Dose response relationship of nuclear changes with fractionated concomitant chemoradiotherapy in assessing chemo-radiosensitivity of peritumoural area in oral squamous cell carcinoma patients

2017 ◽  
Vol 72 ◽  
pp. S106
Author(s):  
M. Kashif ◽  
S. Minhas ◽  
W. Altaf ◽  
A.H. Nagi
Keyword(s):  
Squamous Cell Carcinoma ◽  
Oral Squamous Cell Carcinoma ◽  
Cell Carcinoma ◽  
Squamous Cell ◽  
Dose Response ◽  
Response Relationship ◽  
Concomitant Chemoradiotherapy ◽  
Dose Response Relationship ◽  
Nuclear Changes ◽  
Relationship Of

scholarly journals Evaluation of Various Nuclear Cytological Changes in Normal Buccal Mucosa and Peritumoural Area in Patients with Oral Squamous Cell Carcinoma Receiving Concomitant Chemoradiotherapy

2016 ◽  
Vol 2016 ◽  
pp. 1-8
Author(s):  
Sadia Minhas ◽  
Muhammad Kashif ◽  
A. H. Nagi
Keyword(s):  
Squamous Cell Carcinoma ◽  
Oral Squamous Cell Carcinoma ◽  
Cell Carcinoma ◽  
Squamous Cell ◽  
Buccal Mucosa ◽  
Concomitant Chemoradiotherapy ◽  
Fractionated Radiotherapy ◽  
End Of Treatment ◽  
Before And After ◽  
Nuclear Changes

Objectives. To evaluate the role of serial cytological assay in calculating the nuclear response of contralateral normal buccal mucosa and peritumoural area of squamous cell carcinoma of oral cavity in patients receiving fractionated radiotherapy (RT) and chemotherapy. Materials and Methods. This prospective, nonrandomized study was comprised of 76 histologically confirmed cases of oral squamous cell carcinoma on cyclical chemoradiation treatment. Chemoradiosensitivity was evaluated using serial scrape smears taken before and after immediate exposure to CCRT, at 17th day of CCRT (mid of treatment), and at the end of treatment. The nuclear changes, such as multinucleation, micronucleation, karyorrhexis, karyolysis, nuclear budding, prominent nucleoli, and binucleation occurring in both irradiated cancer cells and contralateral normal buccal mucosa, had a statistically significant dose related increase with concomitant chemoradiotherapy (p<0.05). Conclusion. We recommend regular use of serial cytological assay during CCRT as it may prove to be a valuable tool for assessment of chemoradiosensitivity and persistence of tumour/dysplastic cells after radiotherapy.

Reciprocal relationship of Tn/NF-κB and sTn as an indicator of the prognosis of oral squamous cell carcinoma

2013 ◽  
Vol 64 (5) ◽  
pp. 713-721 ◽  
Author(s):  
Chi-Yu Lin ◽  
Jar-Yi Ho ◽  
Meng-Ti Hsieh ◽  
Hsiao-Ling Chiang ◽  
Jei-Min Chuang ◽  
...  
Keyword(s):  
Squamous Cell Carcinoma ◽  
Oral Squamous Cell Carcinoma ◽  
Cell Carcinoma ◽  
Squamous Cell ◽  
Reciprocal Relationship ◽  
Relationship Of

scholarly journals Relationship of Angiogenesis and Oral Squamous Cell Carcinoma

2017 ◽  
Vol 13 (2) ◽  
pp. 178-185 ◽  
Author(s):  
V. Marla ◽  
V. Hegde ◽  
A. Shrestha
Keyword(s):  
Squamous Cell Carcinoma ◽  
Oral Squamous Cell Carcinoma ◽  
Cell Carcinoma ◽  
Squamous Cell ◽  
Ongoing Research ◽  
Oral Epithelial Dysplasia ◽  
Angiogenic Therapy ◽  
Anti Cancer ◽  
Relationship Of ◽  
Oral Epithelial

Angiogenesis is an important aspect of a variety of physiological and pathological processes; and depends on the alteration of the balance between pro-angiogenic and anti-angiogenic factors. The role of angiogenesis in the progression and metastasis of neoplasm is a well established phenomenon. With regards to oral squamous cell carcinoma, it is a field of ongoing research and requires validation for it being used as a mode of anti-cancer therapy. This review focuses on the concept of angiogenesis, the factors associated with it, the relationship of angiogenesis with oral epithelial dysplasia and oral squamous cell carcinoma; the methods of studying angiogenesis and anti angiogenic therapy.

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