scholarly journals Evaluation of Various Nuclear Cytological Changes in Normal Buccal Mucosa and Peritumoural Area in Patients with Oral Squamous Cell Carcinoma Receiving Concomitant Chemoradiotherapy

2016 ◽  
Vol 2016 ◽  
pp. 1-8
Author(s):  
Sadia Minhas ◽  
Muhammad Kashif ◽  
A. H. Nagi
Keyword(s):  
Squamous Cell Carcinoma ◽  
Oral Squamous Cell Carcinoma ◽  
Cell Carcinoma ◽  
Squamous Cell ◽  
Buccal Mucosa ◽  
Concomitant Chemoradiotherapy ◽  
Fractionated Radiotherapy ◽  
End Of Treatment ◽  
Before And After ◽  
Nuclear Changes

Objectives. To evaluate the role of serial cytological assay in calculating the nuclear response of contralateral normal buccal mucosa and peritumoural area of squamous cell carcinoma of oral cavity in patients receiving fractionated radiotherapy (RT) and chemotherapy. Materials and Methods. This prospective, nonrandomized study was comprised of 76 histologically confirmed cases of oral squamous cell carcinoma on cyclical chemoradiation treatment. Chemoradiosensitivity was evaluated using serial scrape smears taken before and after immediate exposure to CCRT, at 17th day of CCRT (mid of treatment), and at the end of treatment. The nuclear changes, such as multinucleation, micronucleation, karyorrhexis, karyolysis, nuclear budding, prominent nucleoli, and binucleation occurring in both irradiated cancer cells and contralateral normal buccal mucosa, had a statistically significant dose related increase with concomitant chemoradiotherapy (p<0.05). Conclusion. We recommend regular use of serial cytological assay during CCRT as it may prove to be a valuable tool for assessment of chemoradiosensitivity and persistence of tumour/dysplastic cells after radiotherapy.

scholarly journals An erosive lesion of the buccal mucosa revealing an early squamous cell carcinoma

2021 ◽  
Vol 8 ◽  
Author(s):  
Laila Benjelloun ◽  
Saliha Chbicheb
Keyword(s):  
Risk Factors ◽  
Squamous Cell Carcinoma ◽  
Oral Squamous Cell Carcinoma ◽  
Cell Carcinoma ◽  
Squamous Cell ◽  
Buccal Mucosa ◽  
Malignant Lesion ◽  
Malignant Neoplasm ◽  
Early Presentation ◽  
Early Squamous Cell Carcinoma

Oral squamous cell carcinoma is the most common epithelial malignant neoplasm affecting the oral cavity. It accounts for 90% of all oral cancers. It usually arises from a pre-existing potentially malignant lesion, and occasionally de novo. The use of tobacco, betel quid and alcohol are well known risk factors for oral squamous cell carcinoma. Early detection is an important criterion for achieving high cure rate. Occasionally, OSCC may be misdiagnosed because of its variable and innocuous clinical appearance. We report the case of an early presentation of Oral squamous cell carcinoma in a patient aged 70 without preexisting risk factors, with a painful and soft erosion in the buccal mucosa for 2 months. The lesion resembled other benign lesions, but biopsy was mandatory and revealed an early squamous cell carcinoma.

scholarly journals The CLINICOPATHOLOGICAL SPECTRUM OF ORAL SQUAMOUS CELL CARCINOMA AMONG TOBACCO CONSUMERS: AN INSTITUTIONAL STUDY

2020 ◽  
Vol 4 (9) ◽  
Author(s):  
Kiran Arif ◽  
Fouzia Shaikh ◽  
Faraz Ahmed Baig ◽  
Rizma Khan ◽  
Saba Arif
Keyword(s):  
Squamous Cell Carcinoma ◽  
Oral Squamous Cell Carcinoma ◽  
Cell Carcinoma ◽  
Squamous Cell ◽  
Buccal Mucosa ◽  
Viral Infections ◽  
Prognostic Indicators ◽  
Additional Risk ◽  
Fourth Decade ◽  
Oral Malignancies

Background: Oral squamous cell carcinoma (OSCC) constitutes 90% of all oral malignancies. Tobacco products, viral infections and additional risk factors are common etiological elements for this tumor. Objective: The aim of this study is to analyze the clinicopathological and sociodemographic features of patients diagnosed with oral squamous cell carcinoma. Material and Methods: Histologically confirmed 35 OSCC cases were selected for study. The clinicopathological data was obtained from patients and analyzed using SPSS software version 20. Results: Majority of cases was men and diagnosed with disease during fourth decade of life. Buccal mucosa was the common site while gutka chewing was observed as leading habit among our cases. Also, stage II and moderate histological differentiation was predominant among prognostic indicators of OSCC. Conclusion: Our data suggested that men, gutka consumers and early onset of disease are more prevalent characteristics in oral squamous cell carcinoma cases from our population. Most tumors classically affected buccal mucosa and late diagnosis seems to be common among our cases. Keywords: Malignancy, Squamous Cell Carcinoma, Oral Cavity, Tobacco

DETERMINATION AND PROGNOSTIC VALUE OF EXOSOME LEVELS IN ORAL SQUAMOUS CELL CARCINOMA BEFORE AND AFTER SURGERY

2020 ◽  
Vol 129 (1) ◽  
pp. e145-e146
Author(s):  
MARIO PEREZ SAYANS ◽  
STEFANO FAIS ◽  
SAMUEL RODRÍGUEZ ZORRILLA ◽  
CINTIA CHAMORRO PETRONACCI ◽  
ANDRÉS BLANCO CARRIÓN ◽  
...  
Keyword(s):  
Squamous Cell Carcinoma ◽  
Oral Squamous Cell Carcinoma ◽  
Cell Carcinoma ◽  
Squamous Cell ◽  
Prognostic Value ◽  
Before And After
Sign in / Sign up

Export Citation Format

Share Document