Estimation of trace elemental concentration in Azadirachta indica and Withania somnifera anti-cancer medicinal plants of Telangana using EDXRF technique

2021 ◽  
Author(s):  
S. Jyothsna ◽  
G. Manjula ◽  
P. Chandar Rao ◽  
D. Sammaiah ◽  
A.S. Nageswara Rao
Keyword(s):  
Medicinal Plants ◽  
Azadirachta Indica ◽  
Withania Somnifera ◽  
Elemental Concentration ◽  
Anti Cancer ◽  
Trace Elemental ◽  
Edxrf Technique

A Review on Phytopharmaceutical shaving Concomitant Experimental Anti-Diabetic and Anti-Cancer Effects as Potential Sources for Targeted Therapies Against Insulin Mediated Breast Cancer Cell Invasion and Migration

2020 ◽  
Vol 16 ◽  
Author(s):  
Vibhavana Singh ◽  
Rakesh Reddy ◽  
Antarip Sinha ◽  
Venkatesh Marturi ◽  
Shravani Sripathi Panditharadyula ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Medicinal Plants ◽  
Cancer Cell ◽  
Breast Cancer Cell ◽  
Cell Invasion ◽  
Breast Tumor ◽  
Cancer Cell Invasion ◽  
Invasion And Migration ◽  
Anti Cancer ◽  
And Migration

: Diabetes and breast cancer are pathophysiologically similar and clinically established diseases that co-exist with a wider complex similar molecular signalling and having similar set of risk factors. Insulin plays a pivotal role for invasion and migration of breast cancer cells. Several ethnopharmacological evidences light the concomitant anti-diabetic and anti-cancer activity of medicinal plant and phytochemicals against breast tumor of patients with diabetes. This present article reviewed the findings on medicinal plants and phytochemicals with concomitant anti-diabetic and anti-cancer effects reported in scientific literature to facilitate the development of dual-acting therapies against diabetes and breast cancer. The schematic tabular form of published literatures on medicinal plants (63 plants belongs to 45 families) concluded the dynamics of phytochemicals against diabetes and breast tumor that could be explored further for the discovery of therapies for controlling of breast cancer cell invasion and migration in patient with diabetes.

A review of the mechanisms of anti-cancer activities of some medicinal plants–biochemical perspectives

2021 ◽  
Vol 0 (0) ◽  
Author(s):  
Patrick E. Aba ◽  
John I. Ihedioha ◽  
Isaac U. Asuzu
Keyword(s):  
Medicinal Plants ◽  
Adverse Side Effects ◽  
Safety Margins ◽  
Management Procedures ◽  
Anti Cancer ◽  
Long Time ◽  
Cell Cycle Inhibition ◽  
Anti Oxidant ◽  
Induction Of Apoptosis ◽  
Plant Compounds

Abstract Cancer is a disease resulting in unbridled growth of cells due to dysregulation in the balance of cell populations. Various management procedures in handling cases of cancer are not without their adverse side effects on the normal cells. Medicinal plants/herbs have been in use in the management of various ailments, including cancer, for a long time. Medicinal plants have been credited with wide safety margins, cost effectiveness, availability and diverse activities. This study reviewed various mechanisms of anti-cancer activities of some medicinal plants from a biochemical perspective. The mechanisms of anti-cancer activities of plant compounds addressed in this article include induction of apoptosis, anti-angiogenic effects, anti-metastasis, inhibition of cell cycle, inhibition of DNA destruction and effects on key enzymes, cytotoxic and anti-oxidant effects. The anti-cancer activities of some of the plants involve more than one mechanism.

scholarly journals A Perspective on Withania somnifera Modulating Antitumor Immunity in Targeting Prostate Cancer

2021 ◽  
Vol 2021 ◽  
pp. 1-11
Author(s):  
Seema Dubey ◽  
Manohar Singh ◽  
Ariel Nelson ◽  
Dev Karan
Keyword(s):  
Prostate Cancer ◽  
Medicinal Plants ◽  
Bioactive Compounds ◽  
Antitumor Immunity ◽  
Withania Somnifera ◽  
Early Stage ◽  
Natural Killer Cell Activity ◽  
Killer Cell ◽  
Cell Activity

Medicinal plants serve as a lead source of bioactive compounds and have been an integral part of day-to-day life in treating various disease conditions since ancient times. Withaferin A (WFA), a bioactive ingredient of Withania somnifera, has been used for health and medicinal purposes for its adaptogenic, anti-inflammatory, and anticancer properties long before the published literature came into existence. Nearly 25% of pharmaceutical drugs are derived from medicinal plants, classified as dietary supplements. The bioactive compounds in these supplements may serve as chemotherapeutic substances competent to inhibit or reverse the process of carcinogenesis. The role of WFA is appreciated to polarize tumor-suppressive Th1-type immune response inducing natural killer cell activity and may provide an opportunity to manipulate the tumor microenvironment at an early stage to inhibit tumor progression. This article signifies the cumulative information about the role of WFA in modulating antitumor immunity and its potential in targeting prostate cancer.

Phytochemical Analyses and Activity of Herbal Medicinal Plants of North- East India for Anti-Diabetic, Anti-Cancer and Anti-Tuberculosis and their Docking Studies

2015 ◽  
Vol 15 (1) ◽  
pp. 21-36 ◽  
Author(s):  
Sivasubramanian Suhitha ◽  
Seenivasan Devi ◽  
Krishnasamy Gunasekaran ◽  
H. Pakyntein ◽  
Atanu Bhattacharjee ◽  
...  
Keyword(s):  
Medicinal Plants ◽  
Docking Studies ◽  
North East India ◽  
North East ◽  
Anti Cancer ◽  
Herbal Medicinal

Study on Trace Elements Concentration in Medicinal Plants Using EDXRF Technique

2020 ◽  
Vol 198 (1) ◽  
pp. 293-302 ◽  
Author(s):  
Chandrashekara Kulal ◽  
Ranjib Kumar Padhi ◽  
Kanagasabapathy Venkatraj ◽  
Kamala Kantha Satpathy ◽  
Somashekarappa Hiriyuru Mallaya
Keyword(s):  
Trace Elements ◽  
Medicinal Plants ◽  
Edxrf Technique

ANALYSIS OF TRACE ELEMENTS IN PRE- AND POST-NATAL TOOTH ENAMEL USING MICRO-PIXE

2012 ◽  
Vol 22 (01n02) ◽  
pp. 101-106 ◽  
Author(s):  
K. IGARI ◽  
A. TAKAHASHI ◽  
N. GOTOH ◽  
K. SASAKI ◽  
K. ISHII ◽  
...  
Keyword(s):  
Trace Elements ◽  
Environmental Exposure ◽  
Developmental Disorders ◽  
Elemental Concentration ◽  
Tooth Enamel ◽  
The Other ◽  
Deciduous Teeth ◽  
Birth Complications ◽  
Trace Elemental ◽  
Elemental Maps

Naturally shed deciduous teeth are potentially useful as a biomarker of environmental exposure. To assess the prenatal environment of child, we tried to present the neonatal line on the elemental maps and investigate the trace elements in pre- and post-natally formed tooth enamel using micro-PIXE. Generally, the neonatal line is observed more clearly in the tooth from child who has some difficulties at birth. In this study, five deciduous teeth from five children with developmental disorders were used for analysis. Seven trace elements ( Na , Mg , Si , Cl , Fe , Zn , and Sr ) were detected in enamel of all five teeth. The line, it was thought neonatal line, was observed on the elemental map of Ca and P in the tooth from the child with serious birth complications. In order to compare the elemental concentration between pre- and post-natal enamel, concentration variation of elements were projected along the line perpendicular to the neonatal line. Lower Ca concentration in prenatal enamel was observed. By tracing the location of neonatal line on the other elemental maps, the concentrations of detected trace elements were compared in the same way. The differences of concentration of these trace elements between pre- and post-natal enamel were not clear because of much statistic variation. We could determine the trace elemental profiles and concentrations around the neonatal line in the enamel from the child with serious birth complications.

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