Differential regulation of IFN-γ, IL-10 and inducible NO synthase in human T cells by cyclic AMP dependent transmembrane signal transduction pathway

1997 ◽  
Vol 56 (1-3) ◽  
pp. 385
Author(s):  
H Shin
Keyword(s):  
Signal Transduction ◽  
T Cells ◽  
Cyclic Amp ◽  
Signal Transduction Pathway ◽  
Differential Regulation ◽  
No Synthase ◽  
Transduction Pathway ◽  
Inducible No Synthase ◽  
Human T Cells

REGULATION OF IL-17, IFN-γ AND IL-10 IN HUMAN CD8+T CELLS BY CYCLIC AMP-DEPENDENT SIGNAL TRANSDUCTION PATHWAY

Cytokine ◽  
1998 ◽  
Vol 10 (11) ◽  
pp. 841-850 ◽  
Author(s):  
Hyun Chul K. Shin ◽  
Naima Benbernou ◽  
Hakim Fekkar ◽  
Stephane Esnault ◽  
Moncef Guenounou
Keyword(s):  
Signal Transduction ◽  
T Cells ◽  
Cyclic Amp ◽  
Cd8 T Cells ◽  
Signal Transduction Pathway ◽  
Transduction Pathway ◽  
Dependent Signal ◽  
Ifn Γ

Involvement of cyclic AMP-dependent protein kinases in the signal transduction pathway for interleukin-1

1990 ◽  
Vol 10 (7) ◽  
pp. 3824-3827
Author(s):  
M Chedid ◽  
S B Mizel
Keyword(s):  
Signal Transduction ◽  
Cyclic Amp ◽  
Protein Kinases ◽  
Gene Transcription ◽  
Interleukin 1 ◽  
Signal Transduction Pathway ◽  
Cell Types ◽  
Specific Protein ◽  
Transduction Pathway ◽  
Dependent Protein

Expression of a highly specific protein inhibitor for cyclic AMP-dependent protein kinases in interleukin-1 (IL-1)-responsive cells blocked IL-1-induced gene transcription that was driven by the kappa immunoglobulin enhancer or the human immunodeficiency virus long terminal repeat. This inhibitor did not affect protein kinase C-mediated gene transcription, suggesting that cyclic AMP-dependent protein kinases are involved in the signal transduction pathway for IL-1 in a number of responsive cell types.

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