Neonatal paternal deprivation disrupts endocrine-immune balance in adult California mice (Peromyscus californicus)

2019 ◽  
Vol 100 ◽  
pp. S59
Author(s):  
Erica R. Glasper ◽  
Sabina Khantsis ◽  
Shakeera L. Walker
Author(s):  
Vanessa A. Minie ◽  
Radmila Petric ◽  
Stephanie Ramos-Maciel ◽  
Emily C. Wright ◽  
Brian C. Trainor ◽  
...  

2021 ◽  
Author(s):  
Vanessa Minie ◽  
Stephanie Ramos-Maciel ◽  
Emily Wright ◽  
Radmila Petric ◽  
Brian Trainor ◽  
...  

AbstractDomesticated mice and rats have shown to be powerful model systems for biomedical research, but there are cases in which the biology of species is a poor match for the hypotheses under study. The California mouse (Peromyscus californicus) has unique physiological and behavioral traits and has emerged as a powerful model for studying sex differences in the biology of psychiatric disease, which is particularly relevant considering the new NIH guidelines that require the inclusion of sex as a biological variable. Despite its growing role in preclinical research, there is a lack of studies assessing species-specific housing needs, which presents a challenge for research facilities seeking to ensure good welfare and obtaining high-quality experimental data. Indeed, captive California mice present a high prevalence of stereotypic backflipping behavior, a common consequence of suboptimal housing and a potential source of experimental outcome variability. Using three different cage systems, the present studies show that increasing housing space as well as social and environmental complexity can delay the development of stereotypic behavior in male and female California mice. Critically, this reduction in stereotypy is accompanied by increased effect sizes of stress in an established model for social anxiety. These results suggest that increased cage size and enrichment could enhance welfare in California mice while simultaneously increasing the quality of behavioral experiments.


PLoS ONE ◽  
2013 ◽  
Vol 8 (2) ◽  
pp. e55698 ◽  
Author(s):  
Scott A. Williams ◽  
Eldin Jasarevic ◽  
Gregory M. Vandas ◽  
Denise A. Warzak ◽  
David C. Geary ◽  
...  

PLoS ONE ◽  
2012 ◽  
Vol 7 (8) ◽  
pp. e43881 ◽  
Author(s):  
Nadia F. Gallardo-Romero ◽  
Clifton P. Drew ◽  
Sonja L. Weiss ◽  
Maureen G. Metcalfe ◽  
Yoshinori J. Nakazawa ◽  
...  

PLoS ONE ◽  
2010 ◽  
Vol 5 (4) ◽  
pp. e9705 ◽  
Author(s):  
Matina C. Kalcounis-Rueppell ◽  
Radmila Petric ◽  
Jessica R. Briggs ◽  
Catherine Carney ◽  
Matthew M. Marshall ◽  
...  

2021 ◽  
Author(s):  
Janet K. Bester‐Meredith ◽  
Jennifer N. Burns ◽  
Minh N. Dang ◽  
Alexandrea M. Garcia ◽  
Grace E. Mammarella ◽  
...  

Sign in / Sign up

Export Citation Format

Share Document