The compact spinning system with a lattice apron utilizes air-flow dynamics to condense fibers in a bunch and enhance the yarn properties. One of the main challenges with this method is the lack of a comprehensive understanding of the air-flow field's effect in the condensing zone. This work presents a numerical and experimental investigation of the effects of three-dimensional (3D) printed guiding devices on the air-flow characteristics and yarn properties. Firstly, the 3D numerical model of the compact spinning system was set up based on the compact spinning machine geometrical dimensions. Secondly, different 3D prototypes were developed, simulated, and analyzed using computational fluid dynamics based on ANSYS software. The prototypes (A-type, B-type, and C-type), selected according to the simulation results, were then 3D printed to enable further experimental investigation. Air-flow analysis results in the air-suction flume area exhibiting a very high negative pressure, and the centerline zone was characterized by high velocity. Experimental results revealed that the three yarns spun with guiding devices had better strength, hairiness, and evenness than those spun without a guiding device. The model developed can be further improved and utilized for commercial purposes and is anticipated to improve compact spun yarn properties significantly.