Conversion of protein net charge via chemical modification for highly sensitive prion detection using field effect transistor (FET) biosensor

2016 ◽  
Vol 230 ◽  
pp. 374-379 ◽  
Author(s):  
Shofarul Wustoni ◽  
Sho Hideshima ◽  
Shigeki Kuroiwa ◽  
Takuya Nakanishi ◽  
Yasuro Mori ◽  
...  
Sensors ◽  
2021 ◽  
Vol 21 (12) ◽  
pp. 4213
Author(s):  
Seong-Kun Cho ◽  
Won-Ju Cho

In this study, a highly sensitive and selective sodium ion sensor consisting of a dual-gate (DG) structured silicon nanowire (SiNW) field-effect transistor (FET) as the transducer and a sodium-selective membrane extended gate (EG) as the sensing unit was developed. The SiNW channel DG FET was fabricated through the dry etching of the silicon-on-insulator substrate by using electrospun polyvinylpyrrolidone nanofibers as a template for the SiNW pattern transfer. The selectivity and sensitivity of sodium to other ions were verified by constructing a sodium ion sensor, wherein the EG was electrically connected to the SiNW channel DG FET with a sodium-selective membrane. An extremely high sensitivity of 1464.66 mV/dec was obtained for a NaCl solution. The low sensitivities of the SiNW channel FET-based sodium ion sensor to CaCl2, KCl, and pH buffer solutions demonstrated its excellent selectivity. The reliability and stability of the sodium ion sensor were verified under non-ideal behaviors by analyzing the hysteresis and drift. Therefore, the SiNW channel DG FET-based sodium ion sensor, which comprises a sodium-selective membrane EG, can be applied to accurately detect sodium ions in the analyses of sweat or blood.


The Analyst ◽  
2019 ◽  
Vol 144 (8) ◽  
pp. 2611-2617 ◽  
Author(s):  
Xuepeng Wang ◽  
Yong Wang ◽  
Yifan Wu ◽  
Yin Xiao

A chiral sensor was successfully constructed by modifying an OFET gate with SH-β-CD.


2011 ◽  
Vol 11 (5) ◽  
pp. 1157-1161 ◽  
Author(s):  
Yuh-Hwa Chang ◽  
Yen-Sheng Lu ◽  
Yu-Liang Hong ◽  
Shangjr Gwo ◽  
J. Andrew Yeh

2018 ◽  
Vol 29 (43) ◽  
pp. 435502 ◽  
Author(s):  
Sigang Shi ◽  
Ruixue Hu ◽  
Enxiu Wu ◽  
Quanning Li ◽  
Xuejiao Chen ◽  
...  

2009 ◽  
Vol 48 (6) ◽  
pp. 06FJ04 ◽  
Author(s):  
Takashi Kudo ◽  
Toshihiro Kasama ◽  
Takeshi Ikeda ◽  
Yumehiro Hata ◽  
Shiho Tokonami ◽  
...  

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