Definition and measurement of adherence to antiretroviral drugs in HIV-1-infected patients

The Lancet ◽  
1999 ◽  
Vol 353 (9168) ◽  
pp. 1974 ◽  
Author(s):  
Rita Murri ◽  
Adriana Ammassari ◽  
Andrea De Luca ◽  
Antonella Cingolani ◽  
Andrea Antinori
Keyword(s):  
Antiretroviral Drugs ◽  
Hiv 1

scholarly journals Higher Selection Pressure from Antiretroviral Drugs in Vivo Results in Increased Evolutionary Distance in HIV-1 pol

Virology ◽  
1999 ◽  
Vol 259 (1) ◽  
pp. 154-165 ◽  
Author(s):  
Huldrych F. Günthard ◽  
Andrew J. Leigh-Brown ◽  
Richard T. D'Aquila ◽  
Victoria A. Johnson ◽  
Daniel R. Kuritzkes ◽  
...  
Keyword(s):  
Selection Pressure ◽  
Antiretroviral Drugs ◽  
Evolutionary Distance ◽  
Hiv 1

Factors influencing virological response to antiretroviral drugs in cerebrospinal fluid of advanced HIV-1-infected patients

AIDS ◽  
2002 ◽  
Vol 16 (14) ◽  
pp. 1867-1876 ◽  
Author(s):  
Andrea Antinori ◽  
Maria Letizia Giancola ◽  
Susanna Grisetti ◽  
Fabio Soldani ◽  
Lucia Alba ◽  
...  
Keyword(s):  
Cerebrospinal Fluid ◽  
Virological Response ◽  
Antiretroviral Drugs ◽  
Factors Influencing ◽  
Hiv 1

A case of transposition of the great arteries in a female infant of a HIV-1-infected woman. Potential teratogenic effects of antiretroviral drugs

2006 ◽  
Vol 1 (1) ◽  
pp. 86-88 ◽  
Author(s):  
Giuseppe Murdaca ◽  
Sergio Costantini ◽  
Roberto Villa ◽  
Maurizio Setti ◽  
Francesco Puppo ◽  
...  
Keyword(s):  
Antiretroviral Drugs ◽  
Female Infant ◽  
Teratogenic Effects ◽  
Infected Woman ◽  
Hiv 1

scholarly journals ADS-J1 Inhibits Semen-Derived Amyloid Fibril Formation and Blocks Fibril-Mediated Enhancement of HIV-1 Infection

2015 ◽  
Vol 59 (9) ◽  
pp. 5123-5134 ◽  
Author(s):  
Tianrong Xun ◽  
Wenjuan Li ◽  
Jinquan Chen ◽  
Fei Yu ◽  
Wei Xu ◽  
...  
Keyword(s):  
Viral Infection ◽  
Amyloid Fibrils ◽  
Synergistic Effects ◽  
Sexual Transmission ◽  
Prostatic Acid Phosphatase ◽  
Fibril Formation ◽  
Antiretroviral Drugs ◽  
Target Cells ◽  
Additional Function ◽  
Hiv 1

ABSTRACTSemen-derived enhancer of viral infection (SEVI) is composed of amyloid fibrils that can greatly enhance HIV-1 infectivity. By its cationic property, SEVI promotes viral sexual transmission by facilitating the attachment and internalization of HIV-1 to target cells. Therefore, semen-derived amyloid fibrils are potential targets for microbicide design. ADS-J1 is an anionic HIV-1 entry inhibitor. In this study, we explored an additional function of ADS-J1: inhibition of SEVI fibril formation and blockage of SEVI-mediated enhancement of viral infection. We found that ADS-J1 bound to an amyloidogenic peptide fragment (PAP248–286, comprising amino acids 248 to 286 of the enzyme prostatic acid phosphatase), thereby inhibiting peptide assembly into amyloid fibrils. In addition, ADS-J1 binds to mature amyloid fibrils and antagonizes fibril-mediated enhancement of viral infection. Unlike cellulose sulfate, a polyanion that failed in clinical trial to prevent HIV-1 sexual transmission, ADS-J1 shows no ability to facilitate fibril formation. More importantly, the combination of ADS-J1 with several antiretroviral drugs exhibited synergistic effects against HIV-1 infection in semen, with little cytotoxicity to vaginal epithelial cells. Our results suggest that ADS-J1 or a derivative may be incorporated into a combination microbicide for prevention of the sexual transmission of HIV-1.

scholarly journals Primary HIV drug resistance among newly HIV type-1 diagnosed patients in St. Petersburg

2021 ◽  
Vol 13 (1) ◽  
pp. 70-79
Author(s):  
Thierry Ingabire ◽  
A. V. Semenov ◽  
E. V. Esaulenko ◽  
E. B. Zueva ◽  
A. N. Schemelev ◽  
...  
Keyword(s):  
Drug Resistance ◽  
Reverse Transcriptase ◽  
Direct Sequencing ◽  
Population Level ◽  
Multidrug Resistant ◽  
Antiretroviral Drugs ◽  
Drug Resistant ◽  
Resistant Virus ◽  
Primary Drug Resistance ◽  
Hiv 1

There is concern that the widespread use of antiretroviral drugs (ARV) to treat human immunodeficiency virus 1 (HIV-1) infection may result in the emergence of transmission of drug-resistant virus among persons newly infected with HIV-1. Russia is one of a growing number of countries in the world where drug-resistant HIV is becoming a serious health problem because it has the potential to compromise the efficacy of antiretroviral therapy (ART) at the population level.Materials and methods. We performed a genetic analysis of the HIV-1 plasma derived pol gene among the newly diagnosed ART-naïve HIV-1 infected patients during the period from November 2018 to October 2019 in the St. Petersburg Clinical Infectious Diseases Hospital named after S.P. Botkin. We used reverse transcriptase polymerase chain reaction (RT-PCR) followed by direct sequencing of PCR products to determine the prevalence of primary drug resistance (PDR) conferring mutations. HIV-1 genotypes were determined by phylogenetic analysis.Results. The predominant HIV-1 subtype was A1 (87.2%), followed by B (11.8%) and CRF06_cpx (1%). The overall prevalence of PDR was 11%. Virus with known resistance-conferring mutations to any nucleoside reverse transcriptase inhibitors (NRTIs) was found in 8 individuals, to any non NRTIs in 5 subjects, and to any protease inhibitors in 1 case. Multidrug-resistant virus was identified in 2 individuals (2%).Conclusion. The distribution of HIV-1 genotypes in St. Petersburg, Russia is diverse. The emerging prevalence of PDR in ART-naïve patients demonstrates the significance of constant monitoring due to the challenges it presents towards treatment.

Sign in / Sign up

Export Citation Format

Share Document