Correlation of serum and urinary matrix metalloproteases/tissue inhibitors of metalloproteases with subclinical allograft fibrosis in renal transplantation

2014 ◽  
Vol 30 (1) ◽  
pp. 1-6 ◽  
Author(s):  
Patricia Hirt-Minkowski ◽  
Hans-Peter Marti ◽  
Gideon Hönger ◽  
Denis Grandgirard ◽  
Stephen L. Leib ◽  
...  
Keyword(s):  
Renal Transplantation ◽  
Matrix Metalloproteases ◽  
Tissue Inhibitors ◽  
Tissue Inhibitors Of Metalloproteases

scholarly journals Do Matrix Metalloproteases and Tissue Inhibitors of Metalloproteases in Tenocytes of the Rotator Cuff Differ with Varying Donor Characteristics?

2015 ◽  
Vol 16 (12) ◽  
pp. 13141-13157 ◽  
Author(s):  
Franka Klatte-Schulz ◽  
Thomas Aleyt ◽  
Stephan Pauly ◽  
Sven Geißler ◽  
Christian Gerhardt ◽  
...  
Keyword(s):  
Rotator Cuff ◽  
Matrix Metalloproteases ◽  
Tissue Inhibitors ◽  
Donor Characteristics ◽  
Tissue Inhibitors Of Metalloproteases

scholarly journals Matrix metalloproteases and their tissue inhibitors in non-alcoholic liver fibrosis of human immunodeficiency virus-infected patients

2017 ◽  
Vol 6 (2) ◽  
pp. 36 ◽  
Author(s):  
Julio Collazos ◽  
Eulalia Valle-Garay ◽  
Tomás Suárez-Zarracina ◽  
Angel-Hugo Montes ◽  
José A Cartón ◽  
...  
Keyword(s):  
Human Immunodeficiency Virus ◽  
Liver Fibrosis ◽  
Matrix Metalloproteases ◽  
Tissue Inhibitors ◽  
Immunodeficiency Virus

scholarly journals MMP-14 is necessary but not sufficient for invasion of three-dimensional collagen by human muscle satellite cells

2014 ◽  
Vol 307 (2) ◽  
pp. C140-C149 ◽  
Author(s):  
Dane K. Lund ◽  
Vincent Mouly ◽  
DDW Cornelison
Keyword(s):  
Satellite Cells ◽  
Three Dimensional ◽  
Collagen Matrix ◽  
Human Muscle ◽  
Matrix Metalloproteases ◽  
Collagen I ◽  
Muscle Satellite Cells ◽  
Mediate Cell ◽  
Human And Mouse ◽  
Tissue Inhibitors Of Metalloproteases

The twenty-five known matrix metalloproteases (MMPs) and their endogenous inhibitors, tissue inhibitors of metalloproteases (TIMPs), mediate cell invasion through the extracellular matrix (ECM). In a comparative three-dimensional assay, we analyzed human and mouse satellite cells' competence to invade an artificial ECM (collagen I). We identified a single MMP that 1) is expressed by human muscle satellite cells; 2) is induced at the mRNA/protein level by adhesion to collagen I; and 3) is necessary for invasion into a collagen I matrix. Interestingly, murine satellite cells neither express this MMP, nor invade the collagen matrix. However, exogenous human MMP-14 is not sufficient to induce invasion of a collagen matrix by murine cells, emphasizing species differences.

scholarly journals Tissue inhibitors of metalloproteases strike a nerve

2018 ◽  
Vol 13 (11) ◽  
pp. 1890 ◽  
Author(s):  
VeronicaI Shubayev ◽  
AlexY Strongin
Keyword(s):  
Tissue Inhibitors ◽  
Tissue Inhibitors Of Metalloproteases

Role of Tissue Inhibitors of Matrix Metalloproteases-1 (TIMP-1) in Evolution of CCl4-Induced Liver Cirrhosis in Mice.

2017 ◽  
Vol 21 (2) ◽  
pp. 141-146
Author(s):  
Eman Abu-Dief ◽  
Doha Mohammed ◽  
Sherine Mohammed ◽  
Nesreen Abd El-Haliem ◽  
Ashraf El-Badry
Keyword(s):  
Liver Cirrhosis ◽  
Matrix Metalloproteases ◽  
Tissue Inhibitors

Effect of the Expression of Matrix Metalloproteases and Their Tissue Inhibitors on Survival of Patients with Resectable Colorectal Cancer

2012 ◽  
Vol 57 (8) ◽  
pp. 2063-2071 ◽  
Author(s):  
Lucía González ◽  
Noemí Eiró ◽  
Luis O. González ◽  
Alejandro Andicoechea ◽  
Esther Barbón ◽  
...  
Keyword(s):  
Colorectal Cancer ◽  
Matrix Metalloproteases ◽  
Tissue Inhibitors

scholarly journals Modulation of the Extracellular Signal-Regulated Protein Kinase and Tissue Inhibitors of Matrix Metalloproteases-1 Gene in Chronic Neuropathic Pain

2021 ◽  
Vol 27 ◽  
pp. 251-256
Author(s):  
Ashok Kumar Saxena ◽  
Deepanshu Khrolia ◽  
Geetanjali T Chilkoti ◽  
Prakash Gyandev Gondode ◽  
Tusha Sharma ◽  
...  
Keyword(s):  
Chronic Pain ◽  
Neuropathic Pain ◽  
Protein Kinase ◽  
Mrna Expression ◽  
Quantitative Polymerase Chain Reaction ◽  
Matrix Metalloproteases ◽  
Pain Clinic ◽  
Tissue Inhibitors ◽  
Extracellular Signal ◽  
Timp1 Gene

Objectives: The aim of this study is to study the modulation of extracellular signal-regulated protein kinase (ERK) and tissue inhibitors of matrix metalloproteases 1 (TIMP 1) gene in patients with neuropathic pain (NP). Materials and Methods: In the present, cross-sectional, observational study, 2 ml of venous baseline sample was withdrawn from all the patients with neuropathic (NP) or non NP (NNP) soon after their diagnosis or on their first visit to the pain clinic. A real-time quantitative polymerase chain reaction experiment was conducted to measure the mRNA expression of TIMP1 and ERK genes in blood samples. The Delta Ct, Delta Ct, and fold change analysis of both the genes were conducted between patients with NP and NNP. Results: A total of 285 patients with chronic pain were assessed, out of which, 153 patients had NP and 132 had NNP. The average duration of chronic pain was 11 months for 285 patients. The mRNA expression of TIMP1 gene is significantly down regulated (2.65-fold) (P (-f. 01), and the mRNA expression level of ERK is significantly up regulated (2.03-fold) (P (-f. 01) in NP patients when compared with NNP. Conclusion: The mRNA expression of TIMP1 gene is significantly down regulated, and ERK is significantly up regulated in patients with NP. Further, multicentric trials with larger sample size are recommended to confirm this finding.

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