The differential effects of body fat distribution on insulin and glucose metabolism during pregnancy

1994 ◽  
Vol 171 (4) ◽  
pp. 875-884 ◽  
Author(s):  
Mark B. Landon ◽  
Kwame Osei ◽  
Maureen Platt ◽  
Thomas O'Dorisio ◽  
Philip Samuels ◽  
...  
Keyword(s):  
Glucose Metabolism ◽  
Body Fat ◽  
Fat Distribution ◽  
Body Fat Distribution ◽  
Differential Effects

scholarly journals Dietary glycemic index and load, measures of glucose metabolism, and body fat distribution in older adults

2005 ◽  
Vol 82 (3) ◽  
pp. 547-552 ◽  
Author(s):  
Nadine R Sahyoun ◽  
Amy L Anderson ◽  
Alka M Kanaya ◽  
Pauline Koh-Banerjee ◽  
Stephen B Kritchevsky ◽  
...  
Keyword(s):  
Older Adults ◽  
Glucose Metabolism ◽  
Body Fat ◽  
Glycemic Index ◽  
Fat Distribution ◽  
Body Fat Distribution ◽  
Dietary Glycemic Index

A rosiglitazone-induced increase in adiponectin does not improve glucose metabolism in HIV-infected patients with overt lipoatrophy

2009 ◽  
Vol 297 (5) ◽  
pp. E1097-E1104 ◽  
Author(s):  
Regje M. E. Blümer ◽  
Marc van der Valk ◽  
Mariette Ackermans ◽  
Erik Endert ◽  
Mireille J. Serlie ◽  
...  
Keyword(s):  
Glucose Metabolism ◽  
Body Fat ◽  
Statistical Power ◽  
Controlled Trial ◽  
Glucose Production ◽  
Fat Distribution ◽  
Body Fat Distribution ◽  
Glucose Disposal ◽  
Total Adiponectin ◽  
Hiv Lipodystrophy

HIV-infected patients on antiretroviral therapy frequently develop changes in body fat distribution and disturbances in glucose metabolism, associated with reduced adiponectin levels. Because adiponectin, principally the high-molecular-weight (HMW) form, has insulin-sensitizing properties, we investigated the effects of an increase in adiponectin on glucose metabolism in HIV-lipodystrophy. In this randomized, double-blind, placebo-controlled trial, we included HIV-1-infected patients with severe lipoatrophy, with an undetectable viral load and who had received neither protease inhibitors nor stavudine for ≥6 mo. Patients were randomized to rosiglitazone [8 mg daily ( n = 8)] to increase adiponectin levels or placebo ( n = 5) for 16 wk. Peripheral glucose disposal, glucose production, and lipolysis were measured after an overnight fast and during a hyperinsulinemic-euglycemic clamp using stable isotopes. Body composition was assessed by computed tomography and dual-energy X-ray absorptiometry. Although body fat distribution was unaffected, rosiglitazone increased total plasma adiponectin levels by 107% ( P < 0.02) and the ratio of HMW to total adiponectin by 73% ( P < 0.001). In the placebo group, neither total adiponectin levels ( P = 0.62) nor the ratio of HMW to total adiponectin changed ( P = 0.94). The marked increase in adiponectin induced by rosiglitazone was not associated with significant changes in basal endogenous glucose production ( P = 0.90), basal lipolysis ( P = 0.90), insulin-mediated suppression of glucose production ( P = 0.17) and lipolysis ( P = 0.54) nor with changes in peripheral glucose disposal ( P = 0.13). Acknowledging the limited statistical power of our small study, these findings, if confirmed by larger studies, could question the importance of adiponectin in regulating glucose metabolism in HIV-lipodystrophy.

Glucose Metabolism in Obesity: Influence of Body Fat Distribution*

1988 ◽  
Vol 67 (4) ◽  
pp. 760-767 ◽  
Author(s):  
ALAN N. PEIRIS ◽  
MARK F. STRUVE ◽  
ROBERT A. MUELLER ◽  
MARTHA B. LEE ◽  
AHMED H. KISSEBAH
Keyword(s):  
Glucose Metabolism ◽  
Body Fat ◽  
Fat Distribution ◽  
Body Fat Distribution

scholarly journals Body Fat Distribution, Glucose Metabolism, and Diabetes Status among Older Adults: The Multiethnic Cohort Adiposity Phenotype Study

2021 ◽  
Author(s):  
Gertraud Maskarinec ◽  
Phyllis Raquinio ◽  
Bruce S. Kristal ◽  
Adrian A. Franke ◽  
Steven D. Buchthal ◽  
...  
Keyword(s):  
Older Adults ◽  
Glucose Metabolism ◽  
Body Fat ◽  
Fat Distribution ◽  
Body Fat Distribution ◽  
Multiethnic Cohort ◽  
Diabetes Status

scholarly journals Dietary glycemic index and load, measures of glucose metabolism, and body fat distribution in older adults

2005 ◽  
Vol 82 (3) ◽  
pp. 547-552 ◽  
Author(s):  
Nadine R Sahyoun ◽  
Amy L Anderson ◽  
Alka M Kanaya ◽  
Pauline Koh-Banerjee ◽  
Stephen B Kritchevsky ◽  
...  
Keyword(s):  
Older Adults ◽  
Glucose Metabolism ◽  
Body Fat ◽  
Glycemic Index ◽  
Fat Distribution ◽  
Body Fat Distribution ◽  
Dietary Glycemic Index

Body Fat Distribution and Body Composition During GnRH Agonist Therapy

2001 ◽  
Vol 97 (3) ◽  
pp. 338-342 ◽  
Author(s):  
HIDEKI YAMASAKI ◽  
TSUTOMU DOUCHI ◽  
SHINAKO YAMAMOTO ◽  
TOSHIMICHI OKI ◽  
RIKI KUWAHATA ◽  
...  
Keyword(s):  
Body Composition ◽  
Body Fat ◽  
Gnrh Agonist ◽  
Fat Distribution ◽  
Body Fat Distribution ◽  
Agonist Therapy
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