Effects of selective estrogen receptor modulators on allocentric working memory performance and on dendritic spines in medial prefrontal cortex pyramidal neurons of ovariectomized rats

2012 ◽  
Vol 61 (4) ◽  
pp. 512-517 ◽  
Author(s):  
D.A. Velázquez-Zamora ◽  
L.M. Garcia-Segura ◽  
I. González-Burgos
Keyword(s):  
Working Memory ◽  
Estrogen Receptor ◽  
Prefrontal Cortex ◽  
Medial Prefrontal Cortex ◽  
Dendritic Spines ◽  
Pyramidal Neurons ◽  
Memory Performance ◽  
Ovariectomized Rats ◽  
Estrogen Receptor Modulators ◽  
Receptor Modulators

scholarly journals Selective Estrogen Receptor Modulators Regulate Dendritic Spine Plasticity in the Hippocampus of Male Rats

2012 ◽  
Vol 2012 ◽  
pp. 1-6 ◽  
Author(s):  
Ignacio González-Burgos ◽  
Martha C. Rivera-Cervantes ◽  
Dulce A. Velázquez-Zamora ◽  
Alfredo Feria-Velasco ◽  
Luis Miguel Garcia-Segura
Keyword(s):  
Estrogen Receptor ◽  
Dendritic Spines ◽  
Pyramidal Neurons ◽  
Selective Estrogen Receptor Modulators ◽  
Brain Inflammation ◽  
Male Rats ◽  
Numerical Density ◽  
Ca1 Pyramidal Neurons ◽  
Estrogen Receptor Modulators ◽  
Receptor Modulators

Some selective estrogen receptor modulators, such as raloxifene and tamoxifen, are neuroprotective and reduce brain inflammation in several experimental models of neurodegeneration. In addition, raloxifene and tamoxifen counteract cognitive deficits caused by gonadal hormone deprivation in male rats. In this study, we have explored whether raloxifene and tamoxifen may regulate the number and geometry of dendritic spines in CA1 pyramidal neurons of the rat hippocampus. Young adult male rats were injected with raloxifene (1 mg/kg), tamoxifen (1 mg/kg), or vehicle and killed 24 h after the injection. Animals treated with raloxifene or tamoxifen showed an increased numerical density of dendritic spines in CA1 pyramidal neurons compared to animals treated with vehicle. Raloxifene and tamoxifen had also specific effects in the morphology of spines. These findings suggest that raloxifene and tamoxifen may influence the processing of information by hippocampal pyramidal neurons by affecting the number and shape of dendritic spines.

Epidural Direct Current Stimulation Over the Left Medial Prefrontal Cortex Facilitates Spatial Working Memory Performance in Rats

2013 ◽  
Vol 6 (3) ◽  
pp. 261-269 ◽  
Author(s):  
Juliana Cardoso de Souza Custódio ◽  
Cleciane Waldetário Martins ◽  
Marcelo Di Marcello Valladão Lugon ◽  
Felipe Fregni ◽  
Ester Miyuki Nakamura-Palacios
Keyword(s):  
Working Memory ◽  
Prefrontal Cortex ◽  
Medial Prefrontal Cortex ◽  
Direct Current ◽  
Spatial Working Memory ◽  
Memory Performance ◽  
Direct Current Stimulation
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