Survival benefit of chemotherapy in a contemporary cohort of metastatic urachal carcinoma

2021 ◽  
Author(s):  
Rocco Simone Flammia ◽  
Francesco Chierigo ◽  
Christoph Würnschimmel ◽  
Benedikt Horlemann ◽  
Benedikt Hoeh ◽  
...  
Keyword(s):  
Survival Benefit ◽  
Urachal Carcinoma

309: Surgery of Urachal Carcinoma – Evaluation of Long Term Outcome

2004 ◽  
Vol 171 (4S) ◽  
pp. 81-81
Author(s):  
Michael Cohen ◽  
Bernard H. Bochner ◽  
Harry W. Herr
Keyword(s):  
Term Outcome ◽  
Urachal Carcinoma ◽  
Long Term Outcome

Survival benefit of the Ross procedure in young adults: A retrospective single-center analysis over 15 years

2013 ◽  
Vol 61 (S 01) ◽  
Author(s):  
M Andreas ◽  
D Wiedemann ◽  
G Seebacher ◽  
E Reida ◽  
R Rosenhek ◽  
...  
Keyword(s):  
Young Adults ◽  
Survival Benefit ◽  
Ross Procedure ◽  
Single Center

Sinonasal Squamous Cell Carcinoma Outcomes: Does Treatment at a High-Volume Center Confer Survival Benefit?

2020 ◽  
Author(s):  
Jordan I. Teitelbaum ◽  
Ian Barak ◽  
Khalil Issa ◽  
Feras Ackall ◽  
Sin-Ho Jung ◽  
...  
Keyword(s):  
Squamous Cell Carcinoma ◽  
Cell Carcinoma ◽  
Squamous Cell ◽  
Survival Benefit ◽  
High Volume ◽  
High Volume Center

Subjective Fear Dilutes as Group Size Increases

2020 ◽  
Author(s):  
dean mobbs ◽  
Ellen Tedeschi ◽  
Anastasia Buyalskaya ◽  
Brian Silston
Keyword(s):  
Group Size ◽  
Real World ◽  
Survival Benefit ◽  
Group Living ◽  
External Factors ◽  
Threat Perception ◽  
Perception Of Threat ◽  
Threat Level ◽  
Internal States ◽  
Risk Dilution

According to Hamilton’s Selfish Herd Theory, a crucial survival benefit of group living is that it provides a ‘risk dilution’ function against predation. Despite a large literature on group living benefits in animals, few studies have been conducted on how group size alters subjective fear or threat perception in humans, and on what factors drive preferences for being in groups when facing threats. We conducted seven experiments (N=3,838) to test (A) if the presence of others decreases perception of threat under a variety of conditions. In studies 1 to 3, we experimentally manipulated group size in hypothetical and real-world situations, to show that fear responses decreased as group size increased. In studies 4 to 7 we again used a combination of hypothetical, virtual and real-world decisions to test (B) how internal states (e.g. anxiety) and external factors (e.g. threat level, availability of help) affected participants’ preference for groups. Participants consistently chose larger groups when threat and anxiety were high. Overall, our findings show that group size provides a salient signal of protection and safety.

Proliferation-dominant high-grade astrocytoma: survival benefit associated with extensive resection of FLAIR abnormality region

2020 ◽  
Vol 132 (4) ◽  
pp. 998-1005 ◽  
Author(s):  
Haihui Jiang ◽  
Yong Cui ◽  
Xiang Liu ◽  
Xiaohui Ren ◽  
Mingxiao Li ◽  
...  
Keyword(s):  
Survival Benefit ◽  
Proportional Hazards ◽  
Proportional Hazards Model ◽  
Characteristic Curve ◽  
Extent Of Resection ◽  
Cox Proportional Hazards ◽  
Cox Proportional Hazards Model ◽  
High Grade ◽  
Extensive Resection ◽  
High Grade Astrocytoma

OBJECTIVEThe aim of this study was to investigate the relationship between extent of resection (EOR) and survival in terms of clinical, molecular, and radiological factors in high-grade astrocytoma (HGA).METHODSClinical and radiological data from 585 cases of molecularly defined HGA were reviewed. In each case, the EOR was evaluated twice: once according to contrast-enhanced T1-weighted images (CE-T1WI) and once according to fluid attenuated inversion recovery (FLAIR) images. The ratio of the volume of the region of abnormality in CE-T1WI to that in FLAIR images (VFLAIR/VCE-T1WI) was calculated and a receiver operating characteristic curve was used to determine the optimal cutoff value for that ratio. Univariate and multivariate analyses were performed to identify the prognostic value of each factor.RESULTSBoth the EOR evaluated from CE-T1WI and the EOR evaluated from FLAIR could divide the whole cohort into 4 subgroups with different survival outcomes (p < 0.001). Cases were stratified into 2 subtypes based on VFLAIR/VCE-T1WIwith a cutoff of 10: a proliferation-dominant subtype and a diffusion-dominant subtype. Kaplan-Meier analysis showed a significant survival advantage for the proliferation-dominant subtype (p < 0.0001). The prognostic implication has been further confirmed in the Cox proportional hazards model (HR 1.105, 95% CI 1.078–1.134, p < 0.0001). The survival of patients with proliferation-dominant HGA was significantly prolonged in association with extensive resection of the FLAIR abnormality region beyond contrast-enhancing tumor (p = 0.03), while no survival benefit was observed in association with the extensive resection in the diffusion-dominant subtype (p=0.86).CONCLUSIONSVFLAIR/VCE-T1WIis an important classifier that could divide the HGA into 2 subtypes with distinct invasive features. Patients with proliferation-dominant HGA can benefit from extensive resection of the FLAIR abnormality region, which provides the theoretical basis for a personalized resection strategy.

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