Post-ischemic hypothermia blocks caspase-3 activation in the newborn rat brain after hypoxia–ischemia

2001 ◽  
Vol 910 (1-2) ◽  
pp. 187-191 ◽  
Author(s):  
Hirotsugu Fukuda ◽  
Takuji Tomimatsu ◽  
Noriyoshi Watanabe ◽  
Jun Wu Mu ◽  
Masatomo Kohzuki ◽  
...  
Keyword(s):  
Rat Brain ◽  
Caspase 3 ◽  
Newborn Rat ◽  
Hypoxia Ischemia

Postischemic Hyperthermia Induced Caspase-3 Activation in the Newborn Rat Brain after Hypoxia-Ischemia and Exacerbated the Brain Damage

Neonatology ◽  
2003 ◽  
Vol 84 (2) ◽  
pp. 164-171 ◽  
Author(s):  
Hirotsugu Fukuda ◽  
Takuji Tomimatsu ◽  
Takeshi Kanagawa ◽  
Junwu Mu ◽  
Masatomo Kohzuki ◽  
...  
Keyword(s):  
Rat Brain ◽  
Brain Damage ◽  
Caspase 3 ◽  
Newborn Rat ◽  
Hypoxia Ischemia ◽  
The Brain

Sequence of neuronal responses assessed by immunohistochemistry in the newborn rat brain after hypoxia-ischemia

1997 ◽  
Vol 177 (3) ◽  
pp. 519-526 ◽  
Author(s):  
Arturo Ota ◽  
Tomoaki Ikeda ◽  
Tsuyomu Ikenoue ◽  
Kiyotaka Toshimori
Keyword(s):  
Rat Brain ◽  
Neuronal Responses ◽  
Newborn Rat ◽  
Hypoxia Ischemia

Hypoxia-Ischemia, but Not Hypoxia Alone, Induces the Expression of Heme Oxygenase-1 (HSP32) in Newborn Rat Brain

1997 ◽  
Vol 17 (6) ◽  
pp. 647-658 ◽  
Author(s):  
Marcelle Bergeron ◽  
Donna M. Ferriero ◽  
Hendrik J. Vreman ◽  
David K. Stevenson ◽  
Frank R. Sharp
Keyword(s):  
Rat Brain ◽  
Heme Oxygenase ◽  
Heme Oxygenase 1 ◽  
Bile Pigments ◽  
Newborn Rat ◽  
Brain Macrophages ◽  
Rat Pups ◽  
Hypoxia Ischemia ◽  
Wistar Kyoto ◽  
The Brain

Heme oxygenase (HO) is the rate-limiting enzyme in the degradation of heme to produce bile pigments and carbon monoxide. The HO-1 isozyme is induced by a variety of agents such as heat, heme, and hydrogen peroxide. Evidence suggests that the bile pigments serve as antioxidants in cells with compromised defense mechanisms. Because hypoxia-ischemia (HI) increases the level of oxygen free radicals, the induction of HO-1 expression in the brain during ischemia could modulate the response to oxidative stress. To study the possible involvement of HO-1 in neonatal hypoxia-induced ischemic tolerance, we examined the brains of newborn rat pups exposed to 8% O2 (for 2.5 to 3 hours), and the brain of chronically hypoxic rat pups with congenital cardiac defects (Wistar Kyoto; WKY/ NCr). Heme oxygenase-1 immunostaining did not change after either acute or chronic hypoxia, suggesting that HO-1 is not a good candidate for explaining hypoxia preconditioning in newborn rat brain. To study the role of HO-1 in neonatal HI, 1-week-old rats were subjected to right carotid coagulation and exposure to 8% O2/92% N2 for 2.5 hours. Whereas HO enzymatic activity was unchanged in ipsilateral cortex and subcortical regions compared with the contralateral hemisphere or control brains, immunocytochemistry and Western blot analysis showed increased HO-1 staining in ipsilateral cortex, hippocampus, and striatum at 12 to 24 hours up to 7 days after HI. Double fluorescence immunostaining showed that HO-1 was expressed mostly in ED-1 positive macrophages. Because activated brain macrophages have been associated with the release of several cytotoxic molecules, the presence of HO-1 positive brain macrophages may determine the tissue vulnerability after HI injury.

Simvastatin reduces caspase-3 activation and inflammatory markers induced by hypoxia–ischemia in the newborn rat

2006 ◽  
Vol 21 (1) ◽  
pp. 119-126 ◽  
Author(s):  
Silvia Carloni ◽  
Erika Mazzoni ◽  
Mauro Cimino ◽  
Maria Grazia De Simoni ◽  
Carlo Perego ◽  
...  
Keyword(s):  
Inflammatory Markers ◽  
Caspase 3 ◽  
Newborn Rat ◽  
Hypoxia Ischemia

Resveratrol ameliorates hypoxia/ischemia-induced behavioral deficits and brain injury in the neonatal rat brain

2011 ◽  
Vol 1425 ◽  
pp. 98-110 ◽  
Author(s):  
Filippos Karalis ◽  
Vassiliki Soubasi ◽  
Thomas Georgiou ◽  
Christos T. Nakas ◽  
Constantina Simeonidou ◽  
...  
Keyword(s):  
Brain Injury ◽  
Rat Brain ◽  
Neonatal Rat ◽  
Behavioral Deficits ◽  
Hypoxia Ischemia ◽  
Neonatal Rat Brain

scholarly journals Hypoxia-ischemia induces thioredoxin expression and nitrotyrosine formation in new-born rat brain

Redox Report ◽  
2002 ◽  
Vol 7 (5) ◽  
pp. 256-259 ◽  
Author(s):  
Itaro Hattori ◽  
Yasushi Takagi ◽  
Kazuhiko Nozaki ◽  
Norihiko Kondo ◽  
Jie Bai ◽  
...  
Keyword(s):  
Rat Brain ◽  
New Born ◽  
Hypoxia Ischemia
Sign in / Sign up

Export Citation Format

Share Document