Microwave-assisted solid phase conversion study of Meldrum's acid to ethylenetetracarboxylic dianhydride (C6O6)

2010 ◽  
Vol 75 (1) ◽  
pp. 493-497 ◽  
Author(s):  
Avat (Arman) Taherpour
Keyword(s):  
Solid Phase ◽  
Phase Conversion ◽  
Meldrum's Acid ◽  
Meldrum’S Acid ◽  
Microwave Assisted ◽  
Conversion Study

MicrowavE Assisted hydrolysis of Meldrum'S Acid Derivatives and decarboxylation of Derived Malonic Acids

2003 ◽  
Vol 2003 (3) ◽  
pp. 174-175 ◽  
Author(s):  
V.B. Helavi ◽  
S.B. Solabannavar ◽  
U.V. Desai ◽  
R.B. Mane
Keyword(s):  
Carboxylic Acids ◽  
Meldrum's Acid ◽  
Meldrum’S Acid ◽  
Microwave Assisted ◽  
High Yields ◽  
Short Time ◽  
Hydrolysis Of ◽  
Meldrum's Acid Derivatives

Microwave induced hydrolysis of alkyl Medrum's acids and decarboxylation of derived malonic acids using poly-4-vinylpyridine as a catalyst gives high yields of carboxylic acids in a short time.

Integration of C-Acylation in the Solid-Phase Synthesis of Peptides and Peptidomimetics employing Meldrum’s Acid, Phosphorus and Sulfur Ylides

Synthesis ◽  
2021 ◽  
Author(s):  
Ahsanullah Ahsanullah ◽  
Abbas Hassan ◽  
Farzana Latif Anzari ◽  
Jörg Rademann
Keyword(s):  
Peptide Synthesis ◽  
Medicinal Chemistry ◽  
Solid Phase Synthesis ◽  
Solid Phase ◽  
Meldrum's Acid ◽  
Important Goal ◽  
Meldrum’S Acid ◽  
Phase Synthesis ◽  
Sulfur Ylides ◽  
Native Peptides

Modification of native peptides to peptidomimetics is an important goal in medicinal chemistry and requires in many cases the integration of C-acylation steps involving amino acids with peptide synthesis. Many classical C-acylation protocols involving Claisen condensations or the use of ylides are not compatible with peptide synthesis, mostly due to the requirement of strong bases leading to epimerization or deprotection of peptides. Meldrum’s acid as well as several specific phosphorus and sulfur ylides, however, are acidic enough to provide reactive C-nucleophiles at mildly basic conditions tolerated during peptide synthesis. This review provides an overview of peptide-compatible C-acylations of Meldrum´s acid, phosphorus and sulfur ylides and their application in the medicinal chemistry of peptides.

An Expeditious One-Pot Three-Component Synthesis of 4-Aryl-3,4-dihydrobenzo[g] quinoline-2,5,10(1H)-triones under Green Conditions

2020 ◽  
Vol 23 (23) ◽  
pp. 2626-2634
Author(s):  
Saiedeh Kamalifar ◽  
Hamzeh Kiyani
Keyword(s):  
Reaction Medium ◽  
Meldrum's Acid ◽  
Meldrum’S Acid ◽  
One Pot ◽  
One Pot Synthesis ◽  
Substituted Benzaldehydes ◽  
High Yields ◽  
First Time ◽  
Green Conditions

: An efficient and facial one-pot synthesis of 4-aryl-3,4-dihydrobenzo[g]quinoline- 2,5,10(1H)-triones was developed for the first time. The process proceeded via the three-component cyclocondensation of 2-amino-1,4-naphthoquinone with Meldrum’s acid and substituted benzaldehydes under green conditions. The fused 3,4-dihydropyridin-2(1H)- one-ring naphthoquinones have been synthesized with good to high yields in refluxing ethanol as a green reaction medium. This protocol is simple and effective as well as does not involve the assistance of the catalyst, additive, or hazardous solvents.

scholarly journals Identification of VOCs in essential oils extracted using ultrasound- and microwave-assisted methods from sweet cherry flower

2021 ◽  
Vol 11 (1) ◽  
Author(s):  
Huimin Zhang ◽  
Hongguang Yan ◽  
Quan Li ◽  
Hui Lin ◽  
Xiaopeng Wen
Keyword(s):  
Essential Oil ◽  
Sweet Cherry ◽  
Dimethyl Sulfide ◽  
Solid Phase ◽  
Oil Yield ◽  
Gas Chromatography Mass Spectrometry ◽  
Process Conditions ◽  
Important Indicator ◽  
Microwave Assisted ◽  
Essential Oil Yield

AbstractThe floral fragrance of plants is an important indicator in their evaluation. The aroma of sweet cherry flowers is mainly derived from their essential oil. In this study, based on the results of a single-factor experiment, a Box–Behnken design was adopted for ultrasound- and microwave-assisted extraction of essential oil from sweet cherry flowers of the Brooks cultivar. With the objective of extracting the maximum essential oil yield (w/w), the optimal extraction process conditions were a liquid–solid ratio of 52 mL g−1, an extraction time of 27 min, and a microwave power of 435 W. The essential oil yield was 1.23%, which was close to the theoretical prediction. The volatile organic compounds (VOCs) of the sweet cherry flowers of four cultivars (Brooks, Black Pearl, Tieton and Summit) were identified via headspace solid phase microextraction (SPME) and gas chromatography–mass spectrometry (GC–MS). The results showed that a total of 155 VOCs were identified and classified in the essential oil from sweet cherry flowers of four cultivars, 65 of which were shared among the cultivars. The highest contents of VOCs were aldehydes, alcohols, ketones and esters. Ethanol, linalool, lilac alcohol, acetaldehyde, (E)-2-hexenal, benzaldehyde and dimethyl sulfide were the major volatiles, which were mainly responsible for the characteristic aroma of sweet cherry flowers. It was concluded that the VOCs of sweet cherry flowers were qualitatively similar; however, relative content differences were observed in the four cultivars. This study provides a theoretical basis for the metabolism and regulation of the VOCs of sweet cherry flowers.

scholarly journals Cover Feature: Cp*Rh(III)‐Catalyzed C8 C−H Alkylation of Quinoline N ‐Oxides with Diazo Meldrum's Acid (Eur. J. Org. Chem. 3/2021)

2021 ◽  
Vol 2021 (3) ◽  
pp. 325-325
Author(s):  
Malcolm P. Huestis ◽  
Jean‐Philippe Leclerc ◽  
Robin Larouche‐Gauthier ◽  
Samuel Aubert‐Nicol ◽  
Arun Yadav ◽  
...  
Keyword(s):  
Meldrum's Acid ◽  
Meldrum’S Acid

Microwave-Assisted Solid-Phase Synthesis (MASS): Parallel and Combinatorial Chemical Library Synthesis

ChemInform ◽  
2004 ◽  
Vol 35 (7) ◽  
Author(s):  
Fahad Al-Obeidi ◽  
Richard E. Austin ◽  
John F. Okonya ◽  
Daniel R. S. Bond
Keyword(s):  
Solid Phase Synthesis ◽  
Solid Phase ◽  
Library Synthesis ◽  
Chemical Library ◽  
Phase Synthesis ◽  
Microwave Assisted

Structural, Bioactivity, Molecular Docking, Spectroscopic and Electronic Properties of a Synthesized Meldrum's Acid Derivative

2021 ◽  
Vol 6 (19) ◽  
pp. 4698-4718
Author(s):  
Halil Gökce ◽  
Gökhan Alpaslan ◽  
Serdal Kaya ◽  
Nezaket Çakır
Keyword(s):  
Molecular Docking ◽  
Electronic Properties ◽  
Acid Derivative ◽  
Meldrum's Acid ◽  
Meldrum’S Acid
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