scholarly journals Is There an Independent Role of TERT and NF1 in High Grade Gliomas?

2020 ◽  
Vol 13 (2) ◽  
pp. 346-354 ◽  
Author(s):  
Evangelia Razis ◽  
Vassiliki Kotoula ◽  
Georgia-Angeliki Koliou ◽  
Kyriaki Papadopoulou ◽  
Eleni Vrettou ◽  
...  
Keyword(s):  
High Grade ◽  
High Grade Gliomas

scholarly journals Stereotactic Laser Interstitial Thermal Therapy for Recurrent High-Grade Gliomas

Neurosurgery ◽  
2016 ◽  
Vol 79 (suppl_1) ◽  
pp. S24-S34 ◽  
Author(s):  
Ian Lee ◽  
Steven Kalkanis ◽  
Constantinos G. Hadjipanayis
Keyword(s):  
Thermal Therapy ◽  
Neurological Deficits ◽  
Current Evidence ◽  
High Grade ◽  
Medline Search ◽  
Laser Interstitial Thermal Therapy ◽  
Ablation Volume ◽  
Treatment Paradigm ◽  
High Grade Gliomas

Abstract BACKGROUND: The value of maximal safe cytoreductive surgery in recurrent high-grade gliomas (HGGs) is gaining wider acceptance. However, patients may harbor recurrent tumors that may be difficult to access with open surgery. Laser interstitial thermal therapy (LITT) is emerging as a technique for treating a variety of brain pathologies, including primary and metastatic tumors, radiation necrosis, and epilepsy. OBJECTIVE: To review the role of LITT in the treatment of recurrent HGGs, for which current treatments have limited efficacy, and to discuss the possible role of LITT in the disruption of the blood-brain barrier to increase delivery of chemotherapy locoregionally. METHODS: A MEDLINE search was performed to identify 17 articles potentially appropriate for review. Of these 17, 6 reported currently commercially available systems and as well as magnetic resonance thermometry to monitor the ablation and, thus, were thought to be most appropriate for this review. These studies were then reviewed for complications associated with LITT. Ablation volume, tumor coverage, and treatment times were also reviewed. RESULTS: Sixty-four lesions in 63 patients with recurrent HGGs were treated with LITT. Frontal (n = 34), temporal (n = 14), and parietal (n = 16) were the most common locations. Permanent neurological deficits were seen in 7 patients (12%), vascular injuries occurred in 2 patients (3%), and wound infection was observed in 1 patient (2%). Ablation coverage of the lesions ranged from 78% to 100%. CONCLUSION: Although experience using LITT for recurrent HGGs is growing, current evidence is insufficient to offer a recommendation about its role in the treatment paradigm for recurrent HGGs.

scholarly journals Is it time to reconsider the role of irinotecan for the treatment of high-grade gliomas?

2018 ◽  
Vol 20 (8) ◽  
pp. 1144-1144 ◽  
Author(s):  
Eudocia Quant Lee ◽  
J Ricardo McFaline-Figueroa ◽  
Timothy F Cloughesy ◽  
Patrick Y Wen
Keyword(s):  
High Grade ◽  
High Grade Gliomas

The Role of Adjuvant Radiation Therapy in the Management of High-Grade Gliomas

2012 ◽  
Vol 23 (2) ◽  
pp. 247-258 ◽  
Author(s):  
Joshua J. Wind ◽  
Richard Young ◽  
Ashima Saini ◽  
Jonathan H. Sherman
Keyword(s):  
Radiation Therapy ◽  
Adjuvant Radiation ◽  
High Grade ◽  
Adjuvant Radiation Therapy ◽  
High Grade Gliomas

scholarly journals With a Little Help from My Friends: The Role of Intraoperative Fluorescent Dyes in the Surgical Management of High-Grade Gliomas

2018 ◽  
Vol 8 (2) ◽  
pp. 31 ◽  
Author(s):  
Rosario Maugeri ◽  
Alessandro Villa ◽  
Mariangela Pino ◽  
Alessia Imperato ◽  
Giuseppe Giammalva ◽  
...  
Keyword(s):  
Surgical Management ◽  
Fluorescent Dyes ◽  
High Grade ◽  
High Grade Gliomas

High-grade gliomas in children and adolescents: is there a role for reoperation?

2020 ◽  
pp. 1-10
Author(s):  
Marcos Devanir Silva da Costa ◽  
Nicole Cavalari Camargo ◽  
Patricia Alessandra Dastoli ◽  
Jardel Mendonça Nicácio ◽  
Frederico Adolfo Benevides Silva ◽  
...  
Keyword(s):  
Adjuvant Treatment ◽  
Treatment Initiation ◽  
Tumor Resection ◽  
Therapeutic Interventions ◽  
High Morbidity ◽  
High Grade ◽  
Ki 67 ◽  
Significant Difference ◽  
High Grade Gliomas

OBJECTIVETumors of the CNS are the main causes of childhood cancer and have an incidence that exceeds that of leukemia. In addition, they are the leading causes of cancer-related death in childhood. High-grade gliomas account for 11% of such neoplasms and are characterized by aggressive clinical behavior and high morbidity and mortality. There is a lack of studies focusing on the factors that can prolong survival in these patients or guide therapeutic interventions. The authors aimed to investigate the factors related to longer survival durations, with a focus on reoperation for gross-total resection (GTR).METHODSIn this retrospective cohort study, the authors analyzed 78 patients diagnosed with high-grade gliomas occurring across all CNS locations except diffuse intrinsic pontine gliomas. Patients 0 to < 19 years of age were followed up at the Pediatric Oncology Institute. Overall survival (OS) and progression-free survival (PFS) were analyzed in the context of various prognostic factors, such as age, sex, histology, extent of tumor resection, reoperation for GTR, adjuvant treatment, and treatment initiation from 2010 onward.RESULTSWith a mean age at diagnosis of 8.7 years, 50% of the patients were female and approximately 39% underwent GTR at some point, which was already achieved in approximately 46% of them in the first surgery. The median OS was 17 months, and PFS was 10 months. In terms of median OS, the authors found no significant difference between those with reoperation for GTR and patients without GTR during treatment. Significant differences were observed in the OS in terms of the extent of resection in the first surgery, age, sex, Ki-67 expression, adjuvant treatment, and treatment initiation from 2010 onward. Furthermore, the PFS values significantly differed between those with GTR in the first surgery and Ki-67 expression ≥ 50%.CONCLUSIONSThis study demonstrates the importance of GTR for these neoplasms, highlights the role of surgeons in its achievement in the first attempt, and questions the role of reoperation for this purpose. Finally, this study further supports the use of combined adjuvant treatment for the improvement of OS and PFS.

scholarly journals Spectroscopic Evaluation of Glioma Grading at 3T: The Combined Role of Short and Long TE

2012 ◽  
Vol 2012 ◽  
pp. 1-11 ◽  
Author(s):  
E. Kousi ◽  
I. Tsougos ◽  
E. Tsolaki ◽  
K. N. Fountas ◽  
K. Theodorou ◽  
...  
Keyword(s):  
Statistical Difference ◽  
Roc Analysis ◽  
Diagnostic Value ◽  
The Other ◽  
High Grade ◽  
1H Mrs ◽  
Cerebral Gliomas ◽  
High Grade Gliomas ◽  
Total Sensitivity

Purpose. To evaluate the diagnostic value of 3T1H-MRS in grading cerebral gliomas using short and long echo times.Methods. 1H-MRS was performed on 71 patients with untreated cerebral gliomas. Metabolite ratios of NAA/Cr, Cho/Cr, Cho/NAA, and mI/Cr were calculated for short and long TE and compared between low and high grade gliomas. Lipids were qualitatively evaluated. ROC analysis was performed to obtain the cut-off values for the metabolic ratios presenting statistical difference between the two glioma grades.Results. Intratumoral Cho/Cr at both TEs and long TE Cho/NAA were significantly different between low and high grade gliomas. Peritumoral NAA/Cr of both TEs, as well as long TE Cho/Cr and Cho/NAA ratios, significantly differentiated the two tumor grades. Diagnostic sensitivity of peritumoral short TE NAA/Cr proved to be superior over the other metabolic ratios, whereas intratumoral short TE Cho/Cr reached the highest levels of specificity and accuracy. Overall, short TE 1H-MRS reached higher total sensitivity in predicting glioma grade, over long TE.Conclusion. An advantage was found in using short TE over long TE 1H-MRS in the discrimination of low versus high grade gliomas. Moreover, the results suggested that the peritumoral area of gliomas may be more valuable in predicting glioma grade than using only the intratumoral area.

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