Comparison of nifedipine, verapamil, diltiazem, flunarizine Ca++-antagonist activity on guinea pig taenia caeci

1988 ◽  
Vol 20 ◽  
pp. 158
Author(s):  
A. Fossati ◽  
M. Bozzi ◽  
M.G. Vimercati
Keyword(s):  
Guinea Pig ◽  
Antagonist Activity ◽  
Ca Antagonist

Electrophysiologic Effects of a Novel Ca Antagonist, SA2572, in Isolated Rabbit and Guinea Pig Hearts

1988 ◽  
Vol 12 (1) ◽  
pp. 65-71 ◽  
Author(s):  
Nobuaki Miyawaki ◽  
Tatsuji Furuta ◽  
Tatsuro Shigei
Keyword(s):  
Guinea Pig ◽  
Ca Antagonist

Opioid antagonist peptides derived from κ-casein

1989 ◽  
Vol 56 (3) ◽  
pp. 363-366 ◽  
Author(s):  
Hideo Chiba ◽  
Fumito Tani ◽  
Masaaki Yoshikawa
Keyword(s):  
Guinea Pig ◽  
Synthetic Peptide ◽  
Opioid Antagonist ◽  
Opioid Antagonists ◽  
Guinea Pig Ileum ◽  
Antagonist Activity ◽  
Reverse Phase Hplc ◽  
Reverse Phase ◽  
Enzymic Digestion ◽  
Antagonist Peptides

SummaryOpioid antagonists were sought in the fragments of κ-casein which were obtained by chemical synthesis and enzymic digestion. A synthetic bovine κ-casein peptide (35–41), Tyr-Pro-Ser-Tyr-Gly-Leu-Asn (casoxin A) showed opioid antagonist activity at 200 μM in the guinea pig ileum assay. A synthetic peptide Tyr-Pro-Tyr-Tyr (casoxin B) which is found in bovine and human κ-casein, also showed opioid antagonist activity at 100 μM. Another opioid antagonist peptide (casoxin C) was isolated from tryptic digests of bovine κ-casein by reverse-phase HPLC. The structure of the peptide was Tyr-Ile-Pro-Ile-Gln-Tyr-Val-Leu-Ser-Arg, which corresponded to κ-casein (25–34). Casoxin C was active at 5 μM in the guinea pig ileum assay. Thus, bovine κ-casein contains three potential opioid antagonist sequences.

scholarly journals Electrophysiological effects of KW-3049, a novel dihydropyridine type Ca antagonist, on isolated rabbit hearts, sinus nodal tissues and guinea-pig ventricular muscles.

1986 ◽  
Vol 88 (3) ◽  
pp. 179-187 ◽  
Author(s):  
Ikufumi YOSHITAKE ◽  
Kazuhiro KUBO ◽  
Nobuo IKEDA ◽  
Itsuo KODAMA ◽  
Junji TOYAMA ◽  
...  
Keyword(s):  
Guinea Pig ◽  
Ca Antagonist ◽  
Electrophysiological Effects

Synthesis and Ca-Antagonist Activity of Some Benzhydryl Derivatives

1989 ◽  
Vol 322 (12) ◽  
pp. 873-878
Author(s):  
Stefano Corsano ◽  
Giovannella Strappaghetti ◽  
Elsa Di Domenico ◽  
Livio Brasili ◽  
Maria Teresa Picchio
Keyword(s):  
Antagonist Activity ◽  
Ca Antagonist
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