Anti- inflammatory and Anti- Arthritic Activity of Nanocurcumin in Albino Rats against Freund's Complete Adjuvant Induced- Arthritis

2020 ◽  
Vol 11 (05) ◽  
Keyword(s):  
Albino Rats ◽  
Freund’S Complete Adjuvant ◽  
Adjuvant Induced Arthritis ◽  
Freund's Complete Adjuvant ◽  
Anti Inflammatory

Anti-Rheumatoid activity of Sesamin Complex in Freund's Complete Adjuvant induced arthritis in Wistar albino rats

2021 ◽  
Vol 23 (23) ◽  
Author(s):  
Tanuja Lella ◽  
A. Ruckmani ◽  
R. Arunkumar ◽  
R. Vijayashree ◽  
E. Abinaya ◽  
...  
Keyword(s):  
Albino Rats ◽  
Freund’S Complete Adjuvant ◽  
Adjuvant Induced Arthritis ◽  
Freund's Complete Adjuvant ◽  
Wistar Albino Rats

scholarly journals Anti-inflammatory properties of natural ingredients used in combinations on adjuvant induced arthritis in rats

2018 ◽  
Author(s):  
Amélie St-Pierre ◽  
Véronique Desrosiers ◽  
France Dufresne ◽  
Pierre U. Blier
Keyword(s):  
Rheumatoid Arthritis ◽  
Antioxidant Activity ◽  
Total Antioxidant Activity ◽  
Salix Alba ◽  
Boswellia Serrata ◽  
Freund’S Complete Adjuvant ◽  
Adjuvant Induced Arthritis ◽  
Freund's Complete Adjuvant ◽  
Total Antioxidant ◽  
Anti Inflammatory

AbstractBackground: Rheumatoid arthritis has seen a significant increase in both incidence and prevalence and its treatments show limited efficiency due to their undesirable effects on patient health. Therefore, major interests lie in the development of treatments with drugs derived from plants or other natural sources with little adverse effects as an alternative to current treatments.Hypothesis/Purpose: The present study evaluates the therapeutic effects of glucosamine against rheumatoid arthritis in combination with hyaluronic acid, resin extract of Boswellia serrata or a bark extract of Salix alba on an animal model. We suggest that combinations with plants could improve the attenuation of arthritis symptoms and articular inflammation.Study design: We used Freund’s complete adjuvant on rats as models of rheumatoid arthritis. Individuals were separated into eight experimental groups: a control group without arthritis, one with arthritis and without treatment, and six other groups receiving a daily therapeutic treatment from days 14 to 29.Methods: Hind-paw thickness and arthritis scores were measured at days 0, 3, 6 and 9 post-induction, and then every day from days 12 to 29 with a digital caliper and a score system respectively. At the end of the treatment, the mRNA content of three pro-inflammatory cytokines from cartilage was measured using real-time PCR. The total antioxidant activity was evaluated with an Antioxidant Assay Kit.Results: Treatments with Boswellia serrata and Salix alba (Glu+Hyal A+Bosw, Glu+Bosw+Sal, Glu+Bosw and Glu+Hyal A+Sal) saw significant reductions in hind-paw thickness and arthritis scores at the end of the experiment when compared to the untreated group. Expression of pro-inflammatory gene IL 17A was also reduced, but only the Glu+Hyal A+Sal combination significantly decreased the expression of IL-1β and TNF-α. The total antioxidant activity in blood plasma significantly increased in groups treated with plant extracts.Conclusion: The addition of Boswellia serrata and/or Salix alba attenuates clinical signs of rheumatoid arthritis in Freund’s complete adjuvant-induced arthritis in rats likely due to both their anti-inflammatory and antioxidant properties.

scholarly journals Evaluation of Prophylactic Diacerein Treatment on Anti-Arthritic Activity in Freund’s Complete Adjuvant-Induced Arthritis in Rat Model

2021 ◽  
Author(s):  
Rajlaxmi Upadhyay ◽  
Trupti Rekha Swain ◽  
Sabita Mohapatra ◽  
Manas Ranjan Upadhyay
Keyword(s):  
Body Weight ◽  
Normal Saline ◽  
Clinical Symptoms ◽  
Symptomatic Treatment ◽  
Albino Rats ◽  
Freund’S Complete Adjuvant ◽  
Adjuvant Induced Arthritis ◽  
Freund's Complete Adjuvant ◽  
Freund’S Adjuvant ◽  
Freund's Adjuvant

Introduction: Osteoarthritis (OA) is commonly prevalent disorder seen in Indian population. Nonsteroidal Anti-Inflammatory Drugs (NSAIDS) are used as primary drugs for its symptomatic treatment. However, its use is limited by its long-term adverse effects. Many clinical studies have shown that diacerein reduces clinical symptoms of OA. Aim: To evaluate whether diacerein has beneficial anti-arthritic property when used prophylactically in Freund’s Complete Adjuvant (FCA) induced arthritis in rats. Materials and Methods: An experimental study was conducted over a period of about two months in the Department of Pharmacology, SCBMC, Cuttack. Thirty albino rats of Wistar strain was divided into 5 groups with 6 animals in each group. The basal body weight and the hind paw volumes of both right and left paw of all the animals was noted in day 0 and then on 4th, 8th, 14th and 21st day. Arthritis was induced in all animals by injecting FCA on day 0 into the plantar surface of right hind paw. Normal saline, diclofenac 5 mg/kg, three doses of diacerein (50 mg/kg, 100 mg/kg, 200 mg/kg), was administered orally once daily to groups I, II, III, IV and V respectively. Paw volumes and body weight was measured for arthritic parameters. On day 22 radiological and histopathologic evaluation was done. Results: Maximum inhibition of Freund’s adjuvant induced arthritic paw volume was on the 21st day with 100 mg/kg of diacerein and with diclofenac 5 mg/kg was from 8th to 14th day. There was a decrease in body weight due to freund’s adjuvant in normal saline group from 4th to 21st day, still greater decline with diclofenac 5 mg/kg group, but in diacerein treated group there was an increase in body weight from 4th to 21st day in all the three doses. Radiologically and histopathology maximum benefit was noted with 100 mg/kg of diacerein. Conclusion: Three weeks treatment of oral diacerein can significantly inhibit arthritic swelling of the injected paw at all the 3 doses in adjuvant induced arthritis model in rats and can be a promising disease modifying drug for OA.

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