scholarly journals Do Matrix Metalloproteases and Tissue Inhibitors of Metalloproteases in Tenocytes of the Rotator Cuff Differ with Varying Donor Characteristics?

2015 ◽  
Vol 16 (12) ◽  
pp. 13141-13157 ◽  
Author(s):  
Franka Klatte-Schulz ◽  
Thomas Aleyt ◽  
Stephan Pauly ◽  
Sven Geißler ◽  
Christian Gerhardt ◽  
...  
Keyword(s):  
Rotator Cuff ◽  
Matrix Metalloproteases ◽  
Tissue Inhibitors ◽  
Donor Characteristics ◽  
Tissue Inhibitors Of Metalloproteases

Correlation of serum and urinary matrix metalloproteases/tissue inhibitors of metalloproteases with subclinical allograft fibrosis in renal transplantation

2014 ◽  
Vol 30 (1) ◽  
pp. 1-6 ◽  
Author(s):  
Patricia Hirt-Minkowski ◽  
Hans-Peter Marti ◽  
Gideon Hönger ◽  
Denis Grandgirard ◽  
Stephen L. Leib ◽  
...  
Keyword(s):  
Renal Transplantation ◽  
Matrix Metalloproteases ◽  
Tissue Inhibitors ◽  
Tissue Inhibitors Of Metalloproteases

scholarly journals Matrix metalloproteases and their tissue inhibitors in non-alcoholic liver fibrosis of human immunodeficiency virus-infected patients

2017 ◽  
Vol 6 (2) ◽  
pp. 36 ◽  
Author(s):  
Julio Collazos ◽  
Eulalia Valle-Garay ◽  
Tomás Suárez-Zarracina ◽  
Angel-Hugo Montes ◽  
José A Cartón ◽  
...  
Keyword(s):  
Human Immunodeficiency Virus ◽  
Liver Fibrosis ◽  
Matrix Metalloproteases ◽  
Tissue Inhibitors ◽  
Immunodeficiency Virus

scholarly journals MMP-14 is necessary but not sufficient for invasion of three-dimensional collagen by human muscle satellite cells

2014 ◽  
Vol 307 (2) ◽  
pp. C140-C149 ◽  
Author(s):  
Dane K. Lund ◽  
Vincent Mouly ◽  
DDW Cornelison
Keyword(s):  
Satellite Cells ◽  
Three Dimensional ◽  
Collagen Matrix ◽  
Human Muscle ◽  
Matrix Metalloproteases ◽  
Collagen I ◽  
Muscle Satellite Cells ◽  
Mediate Cell ◽  
Human And Mouse ◽  
Tissue Inhibitors Of Metalloproteases

The twenty-five known matrix metalloproteases (MMPs) and their endogenous inhibitors, tissue inhibitors of metalloproteases (TIMPs), mediate cell invasion through the extracellular matrix (ECM). In a comparative three-dimensional assay, we analyzed human and mouse satellite cells' competence to invade an artificial ECM (collagen I). We identified a single MMP that 1) is expressed by human muscle satellite cells; 2) is induced at the mRNA/protein level by adhesion to collagen I; and 3) is necessary for invasion into a collagen I matrix. Interestingly, murine satellite cells neither express this MMP, nor invade the collagen matrix. However, exogenous human MMP-14 is not sufficient to induce invasion of a collagen matrix by murine cells, emphasizing species differences.

scholarly journals Matrix Metalloproteases 1 and 3 Promoter Gene Polymorphism Is Associated With Rotator Cuff Tear

2017 ◽  
Vol 475 (7) ◽  
pp. 1904-1910 ◽  
Author(s):  
Jorge H. Assunção ◽  
Alexandre L. Godoy-Santos ◽  
Maria Cristina L. G. dos Santos ◽  
Eduardo A. Malavolta ◽  
Mauro E. C. Gracitelli ◽  
...  
Keyword(s):  
Rotator Cuff ◽  
Gene Polymorphism ◽  
Rotator Cuff Tear ◽  
Matrix Metalloproteases ◽  
Cuff Tear ◽  
Promoter Gene

scholarly journals Role of matrix metalloproteases 1/3 gene polymorphisms in patients with rotator cuff tear

2019 ◽  
Vol 39 (10) ◽  
Author(s):  
Kaisong Miao ◽  
Lifeng Jiang ◽  
Xindie Zhou ◽  
Lidong Wu ◽  
Yong Huang ◽  
...  
Keyword(s):  
Rotator Cuff ◽  
Rotator Cuff Tear ◽  
Fragment Length Polymorphism ◽  
Direct Sequencing ◽  
Matrix Metalloproteases ◽  
Chain Reaction ◽  
Cuff Tear ◽  
Increased Risk ◽  
Polymerase Chain

Abstract An association of Matrix Metalloproteinases-1/3 (MMP-1/3) rs1799750/rs3025058 polymorphism with increased risk of rotator cuff tear (RCT) has been reported in a Brazilian population. However, this significant association has not been confirmed in the Chinese population. Genotyping was conducted by polymerase chain reaction (PCR)-restriction fragment length polymorphism and direct sequencing. Our results demonstrated that individuals with the TT genotype had a significantly higher risk of RCT compared with those with the CC genotype. The increased risk of RCT progression was associated with the 2G allele of the rs1799750 polymorphism. No significant association was observed for genotypic and allelic frequencies of the rs3025058 polymorphism. A significant association of the MMP-1 rs1799750 polymorphism was observed with smokers, drinkers and people aged ≥60 years and non-diabetic people. Additionally, the MMP-1 rs1799750 polymorphism was associated with pre-operative stiffness in RCT patients. In conclusion, a significant correlation was identified between the MMP-1 rs1799750 polymorphism and RCT. The MMP-1 rs1799750 polymorphism might be considered as a biomarker of genetically high-risk RCT, helping to clarify the mechanism of RCT.

scholarly journals Tissue inhibitors of metalloproteases strike a nerve

2018 ◽  
Vol 13 (11) ◽  
pp. 1890 ◽  
Author(s):  
VeronicaI Shubayev ◽  
AlexY Strongin
Keyword(s):  
Tissue Inhibitors ◽  
Tissue Inhibitors Of Metalloproteases

Role of Tissue Inhibitors of Matrix Metalloproteases-1 (TIMP-1) in Evolution of CCl4-Induced Liver Cirrhosis in Mice.

2017 ◽  
Vol 21 (2) ◽  
pp. 141-146
Author(s):  
Eman Abu-Dief ◽  
Doha Mohammed ◽  
Sherine Mohammed ◽  
Nesreen Abd El-Haliem ◽  
Ashraf El-Badry
Keyword(s):  
Liver Cirrhosis ◽  
Matrix Metalloproteases ◽  
Tissue Inhibitors
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