Cyclones are widely used for separating particles from gas in energy production objects. The efficiency of conventional centrifugal air cleaning devices ranges from 85 to 90%, but the weakness of many cyclones is the low collection efficiency of particles less than 10 μm in diameter. The novelty of this work is the research of the channel-type treatment device, with few levels adapted for precipitation of fine particulate matter, acting by a centrifugal and filtration principle. Many factors have an impact on cyclone efficiency—humidity, temperature, gas (air) composition, airflow velocity and etc. Many scientists evaluated only the effect of origin and size of PM on cyclone efficiency. The effect of gas (air) composition and temperature, and humidity on the multi-channel cyclone-separator efficiency still demands contributions. Complex theoretical and experimental research on air flow parameters and the efficiency of a cylindrical eight-channel system with adjustable half-rings for removing fine-dispersive particles (<20 μm) was carried out. The impact of air humidity and temperature on air flow, and gaseous smoke components on the removal of wood ashes was analyzed. The dusty gas flow was regulated. During the experiment, the average velocity of the cyclone was 16 m/s, and the temperature was 20–50 °C. The current paper presents experimental research results of wood ash removal in an eight-channel cyclone and theoretical methodology for the calculation of airflow parameters and cyclone effectiveness.