VF cannot be made. Results show that VF-based intervention could be a safe complementary sensory-motor approach for balance and gait rehabilitation in patients with neurological and cerebrovascular diseases. More high-quality randomized controlled trials are needed.

scholarly journals Internal jugular phlebectasia: A systematic review

2019 ◽  
Vol 10 ◽  
pp. 106 ◽  
Author(s):  
Jose A. Figueroa-Sanchez ◽  
Ana S. Ferrigno ◽  
Mario Benvenutti-Regato ◽  
Enrique Caro-Osorio ◽  
Hector R. Martinez
Keyword(s):  
Systematic Review ◽  
Natural History ◽  
Conservative Treatment ◽  
Literature Search ◽  
Jugular Vein ◽  
Adult Patients ◽  
Therapeutic Approaches ◽  
Jugular Phlebectasia ◽  
The Right ◽  
Meta Analyses

Background: Internal jugular phlebectasia (IJP), the abnormal dilatation of internal jugular vein, is generally considered a benign anomaly. However, because IJP is uncommon, little is known about its natural history, and currently, no consensus on the best treatment modality is available. Methods: The purpose of this article is to conduct a systematic review of available literature on recently reported IJP cases to understand the main characteristics of IJP and its most frequent therapeutic approaches. Following the preferred reporting items for systematic reviews and meta-analyses guidelines, literature search for IJP cases was conducted in the COCHRANE, PUBMED, EBSCOHOST, SCOPUS, OVID, and SCIELO databases. Results: A total of 97 original articles were found, with a total of 247 IJP cases reported including both pediatric and adult patients. Conclusions: To the best of our knowledge, this study is the largest systematic review analyzing all the reported cases of IJP. IJP is considered by most authors as a benign abnormality that predominantly affects the right jugular vein. It is most commonly diagnosed in children. At present, conservative treatment is preferred for pediatric but not for adult patients. Multicenter randomized prospective studies are required to further understand this rare anomaly.

scholarly journals Pancreatitis Associated with Viral Hepatitis: Systematic Review

2020 ◽  
Vol 9 (10) ◽  
pp. 3309
Author(s):  
Nikola Panic ◽  
Sladjana Mihajlovic ◽  
Miroslav Vujasinovic ◽  
Milutin Bulajic ◽  
Johannes-Matthias Löhr
Keyword(s):  
Systematic Review ◽  
Viral Hepatitis ◽  
Hepatitis A Virus ◽  
Hepatitis Virus ◽  
Hepatitis E ◽  
Therapeutic Approaches ◽  
Substantial Impact ◽  
Pancreatic Involvement ◽  
B Virus ◽  
Reporting Data

Background: We conducted a systematic review in order to summarize the available data on pancreatitis associated with viral hepatitis. Methods: A comprehensive literature search of Medline, Scopus and ISI Web of Science databases was conducted and papers eligible for the inclusion identified. Results: In total, 46 studies reporting data on 73 patients were included in the analysis. Most of the cases were diagnosed in Asia (57.53%), followed by North America (23.29%), and Europe (13.70%). Most of the patients were affected by hepatitis A virus (HAV) (42.47%), followed by hepatitis E virus (HEV) (28.77%), hepatitis B virus (HBV) (8.22%), and hepatitis C virus (HCV) (1.37%), while 17.81% at the time of diagnosis were classified as affected by “hepatitis virus”. Pancreatitis was severe in 32.88% of cases. The respiratory system was affected in 2.74% of patients, 6.85% experienced renal failure, while 5.48% experienced a multiorgan dysfunction syndrome (MODS). Four patients (5.48%) needed pancreatic surgery. Despite the treatment, 21.92% of patients died. We identified fulminant hepatitis (p < 0.0001), MODS (p < 0.0001) and severe pancreatitis (p < 0.0001) to be significantly more present in patients who died in comparison to cured ones. Conclusion: Increased awareness of pancreatic involvement in viral hepatitis is needed because it can have a substantial impact on therapeutic approaches and outcomes.

scholarly journals Therapeutic Approaches for Volumetric Muscle Loss Injury: A Systematic Review and Meta-Analysis

2019 ◽  
Vol 25 (6) ◽  
pp. 510-525 ◽  
Author(s):  
Sarah M. Greising ◽  
Benjamin T. Corona ◽  
Christopher McGann ◽  
Jeremy K. Frankum ◽  
Gordon L. Warren
Keyword(s):  
Systematic Review ◽  
Meta Analysis ◽  
Muscle Loss ◽  
Therapeutic Approaches ◽  
Volumetric Muscle Loss

scholarly journals Oxidative Stress and the Microbiota-Gut-Brain Axis

2018 ◽  
Vol 2018 ◽  
pp. 1-12 ◽  
Author(s):  
Laura Dumitrescu ◽  
Iulia Popescu-Olaru ◽  
Liviu Cozma ◽  
Delia Tulbă ◽  
Mihail Eugen Hinescu ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Neurological Diseases ◽  
Brain Lesions ◽  
Brain Inflammation ◽  
Oxygen Species ◽  
Mutual Relationship ◽  
Therapeutic Approaches ◽  
Physiological Regulation ◽  
New Therapeutic Approaches ◽  
Important Pathway

The gut-brain axis is increasingly recognized as an important pathway of communication and of physiological regulation, and gut microbiota seems to play a significant role in this mutual relationship. Oxidative stress is one of the most important pathogenic mechanisms for both neurodegenerative diseases, such as Alzheimer’s or Parkinson’s, and acute conditions, such as stroke or traumatic brain injury. A peculiar microbiota type might increase brain inflammation and reactive oxygen species levels and might favor abnormal aggregation of proteins. Reversely, brain lesions of various etiologies result in alteration of gut properties and microbiota. These recent hypotheses could open a door for new therapeutic approaches in various neurological diseases.

scholarly journals Adipose-Derived Mesenchymal Stem Cells for the Treatment of Articular Cartilage: A Systematic Review on Preclinical and Clinical Evidence

2015 ◽  
Vol 2015 ◽  
pp. 1-13 ◽  
Author(s):  
Francesco Perdisa ◽  
Natalia Gostyńska ◽  
Alice Roffi ◽  
Giuseppe Filardo ◽  
Maurilio Marcacci ◽  
...  
Keyword(s):  
Systematic Review ◽  
Stem Cells ◽  
Mesenchymal Stem Cells ◽  
Articular Cartilage ◽  
Clinical Evidence ◽  
Cartilage Regeneration ◽  
Therapeutic Approaches ◽  
Differentiated Cells ◽  
Cartilage Disease

Among the current therapeutic approaches for the regeneration of damaged articular cartilage, none has yet proven to offer results comparable to those of native hyaline cartilage. Recently, it has been claimed that the use of mesenchymal stem cells (MSCs) provides greater regenerative potential than differentiated cells, such as chondrocytes. Among the different kinds of MSCs available, adipose-derived mesenchymal stem cells (ADSCs) are emerging due to their abundancy and easiness to harvest. However, their mechanism of action and potential for cartilage regeneration are still under investigation, and many other aspects still need to be clarified. The aim of this systematic review is to give an overview ofin vivostudies dealing with ADSCs, by summarizing the main evidence for the treatment of cartilage disease of the knee.

scholarly journals Essential Role for Sphingosine Kinases in Neural and Vascular Development

2005 ◽  
Vol 25 (24) ◽  
pp. 11113-11121 ◽  
Author(s):  
Kiyomi Mizugishi ◽  
Tadashi Yamashita ◽  
Ana Olivera ◽  
Georgina F. Miller ◽  
Sarah Spiegel ◽  
...  
Keyword(s):  
Neurological Diseases ◽  
Vascular Development ◽  
Neural Tube Closure ◽  
Vascular Endothelial ◽  
Therapeutic Approaches ◽  
Cellular Processes ◽  
Survival Pathway ◽  
Sphingosine 1 Phosphate ◽  
Sphingosine Kinases ◽  
Endothelial Growth Factor

ABSTRACT Sphingosine-1-phosphate (S1P), an important sphingolipid metabolite, regulates diverse cellular processes, including cell survival, growth, and differentiation. Here we show that S1P signaling is critical for neural and vascular development. Sphingosine kinase-null mice exhibited a deficiency of S1P which severely disturbed neurogenesis, including neural tube closure, and angiogenesis and caused embryonic lethality. A dramatic increase in apoptosis and a decrease in mitosis were seen in the developing nervous system. S1P1 receptor-null mice also showed severe defects in neurogenesis, indicating that the mechanism by which S1P promotes neurogenesis is, in part, signaling from the S1P1 receptor. Thus, S1P joins a growing list of signaling molecules, such as vascular endothelial growth factor, which regulate the functionally intertwined pathways of angiogenesis and neurogenesis. Our findings also suggest that exploitation of this potent neuronal survival pathway could lead to the development of novel therapeutic approaches for neurological diseases.

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