Altered placental function in the tryptophan hydroxylase 1 knock-out mouse – From fetal development in utero to erythropoiesis in post-natal life

Placenta ◽  
2014 ◽  
Vol 35 (9) ◽  
pp. A8 ◽  
Author(s):  
Kathy Deroy ◽  
France Côté ◽  
Thomas Sanderson ◽  
Cathy Vaillancourt
Keyword(s):  
Fetal Development ◽  
Tryptophan Hydroxylase ◽  
In Utero ◽  
Knock Out ◽  
Placental Function ◽  
Knock Out Mouse

Brain immune cells characterization in UCMS exposed P2X7 knock-out mouse

2021 ◽  
Vol 94 ◽  
pp. 159-174
Author(s):  
Romain Troubat ◽  
Samuel Leman ◽  
Katleen Pinchaud ◽  
Alexandre Surget ◽  
Pascal Barone ◽  
...  
Keyword(s):  
Immune Cells ◽  
Knock Out ◽  
Knock Out Mouse

scholarly journals A Potential Role and Contribution of Androgens in Placental Development and Pregnancy

Life ◽  
2021 ◽  
Vol 11 (7) ◽  
pp. 644
Author(s):  
Agata M. Parsons ◽  
Gerrit J. Bouma
Keyword(s):  
Fetal Development ◽  
Fetal Loss ◽  
Membrane Receptors ◽  
Placental Development ◽  
Placental Function ◽  
Fetal Physiology ◽  
Estrogen Synthesis ◽  
And Function ◽  
Pregnancy Disorders

Successful pregnancy requires the establishment of a highly regulated maternal–fetal environment. This is achieved through the harmonious regulation of steroid hormones, which modulate both maternal and fetal physiology, and are critical for pregnancy maintenance. Defects in steroidogenesis and steroid signaling can lead to pregnancy disorders or even fetal loss. The placenta is a multifunctional, transitory organ which develops at the maternal–fetal interface, and supports fetal development through endocrine signaling, the transport of nutrients and gas exchange. The placenta has the ability to adapt to adverse environments, including hormonal variations, trying to support fetal development. However, if placental function is impaired, or its capacity to adapt is exceeded, fetal development will be compromised. The goal of this review is to explore the relevance of androgens and androgen signaling during pregnancy, specifically in placental development and function. Often considered a mere precursor to placental estrogen synthesis, the placenta in fact secretes androgens throughout pregnancy, and not only contains the androgen steroid nuclear receptor, but also non-genomic membrane receptors for androgens, suggesting a role of androgen signaling in placental function. Moreover, a number of pregnancy disorders, including pre-eclampsia, gestational diabetes, intrauterine growth restriction, and polycystic ovarian syndrome, are associated with abnormal androgen levels and androgen signaling. Understanding the role of androgens in the placenta will provide a greater understanding of the pathophysiology of pregnancy disorders associated with androgen elevation and its consequences.

scholarly journals Dorsal raphe serotonin neurotransmission is required for the expression of nursing behavior and for pup survival

2021 ◽  
Vol 11 (1) ◽  
Author(s):  
Aude Muzerelle ◽  
Mariano Soiza-Reilly ◽  
Cornelia Hainer ◽  
Pierre-Louis Ruet ◽  
Klaus-Peter Lesch ◽  
...  
Keyword(s):  
Tryptophan Hydroxylase ◽  
Dorsal Raphe ◽  
Normal Mammary Gland ◽  
Knock Out ◽  
Maternal Experience ◽  
Pup Retrieval ◽  
Pup Survival ◽  
Gland Development ◽  
Severe Growth ◽  
Dorsal Raphé

AbstractProper maternal care is an essential factor of reproductive success in mammals, involving a repertoire of behaviors oriented toward the feeding and care of the offspring. Among the neurotransmitters involved in the initiation of these behaviors, serotonin (5-HT) seems to play an important role. Here we compared pup-oriented maternal behaviors in mice with constitutive 5-HT depletion, the tryptophan hydroxylase 2-knock-out (Tph2-KO) and the Pet1-KO mice. We report that the only common pup-oriented defect in these 2 hyposerotoninergic models is a defective nursing in parturient mice and altered nursing-like (crouching) behavior in virgin mice, while pup retrieval defects are only present in Tph2-KO. Despite a normal mammary gland development and milk production, the defect in appropriate nursing is responsible for severe growth retardation and early lethality of pups born to hyposerotonergic dams. This nursing defect is due to acute rather constitutive 5-HT depletion, as it is reproduced by adult knockdown of Tph2 in the dorsal raphe nucleus in mothers with a prior normal maternal experience. We conclude that 5-HT innervation from the dorsal raphe is required for both the initiation and maintenance of a normal nursing behavior. Our findings may be related to observations of reduced maternal/infant interactions in human depression.

scholarly journals Mouse Mast Cell Protease-4-dependent production of ET-1 (1-31) and of plaque progression in an/INS; Apolipoprotein E knock-out mouse model of spontaneous atherosclerosis

Life Sciences ◽  
2013 ◽  
Vol 93 (25-26) ◽  
pp. e57
Author(s):  
Martin Houde ◽  
Walid Semaan ◽  
Louisane Desbiens ◽  
Zhipeng You ◽  
Adel G. Schwertani ◽  
...  
Keyword(s):  
Mast Cell ◽  
Mouse Model ◽  
Apolipoprotein E ◽  
Plaque Progression ◽  
Knock Out ◽  
Mast Cell Protease ◽  
Mouse Mast Cell ◽  
Knock Out Mouse

scholarly journals A Potential Compensatory Role of Panx3 in the VNO of a Panx1 Knock Out Mouse Model

2018 ◽  
Vol 11 ◽  
Author(s):  
Paige Whyte-Fagundes ◽  
Stefan Kurtenbach ◽  
Christiane Zoidl ◽  
Valery I. Shestopalov ◽  
Peter L. Carlen ◽  
...  
Keyword(s):  
Mouse Model ◽  
Knock Out ◽  
Knock Out Mouse

Expression of globular form acetylcholinesterase is not altered in P2Y1R knock-out mouse brain

2016 ◽  
Vol 259 ◽  
pp. 291-294 ◽  
Author(s):  
Jane D. Cui ◽  
Miranda L. Xu ◽  
Etta Y.L. Liu ◽  
Tina T.X. Dong ◽  
H.Q. Lin ◽  
...  
Keyword(s):  
Mouse Brain ◽  
Knock Out ◽  
Globular Form ◽  
Knock Out Mouse

Prevention of urinary bladder cancer in the FHIT knock-out mouse with Rofecoxib, a Cox-2 inhibitor

2010 ◽  
Vol 28 (2) ◽  
pp. 189-194 ◽  
Author(s):  
Domenico D'Arca ◽  
James LeNoir ◽  
Bernadette Wildemore ◽  
Fedra Gottardo ◽  
Emma Bragantini ◽  
...  
Keyword(s):  
Bladder Cancer ◽  
Urinary Bladder ◽  
Urinary Bladder Cancer ◽  
Knock Out ◽  
Cox 2 ◽  
Knock Out Mouse
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