Escherichia coli mismatch repair protein MutL interacts with the clamp loader subunits of DNA polymerase III

2008 ◽  
Vol 637 (1-2) ◽  
pp. 101-110 ◽  
Author(s):  
Feng Li ◽  
Qin Liu ◽  
Yuan-Yuan Chen ◽  
Zi-Niu Yu ◽  
Zhi-Ping Zhang ◽  
...  
Keyword(s):  
Escherichia Coli ◽  
Mismatch Repair ◽  
Dna Polymerase ◽  
Dna Polymerase Iii ◽  
Clamp Loader ◽  
Polymerase Iii ◽  
Repair Protein ◽  
Mismatch Repair Protein

scholarly journals Solution study of the Escherichia coli DNA polymerase III clamp loader reveals the location of the dynamic ψχ heterodimer

2015 ◽  
Vol 2 (5) ◽  
pp. 054701 ◽  
Author(s):  
Farzaneh Tondnevis ◽  
Richard E. Gillilan ◽  
Linda B. Bloom ◽  
Robert McKenna
Keyword(s):  
Escherichia Coli ◽  
Dna Polymerase ◽  
Dna Polymerase Iii ◽  
Clamp Loader ◽  
Solution Study ◽  
Polymerase Iii

scholarly journals Protein trafficking on sliding clamps

2004 ◽  
Vol 359 (1441) ◽  
pp. 25-30 ◽  
Author(s):  
Francisco López de Saro ◽  
Roxana E. Georgescu ◽  
Frank Leu ◽  
Mike O'Donnell
Keyword(s):  
Escherichia Coli ◽  
Traffic Flow ◽  
Dna Polymerase ◽  
Protein Trafficking ◽  
Dna Structure ◽  
Dna Polymerase Iii ◽  
Clamp Loader ◽  
Polymerase Iii ◽  
Sliding Clamps

The sliding clamps of chromosomal replicases are acted upon by both the clamp loader and DNA polymerase. Several other proteins and polymerases also interact with the clamp. These proteins bind the clamp at the same spot and use it in sequential fashion. First the clamp loader must bind the clamp in order to load it onto DNA, but directly thereafter the clamp loader must clear away from the clamp so it can be used by the replicative DNA polymerase. At the end of replication, the replicase is ejected from the clamp, which presumably allows the clamp to interact with yet other proteins after its use by the replicase. This paper describes how different proteins in the Escherichia coli replicase, DNA polymerase III holoenzyme, coordinate their traffic flow on the clamp. The mechanism by which traffic flow on the β; clamp is directed is based on competition of the proteins for the clamp, where DNA structure modulates the competition. It seems likely that the principles will generalize to a traffic flow of other factors on these circular clamp proteins.

scholarly journals Nucleotide-Induced Conformational Changes in an Isolated Escherichia coli DNA Polymerase III Clamp Loader Subunit

Structure ◽  
2003 ◽  
Vol 11 (3) ◽  
pp. 253-263 ◽  
Author(s):  
Marjetka Podobnik ◽  
Tanya F. Weitze ◽  
Mike O'Donnell ◽  
John Kuriyan
Keyword(s):  
Escherichia Coli ◽  
Dna Polymerase ◽  
Conformational Changes ◽  
Dna Polymerase Iii ◽  
Clamp Loader ◽  
Polymerase Iii

scholarly journals Lethality of bypass polymerases in Escherichia coli cells with a defective clamp loader complex of DNA polymerase III

2003 ◽  
Vol 50 (1) ◽  
pp. 193-204 ◽  
Author(s):  
Enrique Viguera ◽  
Mirjana Petranovic ◽  
Davor Zahradka ◽  
Karine Germain ◽  
Dusko S. Ehrlich ◽  
...  
Keyword(s):  
Escherichia Coli ◽  
Dna Polymerase ◽  
Dna Polymerase Iii ◽  
Clamp Loader ◽  
Escherichia Coli Cells ◽  
Polymerase Iii

scholarly journals The interaction of DNA polymerase III and the product of the Escherichia coli mutator gene, mutD.

1984 ◽  
Vol 259 (9) ◽  
pp. 5567-5573
Author(s):  
R DiFrancesco ◽  
S K Bhatnagar ◽  
A Brown ◽  
M J Bessman
Keyword(s):  
Escherichia Coli ◽  
Dna Polymerase ◽  
Dna Polymerase Iii ◽  
Mutator Gene ◽  
Polymerase Iii
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