scholarly journals Anti-rheumatoid activity of ethanolic extract of Sesamum indicum seed extract in Freund's complete adjuvant induced arthritis in Wistar albino rats

2018 ◽  
Vol 8 (3) ◽  
pp. 377-386 ◽  
Author(s):  
A. Ruckmani ◽  
Vinayak Meti ◽  
R. Vijayashree ◽  
R. Arunkumar ◽  
Venugopala Rao Konda ◽  
...  
Keyword(s):  
Ethanolic Extract ◽  
Sesamum Indicum ◽  
Seed Extract ◽  
Albino Rats ◽  
Freund’S Complete Adjuvant ◽  
Adjuvant Induced Arthritis ◽  
Freund's Complete Adjuvant ◽  
Wistar Albino Rats

Anti-Rheumatoid activity of Sesamin Complex in Freund's Complete Adjuvant induced arthritis in Wistar albino rats

2021 ◽  
Vol 23 (23) ◽  
Author(s):  
Tanuja Lella ◽  
A. Ruckmani ◽  
R. Arunkumar ◽  
R. Vijayashree ◽  
E. Abinaya ◽  
...  
Keyword(s):  
Albino Rats ◽  
Freund’S Complete Adjuvant ◽  
Adjuvant Induced Arthritis ◽  
Freund's Complete Adjuvant ◽  
Wistar Albino Rats

scholarly journals Evaluation of Prophylactic Diacerein Treatment on Anti-Arthritic Activity in Freund’s Complete Adjuvant-Induced Arthritis in Rat Model

2021 ◽  
Author(s):  
Rajlaxmi Upadhyay ◽  
Trupti Rekha Swain ◽  
Sabita Mohapatra ◽  
Manas Ranjan Upadhyay
Keyword(s):  
Body Weight ◽  
Normal Saline ◽  
Clinical Symptoms ◽  
Symptomatic Treatment ◽  
Albino Rats ◽  
Freund’S Complete Adjuvant ◽  
Adjuvant Induced Arthritis ◽  
Freund's Complete Adjuvant ◽  
Freund’S Adjuvant ◽  
Freund's Adjuvant

Introduction: Osteoarthritis (OA) is commonly prevalent disorder seen in Indian population. Nonsteroidal Anti-Inflammatory Drugs (NSAIDS) are used as primary drugs for its symptomatic treatment. However, its use is limited by its long-term adverse effects. Many clinical studies have shown that diacerein reduces clinical symptoms of OA. Aim: To evaluate whether diacerein has beneficial anti-arthritic property when used prophylactically in Freund’s Complete Adjuvant (FCA) induced arthritis in rats. Materials and Methods: An experimental study was conducted over a period of about two months in the Department of Pharmacology, SCBMC, Cuttack. Thirty albino rats of Wistar strain was divided into 5 groups with 6 animals in each group. The basal body weight and the hind paw volumes of both right and left paw of all the animals was noted in day 0 and then on 4th, 8th, 14th and 21st day. Arthritis was induced in all animals by injecting FCA on day 0 into the plantar surface of right hind paw. Normal saline, diclofenac 5 mg/kg, three doses of diacerein (50 mg/kg, 100 mg/kg, 200 mg/kg), was administered orally once daily to groups I, II, III, IV and V respectively. Paw volumes and body weight was measured for arthritic parameters. On day 22 radiological and histopathologic evaluation was done. Results: Maximum inhibition of Freund’s adjuvant induced arthritic paw volume was on the 21st day with 100 mg/kg of diacerein and with diclofenac 5 mg/kg was from 8th to 14th day. There was a decrease in body weight due to freund’s adjuvant in normal saline group from 4th to 21st day, still greater decline with diclofenac 5 mg/kg group, but in diacerein treated group there was an increase in body weight from 4th to 21st day in all the three doses. Radiologically and histopathology maximum benefit was noted with 100 mg/kg of diacerein. Conclusion: Three weeks treatment of oral diacerein can significantly inhibit arthritic swelling of the injected paw at all the 3 doses in adjuvant induced arthritis model in rats and can be a promising disease modifying drug for OA.

scholarly journals Protective Effect of Ethanolic Extract ofTabernaemontana divaricata(L.) R. Br. against DEN and Fe NTA Induced Liver Necrosis in Wistar Albino Rats

2014 ◽  
Vol 2014 ◽  
pp. 1-9 ◽  
Author(s):  
Kannappan Poornima ◽  
Palanisamy Chella Perumal ◽  
Velliyur Kanniappan Gopalakrishnan
Keyword(s):  
Ethanolic Extract ◽  
Treated Group ◽  
Hepatic Necrosis ◽  
Hepatoprotective Activity ◽  
Albino Rats ◽  
Protective Effects ◽  
Liver Necrosis ◽  
Standard Drug ◽  
Tabernaemontana Divaricata ◽  
Wistar Albino Rats

This study is an attempt to evaluate the hepatoprotective activity ofTabernaemontana divaricataagainst DEN and Fe NTA induced liver necrosis in rats. Ethanolic extract of the whole plant ofTabernaemontana divaricataat doses of 200 and 400 mg/kg body weight and 5-fluorouracil (standard drug) was orally administered to male Wistar Albino rats once daily for 24 weeks, simultaneously treated with the carcinogen DEN and Fe NTA. In simultaneously treated animals, the plant extract significantly decreased the levels of uric acid, bilirubin, AST, ALT, and ALP in serum and increased the levels of liver marker enzymes in liver. Treatment with the extracts resulted in a significant increase in the levels of antioxidants accompanied by a marked reduction in the levels of malondialdehyde when compared to DEN and Fe NTA treated group. When compared with 200 mg/kg bw rats, 400 mg/kg bw rats and 5-fluorouracil treated rats showed better results in all the parameters. The histopathological studies confirmed the protective effects of extract against DEN and Fe NTA induced liver necrosis. Thus, it could be concluded that the use ofTabernaemontana divaricataextract in the treatment of carcinogen induced hepatic necrosis.

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