Analysis of Intracochlear New Bone and Fibrous Tissue Formation in Human Subjects With Cochlear Implants

2009 ◽  
Vol 2009 ◽  
pp. 99-100
Author(s):  
B.J. Balough
Keyword(s):  
Cochlear Implants ◽  
Human Subjects ◽  
Fibrous Tissue ◽  
Tissue Formation

Analysis of Intracochlear New Bone and Fibrous Tissue Formation in Human Subjects with Cochlear Implants

2007 ◽  
Vol 116 (10) ◽  
pp. 731-738 ◽  
Author(s):  
Peter M. M. C. Li ◽  
Mehmet A. Somdas ◽  
Donald K. Eddington ◽  
Joseph B. Nadol
Keyword(s):  
Word Recognition ◽  
Cochlear Implantation ◽  
Ganglion Cells ◽  
Human Subjects ◽  
Fibrous Tissue ◽  
Spiral Ganglion ◽  
Tissue Formation ◽  
Spiral Ganglion Cell ◽  
Cell Counts ◽  
Temporal Bones

Objectives: In this study we aimed to evaluate new bone and new fibrous tissue formation in the inner ear following cochlear implantation. Methods: Twelve temporal bones from patients who underwent cochlear implantation during life were prepared for histologic study. The specimens were reconstructed by both 2-dimensional and 3-dimensional methods. These reconstructions were used to calculate the total volume and distribution of new bone and new fibrous tissue in the cochlea, the number of spiral ganglion cells, and other histopathologic parameters. Clinical data, including the last-recorded word recognition scores, were obtained from the patients' medical records. Results: New bone and new fibrous tissue were found in all 12 specimens, particularly at the site of cochleostomy. There was a significant correlation between overall damage to the lateral cochlear wall and the total volume of intracochlear new tissue (Spearman rho = .853; p = .0004). The total volume of new tissue did not correlate with word recognition scores or spiral ganglion cell counts. Conclusions: These preliminary results suggest that the degree of damage to the lateral cochlear wall may play an important role in influencing the amount of new tissue formation following cochlear implantation. Intracochlear new tissue does not appear to be an important determinant of performance as measured by word recognition scores or the total number of remaining spiral ganglion cells.

Relaxin attenuates fibrous tissue formation

2001 ◽  
Vol 33 (6) ◽  
pp. A136
Author(s):  
Jiakun Zhang ◽  
Elaine N. Unemori ◽  
Yao Sun ◽  
Karl T. Weber
Keyword(s):  
Fibrous Tissue ◽  
Tissue Formation

In Vivo Monitoring of Osseointegration

2007 ◽  
Author(s):  
Lindsey R. VanSchoiack ◽  
Veronica I. Shubayev ◽  
Robert R. Myers ◽  
James C. Earthman
Keyword(s):  
Fibrous Tissue ◽  
Tissue Formation ◽  
Surgical Implant ◽  
In Vivo Monitoring

The process of osseointegration is the firm anchoring of a surgical implant by the growth of bone around it without fibrous tissue formation at the interface. This process is critical for long-term implant success. The ability to monitor this process in vivo would allow for personalization of loading protocols to increase the rate of implant success overall by ensuring that implants are not over or under loaded during recovery. Accordingly, there is a strong need for an instrument that has the sensitivity to noninvasively measure osseointegration in vivo. One of the objectives of the present study was to assess the performance of an instrumented percussion probe for quantitatively monitoring the osseointegration process.

New bone and fibrous tissue formation around ceramic cochlear implant receiver–stimulators and the measurement of their anchorage in the bony implant bed

2014 ◽  
Vol 15 (6) ◽  
pp. 327-332
Author(s):  
Robert Mlynski ◽  
Kristen Rak ◽  
Stefan Kaulitz ◽  
Fabian Kraus ◽  
Rudolf Hagen ◽  
...  
Keyword(s):  
Cochlear Implant ◽  
Fibrous Tissue ◽  
Tissue Formation ◽  
Implant Bed

THE INFLUENCE OF ADRENAL CORTICO-STEROIDS ON FIBROUS TISSUE FORMATION

1960 ◽  
Vol 240 (3) ◽  
pp. 387-395 ◽  
Author(s):  
ROGER W. REED ◽  
GARDNER C. MCMILLAN ◽  
KARL PINTAR
Keyword(s):  
Fibrous Tissue ◽  
Tissue Formation

Effects of stimulus level on electrode-place discrimination in human subjects with cochlear implants

1999 ◽  
Vol 134 (1-2) ◽  
pp. 105-115 ◽  
Author(s):  
Bryan E Pfingst ◽  
Lisa A Holloway ◽  
Teresa A Zwolan ◽  
Leslie M Collins
Keyword(s):  
Cochlear Implants ◽  
Human Subjects ◽  
Stimulus Level

scholarly journals An Unusual Mechanism of Closure of Muscular Ventricular Septal Defects

2017 ◽  
Vol 2017 ◽  
pp. 1-3 ◽  
Author(s):  
Soham Dasgupta ◽  
Ashraf M. Aly
Keyword(s):  
Congenital Heart Defects ◽  
Congenital Heart ◽  
Heart Defects ◽  
Fibrous Tissue ◽  
Spontaneous Closure ◽  
Muscular Tissue ◽  
Tissue Formation ◽  
Ventricular Septal Defects ◽  
Septal Defects ◽  
Muscular Vsd

Ventricular septal defects (VSDs) are the most common congenital heart defects. Most of the small or moderate size (<6 mm) muscular VSDs close spontaneously within the first two years of life. The usual mechanism of spontaneous closure involves muscular tissue encroachment with superimposed fibrosis or primary fibrous tissue formation around the margins of the defect. We describe an unusual mechanism of spontaneous closure of a muscular VSD.

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