Hepatocellular carcinoma and rheumatoid arthritis: a 10-year population-based propensity-score matched cohort study in Taiwan

2017 ◽  
Vol 66 (1) ◽  
pp. S218-S219
Author(s):  
C.-S. Hsu ◽  
H.-C. Lang ◽  
K.-Y. Huang ◽  
C.-L. Chen
2021 ◽  
Author(s):  
Aysegul Erman ◽  
Sharmistha Mishra ◽  
Kali Barrett ◽  
Stephen Mac ◽  
David MJ Naimark ◽  
...  

Background: As the transmission of SARS-CoV-2 variants intensifies globally, the burden of COVID-19 on the already strained health systems is becoming increasingly concerning. While there is growing literature on the effects of various variants-of-concern (VOC) on increased transmission, the extent to which VOCs may lead to more severe disease remains debated. Methods: In the current analysis, we use a population-based propensity-score matched cohort study of all incident laboratory-confirmed COVID-19 cases with VOC testing in Ontario, Canada to estimate healthcare resource use and health outcomes attributable to VOCs introduced to Ontario between January 1 and April 9, 2021, relative to the previously circulating wild-type strain. Results: We find that VOCs are associated with a higher odds of hospitalisation (odds ratio [OR], 2.25; 95% confidence interval [CI], 2.10-2.40) and ICU admission (OR, 3.31; 95%CI, 2.84-3.86); as well as with a higher odds of mortality for both the general COVID-19 population (OR 1.75; 1.47-2.09) and hospitalised cases (OR, 1.62; 95%CI, 1.23-2.15). Conclusion: Taken together, these findings suggest that health systems may face increased demand for healthcare resources as VOCs predominate worldwide in view of low global vaccination coverage.


CNS Drugs ◽  
2020 ◽  
Vol 34 (2) ◽  
pp. 197-206 ◽  
Author(s):  
Kim S. J. Lao ◽  
Angel Y. S. Wong ◽  
Ian C. K. Wong ◽  
Frank M. C. Besag ◽  
W. C. Chang ◽  
...  

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