A hemoglobin-based oxygen carrier, bovine polymerized hemoglobin (HBOC-201) versus hetastarch (HEX) in a moderate severity hemorrhagic shock swine model with delayed evacuation

Resuscitation ◽  
2005 ◽  
Vol 66 (3) ◽  
pp. 367-378 ◽  
Author(s):  
Nora Philbin ◽  
Jennifer Rice ◽  
Jennifer Gurney ◽  
Gerald McGwin ◽  
Françoise Arnaud ◽  
...  
Keyword(s):  
Hemorrhagic Shock ◽  
Oxygen Carrier ◽  
Swine Model ◽  
Moderate Severity ◽  
Polymerized Hemoglobin

BOVINE POLYMERIZED HEMOGLOBIN VERSUS HEXTEND RESUSCITATION IN A SWINE MODEL OF SEVERE CONTROLLED HEMORRHAGIC SHOCK WITH DELAY TO DEFINITIVE CARE

Shock ◽  
2006 ◽  
Vol 26 (3) ◽  
pp. 302-310 ◽  
Author(s):  
Jennifer Rice ◽  
Nora Philbin ◽  
Gerald McGwin ◽  
Fran??oise Arnaud ◽  
Todd Johnson ◽  
...  
Keyword(s):  
Hemorrhagic Shock ◽  
Swine Model ◽  
Polymerized Hemoglobin

A Comparison of the Hemoglobin-Based Oxygen Carrier HBOC-201 to Other Low-Volume Resuscitation Fluids in a Model of Controlled Hemorrhagic Shock

2003 ◽  
Vol 55 (4) ◽  
pp. 747-754 ◽  
Author(s):  
CPT James B. Sampson ◽  
CPT Michael R. Davis ◽  
MAJ Deborah L. Mueller ◽  
LT Vikram S. Kashyap ◽  
LT Donald H. Jenkins ◽  
...  
Keyword(s):  
Hemorrhagic Shock ◽  
Oxygen Carrier ◽  
Volume Resuscitation ◽  
Low Volume

Abstract 4030: Resuscitation with Intraosseous Infusion of Artificial Oxygen Carrier of Liposome-Encapsulated Hemoglobin (LHb) from Lethal Hemorrhagic Shock and Its Effect on Cytokines

Circulation ◽  
2008 ◽  
Vol 118 (suppl_18) ◽  
Author(s):  
Bonpei Takase ◽  
Satoshi Shono ◽  
Manabu Kinoshita ◽  
Yashiro Nogami ◽  
Yoshitaka Ogata ◽  
...  
Keyword(s):  
Renal Function ◽  
Side Effects ◽  
Hemorrhagic Shock ◽  
Oxygen Carrier ◽  
Femoral Vein ◽  
Survival Rates ◽  
Blood Substitute ◽  
Disaster Medicine ◽  
Mice Model ◽  
Artificial Oxygen Carrier

Liposome-encapsulated hemoglobin (LHb), which is structurally similar to red blood cells (RBC) except smaller size (250 nm), can serve as blood substitute comparable to RBC. We have reported that intraosseous blood infusion (IOI) is effective treatment in shock mice model. IOI is alternative to peripheral i.v. infusion and is expected as an important field treatment in civilian emergency because of no collapse of intramedullary blood vessels in the bone marrow in shock. However, we did not evaluate the side effects of LHb in IOI. Total 70% hemorrhagic shock was induced by femoral vein bleeding. Immediately after bleeding, 17 mice were resuscitated with tibial bone IOI of 5% albumin (5% albumin), 18 mice resuscitated with mouse-washed RBC (Wash RBC) and 14 mice resuscitated with LHb (LHb-group). Survival rates were compared and the temporal changes in cytokins (TNF, INFγ) as well as liver and renal function (s-ALT, s-creatinine) were measured. All mice survived 48 h after IOI of LHb whereas only 47% and 45% mice survived in 5% albumin and Wash RBC, respectively (Fig. 1 ). The changes in TNF and INFγlevels after IOI were not statistically different among 3 groups (Fig. 2 ) and no side effects were found on liver and renal function.. Conclusions: LHb has a better anti-shock effect than RBC by using IOI probably due to smaller size and IOI of LHb could be useful in disaster medicine. In addition, IOI of LHb shows no significant effects on cytokins, liver and renal function. Figure 1 Figure 2

Controlled Polymerization and Ultrafiltration Increase the Consistency of Polymerized Hemoglobin for Use as an Oxygen Carrier

2019 ◽  
Vol 31 (3) ◽  
pp. 605-621 ◽  
Author(s):  
Donald A. Belcher ◽  
Clayton T. Cuddington ◽  
Evan L. Martindale ◽  
Ivan S. Pires ◽  
Andre F. Palmer
Keyword(s):  
Oxygen Carrier ◽  
Controlled Polymerization ◽  
Polymerized Hemoglobin
Sign in / Sign up

Export Citation Format

Share Document