The conversion of a diazolactam to an α-methylenelactam: An entrance to new conformationally restricted inhibitors of angiotensin-converting enzyme

Gary A Flynn; Douglas W Beight; Edward W Huber; Philippe Bey

doi:10.1016/s0040-4039(00)94635-5

The conversion of a diazolactam to an α-methylenelactam: An entrance to new conformationally restricted inhibitors of angiotensin-converting enzyme

Tetrahedron Letters ◽

10.1016/s0040-4039(00)94635-5 ◽

1990 ◽

Vol 31 (6) ◽

pp. 815-818 ◽

Cited By ~ 8

Author(s):

Gary A Flynn ◽

Douglas W Beight ◽

Edward W Huber ◽

Philippe Bey

Keyword(s):

Angiotensin Converting Enzyme ◽

Converting Enzyme ◽

Conformationally Restricted

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Conformationally restricted inhibitors of angiotensin-converting enzyme. Synthesis and computations

Journal of Medicinal Chemistry ◽

10.1021/jm00152a014 ◽

1986 ◽

Vol 29 (2) ◽

pp. 251-260 ◽

Cited By ~ 67

Author(s):

Eugene D. Thorsett ◽

Elbert E. Harris ◽

Susan D. Aster ◽

Elwood R. Peterson ◽

James P. Snyder ◽

...

Keyword(s):

Angiotensin Converting Enzyme ◽

Enzyme Synthesis ◽

Converting Enzyme ◽

Conformationally Restricted

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Dipeptide mimics. Conformationally restricted inhibitors of angiotensin-converting enzyme

Biochemical and Biophysical Research Communications ◽

10.1016/s0006-291x(83)80131-4 ◽

1983 ◽

Vol 111 (1) ◽

pp. 166-171 ◽

Cited By ~ 25

Author(s):

E.D. Thorsett ◽

E.E. Harris ◽

S. Aster ◽

E.R. Peterson ◽

D. Taub ◽

...

Keyword(s):

Angiotensin Converting Enzyme ◽

Converting Enzyme ◽

Conformationally Restricted

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ChemInform Abstract: Conformationally Restricted Inhibitors of Angiotensin Converting Enzyme: Synthesis and Computations.

Chemischer Informationsdienst ◽

10.1002/chin.198623246 ◽

1986 ◽

Vol 17 (23) ◽

Author(s):

E. D. THORSETT ◽

E. E. HARRIS ◽

S. D. ASTER ◽

E. R. PETERSON ◽

J. P. SNYDER ◽

...

Keyword(s):

Angiotensin Converting Enzyme ◽

Enzyme Synthesis ◽

Converting Enzyme ◽

Conformationally Restricted

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ChemInform Abstract: The Conversion of a Diazolactam (III) to an α-Methylenelactam (VIII): An Entrance to New Conformationally Restricted Inhibitors, e.g. (XII), of Angiotensin-Converting Enzyme.

ChemInform ◽

10.1002/chin.199043298 ◽

1990 ◽

Vol 21 (43) ◽

Author(s):

G. A. FLYNN ◽

D. W. BEIGHT ◽

E. W. HUBER ◽

P. BEY

Keyword(s):

Angiotensin Converting Enzyme ◽

Converting Enzyme ◽

Conformationally Restricted

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Design, synthesis, and physicochemical properties of a novel, conformationally restricted 2,3-dihydro-1,3,4-thiadiazole-containing angiotensin converting enzyme inhibitor which is preferentially eliminated by the biliary route in rats

Journal of Medicinal Chemistry ◽

10.1021/jm00105a066 ◽

1991 ◽

Vol 34 (1) ◽

pp. 439-447 ◽

Cited By ~ 13

Author(s):

Colin Bennion ◽

Roger C. Brown ◽

Anthony R. Cook ◽

Carol N. Manners ◽

David W. Payling ◽

...

Keyword(s):

Angiotensin Converting Enzyme ◽

Physicochemical Properties ◽

Angiotensin Converting Enzyme Inhibitor ◽

Enzyme Inhibitor ◽

Converting Enzyme ◽

Design Synthesis ◽

Converting Enzyme Inhibitor ◽

Conformationally Restricted

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An acyl-iminium ion cyclization route to a novel conformationally restricted dipeptide mimic: applications to angiotensin-converting enzyme inhibition

Journal of the American Chemical Society ◽

10.1021/ja00259a068 ◽

1987 ◽

Vol 109 (25) ◽

pp. 7914-7915 ◽

Cited By ~ 70

Author(s):

Gary A. Flynn ◽

Eugene L. Giroux ◽

Richard C. Dage

Keyword(s):

Angiotensin Converting Enzyme ◽

Enzyme Inhibition ◽

Angiotensin Converting Enzyme Inhibition ◽

Converting Enzyme ◽

Conformationally Restricted ◽

Iminium Ion ◽

Converting Enzyme Inhibition

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ChemInform Abstract: An Acyl-Iminium Ion Cyclization Route to a Novel Conformationally Restricted Dipeptide Mimic: Applications to Angiotensin-Converting Enzyme Inhibition.

ChemInform ◽

10.1002/chin.198813317 ◽

1988 ◽

Vol 19 (13) ◽

Author(s):

G. A. FLYNN ◽

E. L. GIROUX ◽

R. C. DAGE

Keyword(s):

Angiotensin Converting Enzyme ◽

Enzyme Inhibition ◽

Angiotensin Converting Enzyme Inhibition ◽

Converting Enzyme ◽

Conformationally Restricted ◽

Iminium Ion ◽

Converting Enzyme Inhibition

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ChemInform Abstract: Design, Synthesis, and Physicochemical Properties of a Novel, Conformationally Restricted 2,3-Dihydro-1,3,4-thiadiazole-Containing Angiotensin Converting Enzyme Inhibitor which is Preferentially Eliminated by the Biliary Route in Rats

ChemInform ◽

10.1002/chin.199124149 ◽

2010 ◽

Vol 22 (24) ◽

pp. no-no

Author(s):

C. BENNION ◽

R. C. BROWN ◽

A. R. COOK ◽

C. N. MANNERS ◽

D. W. PAYLING ◽

...

Keyword(s):

Angiotensin Converting Enzyme ◽

Physicochemical Properties ◽

Angiotensin Converting Enzyme Inhibitor ◽

Enzyme Inhibitor ◽

Converting Enzyme ◽

Design Synthesis ◽

Converting Enzyme Inhibitor ◽

Conformationally Restricted

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Significance Of Exaggerated Natriuresis After Angiotensin AT1 Receptor Blockade Or Angiotensin- Converting Enzyme Inhibition In Obese Zucker Rats

Clinical and Experimental Pharmacology and Physiology ◽

10.1046/j.1440-1681.2001.3457.x ◽

2001 ◽

Vol 28 (5-6) ◽

pp. 433-440 ◽

Cited By ~ 1

Author(s):

Lakshmi S Tallam ◽

Bhagavan S Jandhyala

Keyword(s):

Angiotensin Converting Enzyme ◽

Enzyme Inhibition ◽

At1 Receptor ◽

Zucker Rats ◽

Angiotensin Converting Enzyme Inhibition ◽

Receptor Blockade ◽

Converting Enzyme ◽

Converting Enzyme Inhibition ◽

Obese Zucker Rats

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Angiotensin-Converting Enzyme Inhibitor-Associated Angioedema

Allergy & Clinical Immunology International - Journal of the World Allergy Organization ◽

10.1027/0838-1925.19.4.164 ◽

2007 ◽

Vol 19 (4) ◽

pp. 164-165

Author(s):

Byol Shin ◽

Richard Lockey

Keyword(s):

Angiotensin Converting Enzyme ◽

Angiotensin Converting Enzyme Inhibitor ◽

Enzyme Inhibitor ◽

Converting Enzyme ◽

Converting Enzyme Inhibitor

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