Immunohistochemical Study of Papillary Thyroid Carcinoma and Possible Papillary Thyroid Carcinoma-related Benign Thyroid Nodules

2000 ◽  
Vol 196 (8) ◽  
pp. 533-540 ◽  
Author(s):  
Kien T. Mai ◽  
Jason C. Ford ◽  
Hossein M. Yazdi ◽  
D. Garth Perkins ◽  
A. Susan Commons
Keyword(s):  
Papillary Thyroid Carcinoma ◽  
Thyroid Carcinoma ◽  
Thyroid Nodules ◽  
Immunohistochemical Study ◽  
Papillary Thyroid ◽  
Benign Thyroid Nodules ◽  
Benign Thyroid

T2* mapping at 3.0T MRI for differentiation of papillary thyroid carcinoma from benign thyroid nodules

2015 ◽  
Vol 43 (4) ◽  
pp. 956-961 ◽  
Author(s):  
Ruoyang Shi ◽  
Qiuying Yao ◽  
Lianming Wu ◽  
Qinyi Zhou ◽  
Qing Lu ◽  
...  
Keyword(s):  
Papillary Thyroid Carcinoma ◽  
Thyroid Carcinoma ◽  
Thyroid Nodules ◽  
T2 Mapping ◽  
Papillary Thyroid ◽  
3.0T Mri ◽  
Benign Thyroid Nodules ◽  
Benign Thyroid

scholarly journals Altered expression of DLG1-AS1 distinguished papillary thyroid carcinoma from benign thyroid nodules

2019 ◽  
Vol 19 (1) ◽  
Author(s):  
Tao He ◽  
Huan Wang ◽  
Jiangming Sun ◽  
Jie Wu ◽  
Fakuo Gong ◽  
...  
Keyword(s):  
Papillary Thyroid Carcinoma ◽  
Thyroid Carcinoma ◽  
Thyroid Nodules ◽  
Curve Analysis ◽  
Healthy Controls ◽  
Papillary Thyroid ◽  
Roc Curve Analysis ◽  
Altered Expression ◽  
Benign Thyroid Nodules ◽  
Benign Thyroid

Abstract Background Benign thyroid nodules (BTN) are frequently diagnosed as papillary thyroid carcinoma (PTC), leading to unnecessary treatment. We found that plasma lncRNA DLG1-AS1 was upregulated in PTC patients but not in BTN patients and healthy controls. Methods In this study DLG1-AS1 and miR-199a-3p in plasma of both PTC patients and BTN patients were detected by qPCR. ROC curve analysis was performed for diagnostic analysis. Overexpression experiments were performed to analyze the interaction between DLG1-AS1 and miR-199a-3p. CCK-8 assay was performed to analyze cell proliferation. Results In this study, upregulation of DLG1-AS1 distinguished PTC patients from BTN patients and healthy controls. Plasma miR-199a-3p was downregulated in PTC patients compared with healthy controls and BTN patients. Plasma levels of miR-199a-3p were inversely correlated in PTC patients, but not in BTN patients and healthy controls. miR-199a-3p overexpression failed to significantly affect DLG1-AS1, while DLG1-AS1 overexpression resulted in downregulated miR-199a-3p, In addition, DLG1-AS1 overexpression promoted the proliferation of PTC cells. miR-199a-3p overexpression played an opposite role and attenuated the effects of DLG1-AS1 overexpression. Conclusions Therefore, DLG1-AS1 may promote PTC by downregulating miR-199a-3p.

scholarly journals MicroRNA Expression Profiles in Papillary Thyroid Carcinoma, Benign Thyroid Nodules and Healthy Controls

2016 ◽  
Vol 7 (7) ◽  
pp. 803-809 ◽  
Author(s):  
Ebru Esin Yoruker ◽  
Duygu Terzioglu ◽  
Serkan Teksoz ◽  
Fatma Ezel Uslu ◽  
Ugur Gezer ◽  
...  
Keyword(s):  
Papillary Thyroid Carcinoma ◽  
Thyroid Carcinoma ◽  
Thyroid Nodules ◽  
Expression Profiles ◽  
Microrna Expression ◽  
Healthy Controls ◽  
Papillary Thyroid ◽  
Benign Thyroid Nodules ◽  
Benign Thyroid

LncRNAs SNHG12 and LINC00152 were associated with progression of patients with papillary thyroid carcinoma

2019 ◽  
Vol 15 (36) ◽  
pp. 4167-4179 ◽  
Author(s):  
Jianqiu Liu ◽  
Xinyue Tang ◽  
Jing Lv ◽  
Xiaowei Peng ◽  
Ke Zhang ◽  
...  
Keyword(s):  
Gene Expression ◽  
Papillary Thyroid Carcinoma ◽  
Operating Characteristic ◽  
Thyroid Nodules ◽  
Diagnostic Value ◽  
Gene Expression Omnibus ◽  
Papillary Thyroid ◽  
Normal Tissues ◽  
Benign Thyroid Nodules ◽  
Benign Thyroid

Aim: To investigate the clinical roles of LINC00152 and SNHG12 in papillary thyroid carcinoma (PTC). Methods: LINC00152 and SNHG12 expression was sought and analysis in gene expression omnibus, The Cancer Genome Atlas and GEPIA datasets. Tumor and adjacent normal tissues were collected from 97 PTC and 44 benign thyroid nodules patients. The expression was evaluated by quantitative real-time polymerase chain reaction. The association between the expression level and clinicopathologic characteristics was analyzed by χ2 test. Receiver operating characteristic curves were plotted to evaluate the diagnostic value. Results: The expression of SNHG12 and LINC00152 were significantly higher in PTC tissues than in adjacent normal tissues not only in gene expression omnibus database but the validated samples. More interesting, LINC00152 expression level was also significantly higher in PTC tissues than that in benign thyroid nodules. The upregulation of LINC00152 and SNHG12 was associated with the malignant progression of PTC. Receiver operating characteristic curve analysis also demonstrated that there was a good trend, which indicates that they may have certain diagnostic value. Conclusion: LINC00152 and SNHG12 might serve as serve as potential related molecules of PTC.

scholarly journals Preoperative Thyrotropin Serum Concentrations Gradually Increase from Benign Thyroid Nodules to Papillary Thyroid Microcarcinomas Then to Papillary Thyroid Cancers of Larger Size

2012 ◽  
Vol 2012 ◽  
pp. 1-4 ◽  
Author(s):  
Carles Zafon ◽  
Gabriel Obiols ◽  
Juan Antonio Baena ◽  
Josep Castellví ◽  
Belen Dalama ◽  
...  
Keyword(s):  
Thyroid Carcinoma ◽  
Thyroid Nodules ◽  
Final Diagnosis ◽  
Differentiated Thyroid Carcinoma ◽  
Papillary Thyroid ◽  
Preoperative Serum ◽  
Malignant Lesions ◽  
Benign Thyroid Nodules ◽  
Benign Thyroid ◽  
Tsh Levels

We evaluated the preoperative serum thyrotropin (TSH) levels in 386 patients operated on for nodular thyroid disease (NTD). TSH levels for cases with final benign disease and differentiated thyroid carcinoma (DTC) were compared. No evidence of cancer was detected in 310 patients (80.3%), whereas malignancy was present in 76 cases (19.7%). Mean TSH concentration was  mU/L in benign patients and in cases with malignant lesions (). The group of malignancy was subdivided in papillary thyroid carcinoma (PTMC) versus thyroid cancer of larger size (TCLS). Mean TSH was in PTMC and in TCLS. Significant differences were found when all groups (benign, PTMC and TCLS) were compared (). However, pairwise comparisons between them showed that differences were only significant between benign and TCLS groups (). In conclusion, TSH levels were higher in patients with a final diagnosis of DTC. Moreover, it appears that there exists an increment in tumor size as a function of increment in the TSH level.

scholarly journals Re-Evaluation of 162 Malignant Thyroid Nodules that were Interpreted as Benign Based on Ultrasound Findings

2018 ◽  
Vol 4 (04) ◽  
pp. E110-E116
Author(s):  
Tomoko Fujimoto ◽  
Mitsuyoshi Hirokawa ◽  
Ayana Suzuki ◽  
Hisashi Ota ◽  
Maki Oshita ◽  
...  
Keyword(s):  
Papillary Thyroid Carcinoma ◽  
Thyroid Nodules ◽  
Pathological Features ◽  
Pathological Findings ◽  
Papillary Thyroid ◽  
Thyroid Ultrasonography ◽  
Ultrasound Findings ◽  
Oxyphilic Cell ◽  
Benign Thyroid Nodules ◽  
Benign Thyroid

AbstractThe goal of this study was to estimate the risk of malignant thyroid nodules being interpreted as benign based on ultrasound findings and to clarify the pathological features of these malignant nodules. We retrospectively re-evaluated ultrasound and pathological findings for 162 malignant thyroid nodules that were initially interpreted as benign based on ultrasound findings at Kuma Hospital between April 2012 and June 2015.The incidences of malignancy among “benign” thyroid nodules were 0.5% overall and 6.2% among resected nodules. In addition, 82.7% of thyroid nodules that were originally judged to have low or very low suspicion patterns were subsequently re-categorized as having high or intermediate suspicion patterns. The incidences of irregular margins (63.6%) and low echogenicity (36.4%) were higher than those of punctate microcalcification (17.9%) and the taller-than-wide shape (20.4%). Among microcarcinomas, the incidences were 65.7% for irregular margins and 51.4% for low echogenicity. Rim calcification with small extrusive soft tissue components and extrathyroidal extensions were not observed. After re-evaluation, 40.0% of papillary thyroid carcinomas remained benign based on their variants, such as the encapsulated, follicular, macrofollicular, and oxyphilic cell variants. We conclude that more careful observation, especially for lesions with irregular margins and low echogenicity, can help improve the diagnostic accuracy of thyroid ultrasonography. Furthermore, greater care may decrease the incidence of malignancy among thyroid nodules with low or very low suspicion patterns. Some variants of papillary thyroid carcinoma can have benign ultrasound findings.

scholarly journals Papillary thyroid carcinoma with desmoid-type fibromatosis: A clinical, pathological, and immunohistochemical study of 14 cases

2017 ◽  
Vol 64 (10) ◽  
pp. 1017-1023 ◽  
Author(s):  
Nami Takada ◽  
Mitsuyoshi Hirokawa ◽  
Masahiro Ito ◽  
Aki Ito ◽  
Ayana Suzuki ◽  
...  
Keyword(s):  
Papillary Thyroid Carcinoma ◽  
Thyroid Carcinoma ◽  
Immunohistochemical Study ◽  
Papillary Thyroid
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