Interrater reliability of schizoaffective disorder compared with schizophrenia, bipolar disorder, and unipolar depression – A systematic review and meta-analysis

2016 ◽  
Vol 176 (2-3) ◽  
pp. 357-363 ◽  
Author(s):  
Hanno Santelmann ◽  
Jeremy Franklin ◽  
Jana Bußhoff ◽  
Christopher Baethge
Keyword(s):  
Systematic Review ◽  
Bipolar Disorder ◽  
Schizoaffective Disorder ◽  
Interrater Reliability ◽  
Meta Analysis ◽  
Unipolar Depression

scholarly journals Cellular calcium in bipolar disorder: systematic review and meta-analysis

2019 ◽  
Author(s):  
Paul J. Harrison ◽  
Nicola Hall ◽  
Arne Mould ◽  
Noura Al-Juffali ◽  
Elizabeth M. Tunbridge
Keyword(s):  
Systematic Review ◽  
Bipolar Disorder ◽  
Effect Size ◽  
Bipolar Depression ◽  
Meta Analysis ◽  
Calcium Signalling ◽  
Unipolar Depression ◽  
Medium Effect ◽  
Cellular Calcium ◽  
Intracellular Ca

AbstractCalcium signalling has long been implicated in bipolar disorder, especially by reports of altered intracellular calcium ion concentrations ([Ca2+]). However, the evidence has not been appraised critically. We carried out a systematic review and meta-analysis of studies of cellular calcium indices in bipolar disorder. 2281 records were identified and 117 screened, of which 32 were eligible and 21 were suitable for meta-analyses. The latter each involved up to 642 patients and 404 control subjects. We found that basal free intracellular [Ca2+] is increased in bipolar disorder, both in platelets and in lymphocytes. The effect size is 0.55, with an estimated elevation of 29%. It is observed in medication-free patients. It is present in mania and bipolar depression, but data are equivocal for euthymia. Cells from bipolar disorder individuals also show an enhanced [Ca2+] response to stimulation with 5-HT or thrombin, by an estimated 25%, with an effect size of 0.63. In studies which included other diagnoses, intracellular basal [Ca2+] was higher in bipolar disorder than in unipolar depression, but not significantly different from schizophrenia. Functional parameters of cellular Ca2+ (e.g. calcium transients), and neuronal [Ca2+], have been much less investigated, and no firm conclusions can be drawn. In summary, there is a robust, medium effect size elevation of basal and stimulated free intracellular [Ca2+] in bipolar disorder. The results suggest altered calcium functioning in the disorder, and encourage further investigations into the underlying mechanisms, and the implications for pathophysiology and therapeutics.

Clozapine in bipolar disorder: A systematic review and meta-analysis

2020 ◽  
Vol 125 ◽  
pp. 21-27 ◽  
Author(s):  
Andre Delgado ◽  
Jorge Velosa ◽  
Junyu Zhang ◽  
Serdar M. Dursun ◽  
Flavio Kapczinski ◽  
...  
Keyword(s):  
Systematic Review ◽  
Bipolar Disorder ◽  
Meta Analysis

scholarly journals Violent criminal behavior in the context of bipolar disorder: Systematic review and meta-analysis

2018 ◽  
Vol 239 ◽  
pp. 161-170 ◽  
Author(s):  
Norma Verdolini ◽  
Isabella Pacchiarotti ◽  
Cristiano A. Köhler ◽  
Maria Reinares ◽  
Ludovic Samalin ◽  
...  
Keyword(s):  
Systematic Review ◽  
Bipolar Disorder ◽  
Criminal Behavior ◽  
Meta Analysis ◽  
Violent Criminal
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