HELLP syndrome in severe preeclampsia: The perinatal outcomes

Objective: To determine the efficacy of periodontal intervention on pregnancy outcome in mild preeclamptic women. Methods: A sample of 60 pregnant women with mild preeclampsia (blood pressure levels < 160/110 mm and proteinuria >300 mg/l in 24 hours urine) from the Hospital Universitario del Valle (Cali, Colombia) was included to the study. Preeclamptic women were randomized in two groups, one with periodontal intervention (PIG, N=28) and another in which the periodontal intervention was practiced after childbirth (NPIG, N=32). Maternal socio-demographic, medical and periodontal data were obtained. PIG included patients in which supragingival and subgingival cleaning within ultrasonic and manual devices were performed after study inclusion. The progression from mild to severe preeclampsia, eclampsia or HELLP syndrome, the number of days of clinical stability and the percentile of birth-weight adjusted for gestational age were evaluated in both groups. Results: Most of the patients (60%) were multigravids. Gestational age at inclusion was 31.8±1.6 weeks. Chronic periodontitis was a frequent finding (61.7%). Social, demographic, medical and periodontal conditions were similar between both groups. Disease progression to severe preeclampsia, eclampsia or HELLP syndrome was also similar (89.2% PIG versus 84.4%, p=0.65) (OR=1.06 IC 95% 0.87-1.29, p=0.65). Days of clinical stability were similar between the groups (median 10 days , range 1-46, PIG versus 12 days, range 1-59, p=0.57) and the percentile of birth weight adjusted with gestational age had no differences between the groups (median percentil 50 range 5-90 PIG versus percentil 55 range 5-95, p=0.73). Conclusion: Periodontal intervention does not seem to harm the health, the severity or alter the frequency on maternal complications in mild preeclampsia subjects.

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Maternal and neonatal consequences in women with severe preeclampsia and patients with HELLP syndrome: a comparative study

Obstetrics & Gynecology International Journal ◽

10.15406/ogij.2020.11.00518 ◽

2020 ◽

Vol 11 (4) ◽

Author(s):

Ahmed SSA Rashwan

Keyword(s):

Hellp Syndrome ◽

Statistical Significance ◽

Health Hazard ◽

Severe Preeclampsia ◽

University Hospital ◽

Definitive Treatment ◽

Icu Admission ◽

Institutional Review ◽

Elevated Liver Enzymes ◽

Multiple Drugs

Background: The (HELLP) syndrome is a severe health hazard in pregnancy described by elevated liver enzymes, low platelet count and hemolysis. It happens in 0.4 to 0.7% of all gestations and in 10-12% of cases with severe preeclampsia. Patients and methods: The present study was a prospective observational study that was made at Department of Obstetrics and Gynecology, Kasr Al-Ainy University Hospital, Cairo University, from September 2018 – March 2019. It included One Hundred and Thirty pregnant women diagnosed with hypertension in the current pregnancy complicated with severe preeclampsia, or HELLP Syndrome associated with abdominal ascites, recruited from the attendees of the Obstetric Emergency Department. The study was approved by the local institutional review board of the Faculty of Medicine, Cairo University. All ladies signed an informed consent. Results: There were statistically significant differences between the HELLP group and the severe preeclamptic group regarding maternal ICU admission and the need of multiple drugs to control the blood pressure being less in severe preeclampsia group. The need for ICU admission was much higher in the HELLP group (43.1%) compared to the severe preeclampsia group (9.2%) showing statistical significance (P<0.001). Conclusion: Maternal and neonatal sicknesses are elevated between cases with HELLP syndrome. So, early diagnosis and definitive treatment can be made to enhance maternal and neonatal results.

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Profil pasien preeklamsia berat dan eklamsia di ICU dan HCU RSUP Prof. Dr. R. D. Kandou Manado

e-CliniC ◽

10.35790/ecl.4.2.2016.14461 ◽

2016 ◽

Vol 4 (2) ◽

Author(s):

Vania Nita Patty ◽

Diana Ch. Lalenoh ◽

Debby D. Wuisan

Keyword(s):

Medical Records ◽

Hellp Syndrome ◽

Seizure Activity ◽

Study Data ◽

Severe Preeclampsia ◽

Inclusion Criteria ◽

Median Length ◽

Hypertension In Pregnancy ◽

Grand Mal ◽

New Onset

Abstract: Preeclampsia was defined as hypertension in pregnancy that occurs after 20th weeks of pregnancy meanwhile eclampsia is the new onset of a grand mal seizure activity and is one of the complications of preeclampsia. Preeclampsia and eclampsia are still the major causes of high maternal and infant mortality in Indonesia (1.5% -25%). Severe preeclampsia becomes an indication of obstetric patients to be admitted to ICU. This study was aimed to obtain the profile of patients with severe preeclampsia and eclampsia admitted to the ICU and HCU Prof. Dr. R.D. Kandou Hospital. This was a descriptive retrospective study. Data were obtained from the medical records of patients admitted to the ICU and HCU from September 2014 to August 2016. There were 33 patients that met the inclusion criteria consisted of 11 patients (33%) with severe preeclampsia and 22 patients (67%) with eclampsia. Most patients were aged ≤ 25 years and the median length of stay in this study was 2 days. HELLP syndrome was found in 9 patients (27.3%) and DIC in 1 (3%) patient. There were five patients with ventilator and three patients died due to eclampsia. Conclusion: Most patients in this study were patients with eclampsia and the mortality rate was 9.1%.Keywords: severe preeclampsia, eclampsia, ICU, HCU Abstrak: Preeklamsia didefinisikan sebagai hipertensi dalam kehamilan yang terjadi setelah minggu ke- 20 kehamilan, sedangkan eklamsia adalah onset baru aktifitas kejang grand mal dan merupakan salah satu komplikasi dari preeklamsia. Preeklamsia dan eklamsia masih menjadi penyebab utama tingginya angka kematian ibu dan bayi di Indonesia (1,5%-25%). Preeklamsia berat menjadi indikasi pasien obstetri masuk ke ICU. Penelitian ini bertujuan untuk mengetahui gambaran pasien preeklamsia berat dan eklamsia yang dirawat di ICU dan HCU RSUP Prof. Dr. R.D. Kandou. Jenis penelitian ialah deskriptif retrospektif. Data diperoleh melalui data rekam medik pasien yang dirawat di ICU dan HCU periode September 2014 - Agustus 2016 dan didapatkan sebanyak 33 pasien yang memenuhi kriteria inklusi. Total pasien preeklamsia berat ialah 11 orang (33%) dan eklamsia sebanyak 22 orang (67%). Usia ≤25 tahun ialah usia terbanyak dan median lama rawat dalam penelitian ini ialah 2 hari. Kejadian HELLP syndrome pada kasus ini sebanyak 9 orang (27,3%) dan DIC sebanyak 1 orang (3%). Pasien dengan ventilator sebanyak 5 orang dan pasien yang meninggal akibat eklamsia sebanyak 3 orang. Simpulan: Dalam penelitian ini pasien terbanyak ialah pasien eklamsia dengan angka kematian 9,1%. Kata kunci: preeklamsia berat, eklamsia, ICU, HCU

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