A low TAFI activity and insufficient activation of fibrinolysis by both plasmin and neutrophil elastase promote organ dysfunction in disseminated intravascular coagulation associated with sepsis

2012 ◽  
Vol 130 (6) ◽  
pp. 906-913 ◽  
Author(s):  
Mineji Hayakawa ◽  
Atsushi Sawamura ◽  
Satoshi Gando ◽  
Subrina Jesmin ◽  
Sumiyoshi Naito ◽  
...  
Keyword(s):  
Organ Dysfunction ◽  
Disseminated Intravascular Coagulation ◽  
Neutrophil Elastase ◽  
Intravascular Coagulation

Disseminated intravascular coagulation in meningococcal sepsis

2003 ◽  
Vol 23 (03) ◽  
pp. 125-130 ◽  
Author(s):  
S. Zeerleder ◽  
R. Zürcher Zenklusen ◽  
C. E. Hack ◽  
W. A. Wuillemin
Keyword(s):  
Organ Dysfunction ◽  
Disseminated Intravascular Coagulation ◽  
Skin Necrosis ◽  
Multiple Organ ◽  
Meningococcal Sepsis ◽  
Multiple Organ Dysfunction ◽  
Intravascular Coagulation ◽  
Therapeutic Concepts ◽  
New Therapeutic Concepts ◽  
Coagulation And Fibrinolysis

SummaryWe report on a man (age: 49 years), who died from severe meningococcal sepsis with disseminated intravascular coagulation (DIC), multiple organ dysfunction syndrome and extended skin necrosis. We discuss in detail the pathophysiology of the activation of coagulation and fibrinolysis during sepsis. The article discusses new therapeutic concepts in the treatment of disseminated intravascular coagulation in meningococcal sepsis, too.

scholarly journals Purpura Fulminans following Thermal Injury

2013 ◽  
Vol 2013 ◽  
pp. 1-3 ◽  
Author(s):  
Jiongyu Hu ◽  
Xupin Jiang ◽  
Ting He ◽  
Qizhi Luo
Keyword(s):  
Organ Dysfunction ◽  
Disseminated Intravascular Coagulation ◽  
Thermal Injury ◽  
Purpura Fulminans ◽  
Multiple Organ ◽  
Multiple Organ Dysfunction ◽  
Small Children ◽  
Intravascular Coagulation ◽  
Intravascular Thrombosis ◽  
First Case

Purpura fulminans is a rare syndrome of intravascular thrombosis and hemorrhagic infarction of the skin, which is an unusual cutaneous manifestation of disseminated intravascular coagulation. It often occurs in small children and babies due to infection and/or sepsis, rarely in adults in clinic. We report the first case of deadly purpura fulminans following thermal injury in a 64-year-old Chinese woman. The purpura developed sharply and aggravated multiple organ dysfunction. The patient died of purpura fulminans, disseminated intravascular coagulation, and multiple organ dysfunction syndrome.

scholarly journals Sepsis-induced Coagulopathy and Disseminated Intravascular Coagulation

2020 ◽  
Vol 132 (5) ◽  
pp. 1238-1245 ◽  
Author(s):  
Toshiaki Iba ◽  
Jerrold H. Levy
Keyword(s):  
Early Detection ◽  
Diagnostic Criteria ◽  
Organ Dysfunction ◽  
Vascular Injury ◽  
Disseminated Intravascular Coagulation ◽  
Clinical Management ◽  
Common Complication ◽  
Intravascular Coagulation

Coagulopathy, a common complication with sepsis, contributes to vascular injury and organ dysfunction. Early detection using diagnostic criteria for sepsis-induced coagulopathy is important to consider for potential clinical management.

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