CINACIGUAT, A SOLUBLE GUANYLATE CYCLASE ACTIVATOR, UNLOADS THE HEART IN ACUTE DECOMPENSATED HEART FAILURE

BAY 58–2667, a soluble guanylate cyclase activator, improves cardiopulmonary haemodynamics in acute decompensated heart failure and has a favourable safety profile

BMC Pharmacology ◽

10.1186/1471-2210-7-s1-s9 ◽

2007 ◽

Vol 7 (S1) ◽

Cited By ~ 6

Author(s):

Harald Lapp ◽

Veselin Mitrovic ◽

Norbert Franz ◽

Hubertus Heuer ◽

Michael Buerke ◽

...

Keyword(s):

Heart Failure ◽

Guanylate Cyclase ◽

Safety Profile ◽

Favourable Safety ◽

Favourable Safety Profile ◽

Cinaciguat, a soluble guanylate cyclase activator, unloads the heart but also causes hypotension in acute decompensated heart failure†

European Heart Journal ◽

10.1093/eurheartj/ehs196 ◽

2012 ◽

Vol 34 (1) ◽

pp. 57-67 ◽

Cited By ~ 89

Author(s):

Erland Erdmann ◽

Marc J. Semigran ◽

Markku S. Nieminen ◽

Mihai Gheorghiade ◽

Rahul Agrawal ◽

...

Keyword(s):

Heart Failure ◽

Guanylate Cyclase ◽

The soluble guanylate cyclase activator BAY 58-2667 has a favourable safety profile and improves cardiopulmonary haemodynamics in acute decompensated heart failure

European Journal of Heart Failure Supplements ◽

10.1016/s1567-4215(08)60005-3 ◽

2008 ◽

Vol 7 ◽

pp. 1-1 ◽

Cited By ~ 4

Author(s):

M MITROVIC ◽

H LAPP ◽

N FRANZ ◽

H HEUER ◽

M BUERKE ◽

...

Keyword(s):

Heart Failure ◽

Guanylate Cyclase ◽

Safety Profile ◽

Favourable Safety ◽

Favourable Safety Profile ◽

Population Pharmacokinetics and Pharmacodynamics of Cinaciguat, a Soluble Guanylate Cyclase Activator, in Patients with Acute Decompensated Heart Failure

Clinical Pharmacokinetics ◽

10.2165/11317590-000000000-00000 ◽

2010 ◽

Vol 49 (2) ◽

pp. 119-129 ◽

Cited By ~ 14

Author(s):

Wolfgang Mueck ◽

Reiner Frey

Keyword(s):

Heart Failure ◽

Population Pharmacokinetics ◽

Guanylate Cyclase ◽

Pharmacokinetics And Pharmacodynamics ◽

Population Pharmacokinetics And Pharmacodynamics ◽

Treatment of acute decompensated heart failure with the soluble guanylate cyclase activator cinaciguat: The COMPOSE program – three randomized, controlled, phase IIb studies

Journal of Cardiac Failure ◽

10.1016/j.cardfail.2011.10.004 ◽

2011 ◽

Vol 17 (11) ◽

pp. 971 ◽

Cited By ~ 5

Author(s):

Mihai Gheorghiade ◽

Erland Erdmann ◽

Roberto Ferrari ◽

Gerasimos Filippatos ◽

Philip D. Levy ◽

...

Keyword(s):

Heart Failure ◽

Guanylate Cyclase ◽

Randomized Controlled ◽

792 Cardiorenal actions of the new direct soluble guanylate cyclase activator BAY 58-2667 in experimental congestive heart failure

European Journal of Heart Failure Supplements ◽

10.1016/s1567-4215(03)90524-8 ◽

2003 ◽

Vol 2 (1) ◽

pp. 172-173

Author(s):

G BOERRIGTER ◽

L COSTELLOBOERRIGTER ◽

A CATALIOTTI ◽

T TSURUDA ◽

G HARTY ◽

...

Keyword(s):

Heart Failure ◽

Congestive Heart Failure ◽

Guanylate Cyclase ◽

Praliciguat. Soluble guanylate cyclase activator, Treatment of heart failure with preserved ejection fraction, Treatment of diabetic nephropathy

Drugs of the Future ◽

10.1358/dof.2019.44.4.2927592 ◽

2019 ◽

Vol 44 (4) ◽

pp. 277

Author(s):

K. Rana ◽

J. Reid ◽

R.R. Choksi ◽

T. Lewis ◽

R.F. Goldfaden

Keyword(s):

Heart Failure ◽

Diabetic Nephropathy ◽

Ejection Fraction ◽

Guanylate Cyclase ◽

Preserved Ejection Fraction ◽

Cardiorenal actions of the new heme-independent direct soluble guanylate cyclase activator BAY 58-2667 in experimental congestive heart failure

Journal of Cardiac Failure ◽

10.1016/s1071-9164(03)00214-8 ◽

2003 ◽

Vol 9 (5) ◽

pp. S9

Author(s):

Guido Boerrigter ◽

Lisa C. Costello-Boerrigter ◽

Harald Lapp ◽

Gail J. Harty ◽

Alessandro Cataliotti ◽

...

Keyword(s):

Heart Failure ◽

Congestive Heart Failure ◽

Guanylate Cyclase ◽

Cinaciguat, a soluble guanylate cyclase activator: results from the randomized, controlled, phase IIb COMPOSE programme in acute heart failure syndromes

European Journal of Heart Failure ◽

10.1093/eurjhf/hfs093 ◽

2012 ◽

Vol 14 (9) ◽

pp. 1056-1066 ◽

Cited By ~ 75

Author(s):

Mihai Gheorghiade ◽

Stephen J. Greene ◽

Gerasimos Filippatos ◽

Erland Erdmann ◽

Roberto Ferrari ◽

...

Keyword(s):

Heart Failure ◽

Acute Heart Failure ◽

Guanylate Cyclase ◽

Randomized Controlled ◽

Acute Heart Failure Syndromes ◽

Discovery of the Soluble Guanylate Cyclase Activator Runcaciguat (BAY 1101042)

Journal of Medicinal Chemistry ◽

10.1021/acs.jmedchem.0c02154 ◽

2021 ◽

Author(s):

Michael G. Hahn ◽

Thomas Lampe ◽

Sherif El Sheikh ◽

Nils Griebenow ◽

Elisabeth Woltering ◽

...

Keyword(s):

Guanylate Cyclase ◽