Epileptiform and non-epileptiform paroxysmal activity from isolated cortex after functional hemispherectomy

1997 ◽  
Vol 102 (5) ◽  
pp. 437-442 ◽  
Author(s):  
R.A. Wennberg ◽  
L.F. Quesney ◽  
J.-G. Villemure
Keyword(s):  
Paroxysmal Activity ◽  
Functional Hemispherectomy ◽  
Isolated Cortex

Value of video – EEG findings in children following failed functional hemispherectomy for reoperation selection

2008 ◽  
Vol 39 (01) ◽  
Author(s):  
I Tuxhorn ◽  
K Velayudam ◽  
A Gupta ◽  
D Lachhwani ◽  
E Wyllie ◽  
...  
Keyword(s):  
Functional Hemispherectomy ◽  
Video Eeg

Seizure freedom after functional hemispherectomy and a possible role for the insular cortex: the Dutch experience

2007 ◽  
Vol 107 (4) ◽  
pp. 275-280 ◽  
Author(s):  
Elisabeth A. Cats ◽  
Kuan H. Kho ◽  
Onno van Nieuwenhuizen ◽  
Cornelis W. M. van Veelen ◽  
Peter H. Gosselaar ◽  
...  
Keyword(s):  
Insular Cortex ◽  
Seizure Freedom ◽  
Functional Hemispherectomy ◽  
Dutch Experience

Photosynthesis, translocation, and alginic acid synthesis in Laminaria digitata and Laminaria hyperborea

1972 ◽  
Vol 50 (1) ◽  
pp. 169-176 ◽  
Author(s):  
Johan A. Hellebust ◽  
Arne Haug
Keyword(s):  
Time Course ◽  
Alginic Acid ◽  
Acid Synthesis ◽  
Laminaria Hyperborea ◽  
Short Term ◽  
Fresh Weight Basis ◽  
Mannuronic Acid ◽  
Guluronic Acid ◽  
Isolated Cortex ◽  
Photosynthetic Capacities

New and old tissues of L. digitata blades have very similar photosynthetic capacities on a fresh weight basis. Very little of the photoassimilate goes into alginic acid, or other macromolecular substances in old blade tissues. Less than 1% of the photoassimilated 14C in the old blade portion of a L. digitata blade was translocated to the new blade tissues in a 5-h experiment. In contrast, there is rapid transport of photoassimilate from bark cells to cells of the underlying tissues of L. digitata and L. hyperborea stipe sections. Isolated cortex and medulla tissues of L. digitata stipes have significant photosynthetic capacities, but are probably so strongly shaded by the darkly pigmented bark cells that little photosynthesis can normally occur in these tissues.A larger proportion of the photoassimilated carbon enters alginate in the cortex and medulla than in the bark of L. digitata and L. hyperborea stipes in short-term experiments. The time course for incorporation of photosynthate into alginate in continuous and pulse-labeling experiments indicates the presence of relatively large pools of alginate precursors. A large proportion of the total 14C incorporated into alginate in short-term experiments is found in the "M–M" (mannuronic acid) and "M–G" (alternating mannuronic and guluronic acid) block components.

Paroxysmal activity at Stromboli: lessons from the past

2011 ◽  
Vol 73 (9) ◽  
pp. 1229-1243 ◽  
Author(s):  
Antonella Bertagnini ◽  
Alessio Di Roberto ◽  
Massimo Pompilio
Keyword(s):  
Paroxysmal Activity ◽  
The Past

mTOR Inhibitors as a New Therapeutic Strategy in Treatment Resistant Epilepsy in Hemimegalencephaly: A Case Report

2018 ◽  
Vol 34 (3) ◽  
pp. 132-138 ◽  
Author(s):  
Qi Xu ◽  
Shimrit Uliel-Sibony ◽  
Christopher Dunham ◽  
Harvey Sarnat ◽  
Laura Flores-Sarnat ◽  
...  
Keyword(s):  
Therapeutic Strategy ◽  
Mtor Inhibitor ◽  
De Novo ◽  
Mtor Inhibitors ◽  
Mtor Pathway ◽  
Definitive Treatment ◽  
Malformations Of Cortical Development ◽  
Treatment Resistant ◽  
Seizure Reduction ◽  
Functional Hemispherectomy

Hemimegalencephaly is a hamartomatous malformation of one hemisphere. Functional hemispherectomy, the definitive treatment, is associated with significant morbidity and mortality in early infancy. Dysregulation of the mTOR pathway can result in malformations of cortical development, and mTOR inhibitors can effectively reduce seizures in tuberous sclerosis complex. We report a 6-day-old female with hemimegalencephaly and frequent seizures despite 9 antiseizure medications. At 3 months of age, while awaiting hemispherectomy, an mTOR inhibitor, rapamycin, was initiated by the neurologist. After 1 week of treatment, there was >50% reduction in seizures and total seizure burden, and after 2 weeks, development improved, resulting in deferral of surgery by 2.5 months with an increased body weight. Pathology demonstrated cortical dysplasia with upregulation of the mTOR pathway. Deep-sequencing of brain tissue demonstrated 16% mosaicism for a pathogenic de novo MTOR gene mutation. This case exemplifies how mTOR inhibitors could be considered for seizure reduction in patients with hemimegalencephaly while awaiting surgery.

Density spectral array of BIS VISTA™ monitoring system in a functional hemispherectomy

2018 ◽  
Vol 65 (8) ◽  
pp. 473-476
Author(s):  
C. Luis ◽  
E. Vilà ◽  
L. Moltó ◽  
A. Pardo ◽  
J.L. Fernández Candila ◽  
...  
Keyword(s):  
Monitoring System ◽  
Functional Hemispherectomy
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