Sa1633 - Higher Degrees of Dysplasia are Associated with Poor Quality of Life in Barrett's Esophagus Patients Referred for Endoscopic Eradication Therapy: Results from a Multicenter Cohort Study

2018 ◽  
Vol 154 (6) ◽  
pp. S-335-S-336
Author(s):  
Samuel Han ◽  
Rena Yadlapati ◽  
Violette C. Simon ◽  
Eze Ezekwe ◽  
Dayna S. Early ◽  
...  
Keyword(s):  
Quality Of Life ◽  
Cohort Study ◽  
Barrett’S Esophagus ◽  
Barrett's Esophagus ◽  
Eradication Therapy ◽  
Poor Quality ◽  
Multicenter Cohort Study ◽  
Multicenter Cohort

Adverse Events Related to Endoscopic Eradication Therapy (EET) in Barrett's Esophagus (BE): Results From a Multicenter Cohort Study

2017 ◽  
Vol 152 (5) ◽  
pp. S63-S64
Author(s):  
Joshua C. Obuch ◽  
Birtukan Cinnor ◽  
Gregory L. Austin ◽  
Patrick Blatchford ◽  
Megan Boniface ◽  
...  
Keyword(s):  
Cohort Study ◽  
Adverse Events ◽  
Barrett’S Esophagus ◽  
Barrett's Esophagus ◽  
Eradication Therapy ◽  
Multicenter Cohort Study ◽  
Multicenter Cohort

scholarly journals Severe symptoms and very low quality-of-life among outpatients newly diagnosed with advanced cancer: data from a multicenter cohort study

2020 ◽  
Vol 28 (11) ◽  
pp. 5547-5555
Author(s):  
Waldemar Siemens ◽  
Stefan S. Schönsteiner ◽  
Claudia Lorena Orellana-Rios ◽  
Ulrike Schaekel ◽  
Jens Kessler ◽  
...  
Keyword(s):  
Quality Of Life ◽  
Palliative Care ◽  
Cohort Study ◽  
Advanced Cancer ◽  
Physical Symptoms ◽  
Newly Diagnosed ◽  
Multicenter Cohort Study ◽  
European Organization ◽  
Multicenter Cohort

Abstract Purpose The aim of this study was to identify symptoms of severe intensity or very low scores for quality of life (QoL) domains in newly diagnosed outpatients with advanced cancer. Methods This multicenter cohort study from a state-wide palliative care network included adult outpatients with advanced cancer diagnosed within the preceding 8 weeks from four comprehensive cancer centers (DRKS00006162, registered on 19 May 2014). We used the Palliative Outcome Scale (POS), Hospital Anxiety and Depression Scale, and European Organization for Research and Treatment of Cancer QoL Questionnaire-C30. For each questionnaire, cut-off scores defined symptoms and QoL domains that were considered “severe” or “very low.” Results Of 3155 patients screened, 481/592 (81.3%) were analyzed (mean age 62.4; women n = 245, 50.9%). We identified 324/481 (67.4%) patients experiencing at least one severe symptom or a very low QoL domain (median 2; range 0 to 16). Role functioning (n = 180, 37.4%), fatigue (n = 162, 33.7%), and social functioning (n = 126, 26.2%) were most commonly affected. QoL was very low in 89 patients (18.5%). Women experienced more anxiety symptoms, fatigue, and had lower POS scores. Patients often mentioned physical symptoms and fears of adverse events resulting from disease-modifying therapies (e.g., chemotherapy) as most relevant problems. Conclusions Already within the first 8 weeks after diagnosis, the majority of patients reported at least one severe symptom or a very low QoL domain. Gender differences were evident. The findings illustrate the value of early routine assessment of patient burden and the development of multi-professional and interdisciplinary palliative care.

Reduced Esophageal Contractility Is Associated with Dysplasia Progression in Barrett’s Esophagus: A Multicenter Cohort Study

2020 ◽  
Vol 65 (12) ◽  
pp. 3631-3638 ◽  
Author(s):  
Rena Yadlapati ◽  
Joseph Triggs ◽  
Farhan Quader ◽  
Swathi Eluri ◽  
Shweta Bhatia ◽  
...  
Keyword(s):  
Cohort Study ◽  
Barrett’S Esophagus ◽  
Barrett's Esophagus ◽  
Multicenter Cohort Study ◽  
Multicenter Cohort ◽  
Esophageal Contractility
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