Identification of in vivo interaction between Hepatitis C Virus core protein and 5′ and 3′ UTR RNA

2009 ◽  
Vol 145 (2) ◽  
pp. 285-292 ◽  
Author(s):  
Kyung Lee Yu ◽  
Soo In Jang ◽  
Ji Chang You
Keyword(s):  
Hepatitis C Virus ◽  
Hepatitis C ◽  
Core Protein ◽  
Virus Core

scholarly journals Hepatitis C Virus Core Protein Interacts with 14-3-3 Protein and Activates the Kinase Raf-1

2000 ◽  
Vol 74 (4) ◽  
pp. 1736-1741 ◽  
Author(s):  
Hiroshi Aoki ◽  
Junpei Hayashi ◽  
Mitsuhiko Moriyama ◽  
Yasuyuki Arakawa ◽  
Okio Hino
Keyword(s):  
Hepatitis C Virus ◽  
Hepatitis C ◽  
Growth Regulation ◽  
Core Protein ◽  
Dependent Manner ◽  
Kinase Activation ◽  
Virus Core ◽  
Hcv Core Protein

ABSTRACT Persistent hepatitis C virus (HCV) infection is a major cause of chronic liver dysfunction in humans and is epidemiologically closely associated with the development of human hepatocellular carcinoma. Among HCV components, core protein has been reported to be implicated in cell growth regulation both in vitro and in vivo, although mechanisms explaining those effects are still unclear. In the present study, we identified that members of the 14-3-3 protein family associate with HCV core protein. 14-3-3 protein bound to HCV core protein in a phosphoserine-dependent manner. Introduction of HCV core protein caused a substantial increase in Raf-1 kinase activity in HepG2 cells and in a yeast genetic assay. Furthermore, the HCV core–14-3-3 interaction was essential for Raf-1 kinase activation by HCV core protein. These results suggest that HCV core protein may represent a novel type of Raf-1 kinase-activating protein through its interaction with 14-3-3 protein and may contribute to hepatocyte growth regulation.

Hepatitis B viral polymerase fusion proteins are biologically active and can interact with the hepatitis C virus core protein in vivo

2001 ◽  
Vol 8 (6) ◽  
pp. 492-503 ◽  
Author(s):  
Kun-Lin Chen ◽  
Chun-Ming Chen ◽  
Chwen-Ming Shih ◽  
Huey-Lan Huang ◽  
Yan-Hwa Wu Lee ◽  
...  
Keyword(s):  
Hepatitis C Virus ◽  
Hepatitis C ◽  
Hepatitis B ◽  
Fusion Proteins ◽  
Core Protein ◽  
Biologically Active ◽  
Viral Polymerase ◽  
Virus Core

Biosynthesis and biochemical properties of the hepatitis C virus core protein.

1994 ◽  
Vol 68 (6) ◽  
pp. 3631-3641 ◽  
Author(s):  
E Santolini ◽  
G Migliaccio ◽  
N La Monica
Keyword(s):  
Hepatitis C Virus ◽  
Hepatitis C ◽  
Core Protein ◽  
Biochemical Properties ◽  
Virus Core

Truncated hepatitis C virus core protein encoded in hepatocellular carcinomas

2004 ◽  
Author(s):  
Rin Yamaguchi ◽  
Seiya Momosaki ◽  
Guang Gao ◽  
Chu Hsia ◽  
Masamichi Kojiro ◽  
...  
Keyword(s):  
Hepatitis C Virus ◽  
Hepatitis C ◽  
Core Protein ◽  
Virus Core ◽  
Hepatocellular Carcinomas

Genetic control of the murine humoral response to distinct epitopes of hepatitis C virus core protein

1995 ◽  
Vol 2 (1) ◽  
pp. 9-17 ◽  
Author(s):  
Z. Chen ◽  
I. Berkower ◽  
R. Y.-H. Wang ◽  
W.-M. Ching ◽  
H. J. Alter ◽  
...  
Keyword(s):  
Hepatitis C Virus ◽  
Hepatitis C ◽  
Genetic Control ◽  
Core Protein ◽  
Humoral Response ◽  
Virus Core

Titration of antibody against hepatitis C virus core protein and its clinical utility

1993 ◽  
Vol 18 (1) ◽  
pp. 138-139 ◽  
Author(s):  
Yuko Taura ◽  
Shigetoshi Fujiyama ◽  
Shin-ichi Kawano ◽  
Shinjiro Sato ◽  
Masafumi Goto ◽  
...  
Keyword(s):  
Hepatitis C Virus ◽  
Hepatitis C ◽  
Clinical Utility ◽  
Core Protein ◽  
Virus Core
Sign in / Sign up

Export Citation Format

Share Document