Bipartite mechanism for laminin-integrin interactions: Identification of the integrin-binding site in LG domains of the laminin α chain

2020 ◽  
Vol 87 ◽  
pp. 66-76 ◽  
Author(s):  
Yukimasa Taniguchi ◽  
Mamoru Takizawa ◽  
Shaoliang Li ◽  
Kiyotoshi Sekiguchi
Keyword(s):  
Binding Site ◽  
Integrin Binding Site ◽  
Α Chain

scholarly journals Identification of a novel integrin binding site in fibronectin. Differential utilization by beta 3 integrins.

1994 ◽  
Vol 269 (14) ◽  
pp. 10856-10863 ◽  
Author(s):  
R.D. Bowditch ◽  
M. Hariharan ◽  
E.F. Tominna ◽  
J.W. Smith ◽  
K.M. Yamada ◽  
...  
Keyword(s):  
Binding Site ◽  
Integrin Binding Site

scholarly journals Integrin binding site within the gC1q domain orchestrates EMILIN-1-induced lymphangiogenesis

2019 ◽  
Vol 81 ◽  
pp. 34-49 ◽  
Author(s):  
Alessandra Capuano ◽  
Eliana Pivetta ◽  
Francesca Baldissera ◽  
Giulia Bosisio ◽  
Bruna Wassermann ◽  
...  
Keyword(s):  
Binding Site ◽  
Integrin Binding Site

Structure of HIV-1 gp120 V1V2 in Complex with Human mAb 830A Reveals a 5-Stranded Beta Barrel Conformation and Integrin-binding Site

2014 ◽  
Vol 30 (S1) ◽  
pp. A18-A19
Author(s):  
Ruimin Pan ◽  
Miroslaw K. Gorny ◽  
Susan Zolla-Pazner ◽  
Xiang-Peng Kong
Keyword(s):  
Binding Site ◽  
Beta Barrel ◽  
Integrin Binding Site ◽  
Hiv 1

scholarly journals Cross-talk of Integrin α3β1 and Tissue Factor in Cell Migration

2004 ◽  
Vol 15 (10) ◽  
pp. 4416-4425 ◽  
Author(s):  
Andrea Dorfleutner ◽  
Edith Hintermann ◽  
Takehiko Tarui ◽  
Yoshikazu Takada ◽  
Wolfram Ruf
Keyword(s):  
Cell Migration ◽  
Binding Site ◽  
Tissue Factor ◽  
Extracellular Domain ◽  
Cytoplasmic Domain ◽  
Β1 Integrin ◽  
Laminin 5 ◽  
Integrin Binding Site ◽  
Integrin Ligand ◽  
Integrin Α3β1

In cancer and angiogenesis, coagulation-independent roles of tissue factor (TF) in cell migration are incompletely understood. Immobilized anti-TF extracellular domain antibodies induce cell spreading, but this phenomenon is epitope specific and is not induced by anti-TF 5G9. Spreading on anti-TF is β1 integrin–dependent, indicating functional interactions of the TF extracellular domain 5G9 epitope (a presumed integrin-binding site) and integrins. Recombinant TF extracellular domain supports adhesion of cells expressing αvβ3 or certain β1 integrin heterodimers (α3β1, α4β1, α5β1, α6β1, α9β1) and adhesion is blocked by specific anti-integrin antibodies or mutations in the integrin ligand-binding site. Although several studies have linked TF to cell migration, we here demonstrate that TF specifically regulates α3β1-dependent migration on laminin 5. Expression of TF suppresses α3β1-dependent migration, but only when the TF cytoplasmic domain is not phosphorylated. Suppression of migration can be reversed by 5G9, presumably by disrupting integrin interaction, or by the protease ligand VIIa, known to induce PAR-2–dependent phosphorylation of TF. In both cases, release of α3β1 inhibition is prevented by mutation of critical phosphorylation sites in the TF cytoplasmic domain. Thus, TF influences integrin-mediated migration through cooperative intra- and extracellular interactions and phosphorylation regulates TF's function in cell motility.

scholarly journals Identification of the integrin-binding site on coagulation factor VIIa required for proangiogenic PAR2 signaling

Blood ◽  
2018 ◽  
Vol 131 (6) ◽  
pp. 674-685 ◽  
Author(s):  
Andrea S. Rothmeier ◽  
Enbo Liu ◽  
Sagarika Chakrabarty ◽  
Jennifer Disse ◽  
Barbara M. Mueller ◽  
...  
Keyword(s):  
Complex Formation ◽  
Cell Surface ◽  
Binding Site ◽  
Factor Viia ◽  
Coagulation Factor ◽  
Binding Motif ◽  
Integrin Β1 ◽  
Key Points ◽  
Integrin Binding Site ◽  
Recycling Pathway

Key Points The FVIIa integrin-binding motif is required for TF-FVIIa complex formation with integrin β1 and proangiogenic signaling. The arf6 integrin recycling pathway controls TF-FVIIa signaling and cell surface availability for procoagulant activity.

scholarly journals Molecular evolution of α4 integrin binding site to lentiviral envelope proteins in new world primates

2012 ◽  
Vol 12 (7) ◽  
pp. 1501-1507 ◽  
Author(s):  
Mirela Darc ◽  
Carlos G. Schrago ◽  
Esmeralda A. Soares ◽  
Alcides Pissinatti ◽  
Albert N. Menezes ◽  
...  
Keyword(s):  
Molecular Evolution ◽  
Binding Site ◽  
New World ◽  
Envelope Proteins ◽  
New World Primates ◽  
Integrin Binding Site

scholarly journals Crystal structure of vinculin in complex with vinculin binding site 50 (VBS50), the integrin binding site 2 (IBS2) of talin

2012 ◽  
Vol 21 (4) ◽  
pp. 583-588 ◽  
Author(s):  
S. D. Yogesha ◽  
Erumbi S. Rangarajan ◽  
Clemens Vonrhein ◽  
Gerard Bricogne ◽  
Tina Izard
Keyword(s):  
Crystal Structure ◽  
Binding Site ◽  
Integrin Binding Site

scholarly journals Ciliary Neurotrophic Factor, Cardiotrophin-like Cytokine, and Neuropoietin Share a Conserved Binding Site on the Ciliary Neurotrophic Factor Receptor α Chain

2008 ◽  
Vol 283 (44) ◽  
pp. 30341-30350 ◽  
Author(s):  
François Rousseau ◽  
Sylvie Chevalier ◽  
Catherine Guillet ◽  
Elisa Ravon ◽  
Caroline Diveu ◽  
...  
Keyword(s):  
Binding Site ◽  
Neurotrophic Factor ◽  
Ciliary Neurotrophic Factor ◽  
Α Chain ◽  
Ciliary Neurotrophic Factor Receptor

scholarly journals The Integrin Binding Site 2 (IBS2) in the Talin Rod Domain Is Essential for Linking Integrin β Subunits to the Cytoskeleton

2007 ◽  
Vol 282 (23) ◽  
pp. 17280-17288 ◽  
Author(s):  
Michèle Moes ◽  
Sophie Rodius ◽  
Stacey J. Coleman ◽  
Susan J. Monkley ◽  
Erik Goormaghtigh ◽  
...  
Keyword(s):  
Binding Site ◽  
Integrin Binding Site
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