1040-67 The impact of the national privacy act on the effectiveness and costs of a six-month follow-up study of acute coronary syndromes

The impact of the de-escalation strategy of antiplatelet therapy (APT) on the life expectancy after acute coronary syndromes (ACS) and percutaneous coronary intervention (PCI) requires an assessment in real clinical practice. Into the Russian multicentral observational trial (ORACLE II ClinicalTrials.gov number, NCT04068909), 1803 patients with ACS and PCI indications were enrolled. During 12 months of follow-up, 228 all-cause deaths have occurred. The analysis of death predictors was carried out by the classification tree method. Age, an option of antithrombotic therapy, a history of chronic heart failure, and uric acid level had the greatest prognostic value. The death prediction model’s sensitivity was 82.1% in the training cohort and 79.2% in the test cohort. During the observation period, ticagrelor was replaced with clopidogrel (APT de-escalation) in 357 patients. The groups of patients with different antiplatelet therapy options were adjusted for clinical parameters by the pseudorandomization method. The de-escalation group had the lowerest all-cause death rate. The incidence of bleeding and recurrent nonfatal coronary events in the study groups did not differ significantly. Thus, the APT regimen’s advantage of changing from the maximum in the first weeks after ACS to moderate at follow-up has been confirmed. There is an obvious need to study the possibilities of individualizing antiplatelet therapy in patients after acute coronary syndromes.

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Improving Adherence to Ticagrelor in Patients After Acute Coronary Syndrome: Results from the PROGRESS Trial

Current Vascular Pharmacology ◽

10.2174/1570161117666190524123225 ◽

2020 ◽

Vol 18 (3) ◽

pp. 294-301 ◽

Cited By ~ 1

Author(s):

Mario Crisci ◽

Felice Gragnano ◽

Marco Di Maio ◽

Vincenzo Diana ◽

Elisabetta Moscarella ◽

...

Keyword(s):

Acute Coronary Syndrome ◽

Clinical Practice ◽

Antiplatelet Therapy ◽

Outpatient Clinic ◽

Acute Coronary Syndromes ◽

Dual Antiplatelet Therapy ◽

Coronary Syndrome ◽

Coronary Syndromes ◽

The Impact

Background: Dual antiplatelet therapy (DAPT) with aspirin and ticagrelor is recommended for at least 12 months in patients after an acute coronary syndrome (ACS). However, its underuse and premature discontinuation are common in clinical practice. We aimed to investigate the impact of a dedicated follow-up strategy with clinical visits and counselling on adherence levels to ticagrelor in patients after ACS. Methods: PROGRESS (PROmotinG dual antiplatelet therapy adheREnce in the setting of acute coronary Syndromes) is a prospective, randomized trial enrolling 400 ACS patients treated with ticagrelor. Patients were randomized to be followed-up in a dedicated outpatient clinic (In-person follow-up group, [IN-FU], n=200), or with scheduled for phone interviews only (Telephone follow-up group [TEL-FU], n=200), to assess ticagrelor adherence and related complications. DAPT disruption was defined as an interruption of the administration of the drug due to complications or other reasons of non-adherence, and divided according to the duration into short (1-5 days), temporary (6-30 days) and permanent (≥30 days) disruption. The primary endpoint was the rate of DAPT disruption at 1-year follow-up. Results: The rate of ticagrelor disruption at 1 year follow-up was higher in the TEL-FU group than in the IN-FU group (19.6 vs 5.5%; p<0.0001). The IN-FU group reported a significantly lower rate of short (3.0 vs 8.5%; p=0.012) and permanent (2.0 vs 9.6%; p=0.012) disruption than TEL-FU group. The rate of major bleeding did not differ significantly between the 2 groups (p=0.450). Conclusion: The PROGRESS trial showed a net reduction in DAPT disruption in patients followed-up with clinical (in-person) follow-up visits in a dedicated outpatient clinic compared with those scheduled for phone interviews only.

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Psychiatric comorbidities in acute coronary syndromes: Six-month follow-up study

Indian Journal of Psychiatry ◽

10.4103/psychiatry.indianjpsychiatry_94_18 ◽

2018 ◽

Vol 60 (1) ◽

pp. 60 ◽

Cited By ~ 1

Author(s):

TS Sathyanarayana Rao ◽

DRamya Shruthi ◽

SSunil Kumar ◽

Nagaraj Desai ◽

Rajesh Raman

Keyword(s):

Acute Coronary Syndromes ◽

Psychiatric Comorbidities ◽

Follow Up Study ◽

Coronary Syndromes

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The Use of Oral Beta-Blockers and Clinical Outcomes in Patients with Non-ST-Segment Elevation Acute Coronary Syndromes: a Long-Term Follow-Up Study

Cardiovascular Drugs and Therapy ◽

10.1007/s10557-018-6818-6 ◽

2018 ◽

Vol 32 (5) ◽

pp. 435-442 ◽

Cited By ~ 2

Author(s):

Jose C. Nicolau ◽

Remo H. M. Furtado ◽

Luciano M. Baracioli ◽

Livia M. Lara ◽

Talia F. Dalçóquio ◽

...

Keyword(s):

Clinical Outcomes ◽

Acute Coronary Syndromes ◽

Beta Blockers ◽

St Segment Elevation ◽

Follow Up Study ◽

St Segment ◽

Long Term Follow Up ◽

Coronary Syndromes

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Mortality of patients with acute coronary syndromes still remains high: A follow‐up study of 1188 consecutive patients admitted to a university hospital

Annals of Medicine ◽

10.1080/08037060600997534 ◽

2007 ◽

Vol 39 (1) ◽

pp. 63-71 ◽

Cited By ~ 25

Author(s):

Kjell C. Nikus ◽

Markku J. Eskola ◽

Vesa K. Virtanen ◽

Jarkko Harju ◽

Heini Huhtala ◽

...

Keyword(s):

Acute Coronary Syndromes ◽

University Hospital ◽

Follow Up Study ◽

Coronary Syndromes

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Abstract 2603: Gender Is An Important Determinate For The Predictive Value Of NT-proBNP In Patients Presenting With An Acute Coronary Syndrome

Circulation ◽

10.1161/circ.116.suppl_16.ii_576-c ◽

2007 ◽

Vol 116 (suppl_16) ◽

Author(s):

Michael W Weber ◽

Eva Keil ◽

Michael Stanisch ◽

Holger Nef ◽

Helge Moellmann ◽

...

Keyword(s):

Atrial Fibrillation ◽

Acute Coronary Syndrome ◽

Predictive Value ◽

Acute Coronary Syndromes ◽

Age Groups ◽

Prognostic Information ◽

Coronary Syndrome ◽

Coronary Syndromes ◽

The Impact

Background BNP und NT-proBNP provide prognostic information in patients with acute coronary syndromes (ACS). Even though it is generally accepted, that gender, age and atrial fibrillation are important determinants for BNP respectively NT-proBNP values, there is no data available evaluating the impact of those factors on the predictive value of those biomarkers. Therefore it was our aim to evaluate the predictive value of NT-proBNP for mortality after an ACS in association to gender, age and rhythm Methods and results We included 1123 consecutive patients (age 64±12 years; 342 females) with an ACS within the last 48 hours. Follow up data after median of 204 days were available for 1115 (99%) patients. During the follow up 77 (6.8%) patients died. NT-proBNP values on admission were higher in patients who deceased compared to those who survived (2047 (576 –5624) pg/ml vs. 465 (127–1519) pg/ml; p<0,001). The AUC of the ROC curve for NT-proBNP as a predictor for mortality was 0.714 (p<0.001) and an optimised cut-off value of 1815 pg/ml could be calculated. Patients with NT-proBNP above this cut-off had a significantly higher mortality rate (16% vs. 4%; p<0,001; Log Rank 48; p<0,001)). Even though patients with AF had higher NT-proBNP values as those patients with SR (1952 (770 – 4070) pg/ml vs. 452 (121–1492) pg/ml) NT-proBNP at the same cut-off value of 1815 pg/ml was highly discriminative for mortality (27.9% vs. 7.5%; p<0.022; Log Rank 5.7; p=0,017). Patients with an age above 65 years had higher NT-proBNP values as compared to patients younger than 65 years (894 (255–2642) pg/ml vs. 279 (75–945) pg/ml; p<0,001). However the predictive value of NT-proBNP in both age groups was comparable. Women had higher NT-proBNP values as compared to men (966 (237–2549) pg/ml vs. 407 (102–1273) pg/ml; p<0,001). But in dissimilarity, in women NT-proBNP values above 1815 pg/ml were not associated with a higher mortality and thus were without predictive value (10,6% vs. 6,8%; p<0,304; Log Rank 1,556; p<0,212). Conclusion Gender, age and rhythm are important determinants for NT-proBNP values of patients presenting with an ACS. However, only gender had impact on the predictive value of NT-proBNP for mortality. In women cut-off values need to be adopted.

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An overview of body weight of older persons, including the impact on mortality The national health and nutrition examination survey i-epidemiologic follow-up study

Journal of Clinical Epidemiology ◽

10.1016/0895-4356(91)90126-t ◽

1991 ◽

Vol 44 (8) ◽

pp. 743-753 ◽

Cited By ~ 191

Author(s):

Joan C. Cornoni-Huntley ◽

Tamara B. Harris ◽

Donald F. Everett ◽

Demetrius Albanes ◽

Marc S. Micozzi ◽

...

Keyword(s):

Body Weight ◽

National Health ◽

Older Persons ◽

Nutrition Examination Survey ◽

Follow Up Study ◽

Health And Nutrition ◽

The Impact

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THU0015 The Impact of Biologic Therapies on CD4+ and CD8+ Cell Subsets in Rheumatoid Arthritis: A Long Term Follow-Up Study

Annals of the Rheumatic Diseases ◽

10.1136/annrheumdis-2016-eular.2525 ◽

2016 ◽

Vol 75 (Suppl 2) ◽

pp. 182.3-183

Author(s):

S. Dulic ◽

G. Toldi ◽

Z. Vásárhelyi ◽

A. Balog

Keyword(s):

Rheumatoid Arthritis ◽

Biologic Therapies ◽

Follow Up Study ◽

Long Term Follow Up ◽

Cd8 Cell ◽

The Impact

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Keeping the Flame Lit: The Value of the Long-Term Permanence of a Science Club

Science Communication ◽

10.1177/1075547018814845 ◽

2018 ◽

Vol 41 (1) ◽

pp. 132-143

Author(s):

Miguel García-Guerrero ◽

Bertha Michel-Sandoval ◽

Viridiana Esparza-Manrique ◽

Amelia Rodríguez-Pinedo ◽

Vianey Raudales-Hernández ◽

...

Keyword(s):

Public Communication ◽

Children And Young People ◽

Follow Up Study ◽

School Programs ◽

Science Clubs ◽

The Impact ◽

Science Club ◽

Science Activities

Science clubs are programs that allow people (especially children and youngsters) to meet regularly outside of school programs and engage with science and technology activities. Clubs encourage participants to foster attitudes, capabilities, and knowledge related to STEM fields with the goal of promoting interest and passion about science. As such programs provide big opportunities to improve the impact of public communication of science activities, it is really important to look at the impacts of such programs. Quark Group runs the Children Science Club since 2002, and up to 2016, it developed science recreation activities with 711 children and young people. In order to establish the influence the club had on its participants, we conducted a survey that provided 244 answers. This article presents the findings of this follow-up study.

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