Contribution of stromal and epithelial cells to cyclooxygenase-2 (COX-2) activity in Barrett's esophagus

2001 ◽  
Vol 120 (5) ◽  
pp. A78-A79
Author(s):  
N BUTTAR ◽  
K WANG ◽  
M ANDERSON ◽  
L LUTZKE ◽  
K KRISHNADATH
Keyword(s):  
Epithelial Cells ◽  
Barrett’S Esophagus ◽  
Barrett's Esophagus ◽  
Cyclooxygenase 2 ◽  
Cox 2

Contribution of stromal and epithelial cells to cyclooxygenase-2 (COX-2) activity in Barrett's esophagus

2001 ◽  
Vol 120 (5) ◽  
pp. A78-A79
Author(s):  
Navtej S. Buttar ◽  
Kenneth K. Wang ◽  
Marlys A. Anderson ◽  
Lori S. Lutzke ◽  
Kausilia K Krishnadath
Keyword(s):  
Epithelial Cells ◽  
Barrett’S Esophagus ◽  
Barrett's Esophagus ◽  
Cyclooxygenase 2 ◽  
Cox 2

Cyclooxygenase-2 (COX-2) mediated anti-apoptosis may occur via Bcl-2 in the progression of Barrett's esophagus to adenocarcinoma

2004 ◽  
Vol 22 (14_suppl) ◽  
pp. 9529-9529 ◽  
Author(s):  
D. Shimizu ◽  
J. H. Peters ◽  
D. Vallboehmer ◽  
H. Kuramochi ◽  
K. Uchida ◽  
...  
Keyword(s):  
Barrett’S Esophagus ◽  
Barrett's Esophagus ◽  
Cyclooxygenase 2 ◽  
Cox 2

Cyclooxygenase-2 (COX-2) mediated anti-apoptosis may occur via Bcl-2 in the progression of Barrett's esophagus to adenocarcinoma

2004 ◽  
Vol 22 (14_suppl) ◽  
pp. 9529-9529
Author(s):  
D. Shimizu ◽  
J. H. Peters ◽  
D. Vallboehmer ◽  
H. Kuramochi ◽  
K. Uchida ◽  
...  
Keyword(s):  
Barrett’S Esophagus ◽  
Barrett's Esophagus ◽  
Cyclooxygenase 2 ◽  
Cox 2

scholarly journals Increasing cyclooxygenase-2 (cox-2) gene expression in the progression of Barrett's esophagus to adenocarcinoma correlates with that ofBcl-2

2006 ◽  
Vol 119 (4) ◽  
pp. 765-770 ◽  
Author(s):  
Daisuke Shimizu ◽  
Daniel Vallböhmer ◽  
Hidekazu Kuramochi ◽  
Kazumi Uchida ◽  
Sylke Schneider ◽  
...  
Keyword(s):  
Gene Expression ◽  
Barrett’S Esophagus ◽  
Barrett's Esophagus ◽  
Cyclooxygenase 2 ◽  
Cox 2

scholarly journals Is Malignant Potential of Barrett’s Esophagus Predictable by Endoscopy Findings?

Life ◽  
2020 ◽  
Vol 10 (10) ◽  
pp. 244
Author(s):  
Yuji Amano ◽  
Norihisa Ishimura ◽  
Shunji Ishihara
Keyword(s):  
Protein Expression ◽  
Barrett’S Esophagus ◽  
Barrett's Esophagus ◽  
Cellular Proliferation ◽  
Narrow Band Imaging ◽  
Malignant Potential ◽  
Cyclooxygenase 2 ◽  
Neoplastic Progression ◽  
White Light Endoscopy ◽  
Endoscopic Findings

Given that endoscopic findings can be used to predict the potential of neoplastic progression in Barrett’s esophagus (BE) cases, the detection rate of dysplastic Barrett’s lesions may become higher even in laborious endoscopic surveillance because a special attention is consequently paid. However, endoscopic findings for effective detection of the risk of neoplastic progression to esophageal adenocarcinoma (EAC) have not been confirmed, though some typical appearances are suggestive. In the present review, endoscopic findings that can be used predict malignant potential to EAC in BE cases are discussed. Conventional results obtained with white light endoscopy, such as length of BE, presence of esophagitis, ulceration, hiatal hernia, and nodularity, are used as indicators of a higher risk of neoplastic progression. However, there are controversies in some of those findings. Absence of palisade vessels may be also a new candidate predictor, as that reveals degree of intense inflammation and of cyclooxygenase-2 protein expression with accelerated cellular proliferation. Furthermore, an open type of mucosal pattern and enriched stromal blood vessels, which can be observed by image-enhanced endoscopy, including narrow band imaging, have been confirmed as factors useful for prediction of neoplastic progression of BE because they indicate more frequent cyclooxygenase-2 protein expression along with accelerated cellular proliferation. Should the malignant potential of BE be shown predictable by these endoscopic findings, that would simplify methods used for an effective surveillance, because patients requiring careful monitoring would be more easily identified. Development in the near future of a comprehensive scoring system for BE based on clinical factors, biomarkers and endoscopic predictors is required.

582 Cyclooxygenase-2 Expression in Esophageal Epithelium Before and After Photodynamic Therapy for Barrett's Esophagus

2008 ◽  
Vol 134 (4) ◽  
pp. A-79 ◽  
Author(s):  
Patrick S. Yachimski ◽  
Mari Mino-Kenudson ◽  
Margaret E. Sherwood ◽  
William P. Puricelli ◽  
Norman S. Nishioka ◽  
...  
Keyword(s):  
Photodynamic Therapy ◽  
Barrett’S Esophagus ◽  
Barrett's Esophagus ◽  
Cyclooxygenase 2 ◽  
Esophageal Epithelium ◽  
Before And After

scholarly journals Despite Transcriptional and Functional Coordination, Cyclooxygenase-2 and Microsomal Prostaglandin E Synthase-1 Largely Reside in Distinct Lipid Microdomains in WISH Epithelial Cells

2005 ◽  
Vol 53 (11) ◽  
pp. 1391-1401 ◽  
Author(s):  
William E. Ackerman IV ◽  
John M. Robinson ◽  
Douglas A. Kniss
Keyword(s):  
High Resolution ◽  
Epithelial Cells ◽  
Cyclooxygenase 2 ◽  
Prostaglandin E ◽  
Potential Mechanism ◽  
Prostaglandin E Synthase ◽  
Lipid Microdomains ◽  
Cox 2 ◽  
Cytokine Stimulation ◽  
Soluble Fractions

Cytokine-induced prostaglandin (PG)E2 synthesis requires increased expression of cyclooxygenase-2 (COX-2) in human WISH epithelial cells. Recently, an inducible downstream PGE synthase (microsomal PGE synthase-1, mPGES-1) has been implicated in this inflammatory pathway. We evaluated cooperation between COX-2 and mPGES-1 as a potential mechanism for induced PGE2 production in WISH cells. Cytokine stimulation led to increased expression of both enzymes. Selective pharmacological inhibition of these enzymes demonstrated that induced PGE2 release occurred through a dominant COX-2/mPGES-1 pathway. Unexpectedly, immunofluorescent microscopy revealed that the expression of these enzymes was not tightly coordinated among cells after cytokine challenge. Within cells expressing high levels of both mPGES-1 and COX-2, immunolabeling of high-resolution semithin cryosections revealed that COX-2 and mPGES-1 were largely segregated to distinct regions within continuous intracellular membranes. Using biochemical means, it was further revealed that the majority of mPGES-1 resided within detergent-insoluble membrane fractions, whereas COX-2 was found only in detergent-soluble fractions. We conclude that although mPGES-1 and COX-2 show transcriptional and functional coordination in cytokine-induced PGE2 synthesis, complementary morphological and biochemical data suggest that a majority of intracellular mPGES-1 and COX-2 are segregated to discrete lipid microdomains in WISH epithelial cells.

Cyclooxygenase 2 expression in Barrett's esophagus and adenocarcinoma: Ex vivo induction by bile salts and acid exposure

2000 ◽  
Vol 118 (3) ◽  
pp. 487-496 ◽  
Author(s):  
Vivian N. Shirvani ◽  
Rodica Ouatu-Lascar ◽  
Baljeet S. Kaur ◽  
M.Bishr Omary ◽  
George Triadafilopoulos
Keyword(s):  
Barrett’S Esophagus ◽  
Barrett's Esophagus ◽  
Bile Salts ◽  
Ex Vivo ◽  
Cyclooxygenase 2 ◽  
Acid Exposure
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