Relaxin attenuates fibrous tissue formation

2001 ◽  
Vol 33 (6) ◽  
pp. A136
Author(s):  
Jiakun Zhang ◽  
Elaine N. Unemori ◽  
Yao Sun ◽  
Karl T. Weber
Author(s):  
Lindsey R. VanSchoiack ◽  
Veronica I. Shubayev ◽  
Robert R. Myers ◽  
James C. Earthman

The process of osseointegration is the firm anchoring of a surgical implant by the growth of bone around it without fibrous tissue formation at the interface. This process is critical for long-term implant success. The ability to monitor this process in vivo would allow for personalization of loading protocols to increase the rate of implant success overall by ensuring that implants are not over or under loaded during recovery. Accordingly, there is a strong need for an instrument that has the sensitivity to noninvasively measure osseointegration in vivo. One of the objectives of the present study was to assess the performance of an instrumented percussion probe for quantitatively monitoring the osseointegration process.


2014 ◽  
Vol 15 (6) ◽  
pp. 327-332
Author(s):  
Robert Mlynski ◽  
Kristen Rak ◽  
Stefan Kaulitz ◽  
Fabian Kraus ◽  
Rudolf Hagen ◽  
...  

1960 ◽  
Vol 240 (3) ◽  
pp. 387-395 ◽  
Author(s):  
ROGER W. REED ◽  
GARDNER C. MCMILLAN ◽  
KARL PINTAR

2017 ◽  
Vol 2017 ◽  
pp. 1-3 ◽  
Author(s):  
Soham Dasgupta ◽  
Ashraf M. Aly

Ventricular septal defects (VSDs) are the most common congenital heart defects. Most of the small or moderate size (<6 mm) muscular VSDs close spontaneously within the first two years of life. The usual mechanism of spontaneous closure involves muscular tissue encroachment with superimposed fibrosis or primary fibrous tissue formation around the margins of the defect. We describe an unusual mechanism of spontaneous closure of a muscular VSD.


2021 ◽  
Vol 18 (2) ◽  
pp. 83-92
Author(s):  
K. Ts. Erdyneev ◽  
V. A. Sorokovikov ◽  
D. N. Sambuev ◽  
V. P. Saganov ◽  
P. M. Zherbakhanov

The paper is a review of the current literature data on the use of various materials and drugs for the prevention of the development of postoperative lumbar epidural fibrosis. Literature searches were performed in the Pubmed, Medline, EMBASE, Cochrane Library and eLibrary databases. The formation and growth of fibrous tissue in the epidural space, followed by tissue adhesion to the dura mater, is the leading cause of pain afferentation in the lumbar spine and/or lower extremities. Several molecular and cellular mechanisms play an important role in the pathophysiology of connective tissue formation in the epidural space. An analysis of experimental and clinical studies examining the effectiveness of various materials and drugs is presented. The authors present the current data on new therapeutic approaches to the prevention of postoperative epidural fibrosis. Topical, unresolved issues which necessitate further research on the pathophysiology of epidural fibrosis are indicated.


2020 ◽  
Vol 20 (1) ◽  
Author(s):  
Moustafa S. Magliyah ◽  
Abdulmajeed S. Al-Fakhri ◽  
Hassan A. Al-Dhibi

Abstract Background Proliferative retinopathy is an uncommon feature of Vogt Koyanagi Harada (VKH) disease which might indicate poor uveitis control in these patients. We aim to describe the clinical features and outcome of management of proliferative retinopathy in 2 patients with VKH. Case Presentation 19 and 33 years old females with VKH presented with unilateral proliferative retinopathy. Both patients had neovascularization of the optic disc (NVDs) and one patient had neovascularizations elsewhere (NVEs) and preretinal hemorrhage. Both patients had exudative retinal detachments (ERD). Systemic steroids and immunomodulatory agents were successfully used to control inflammation and achieve regression. One patient developed fibrous tissue formation at the disc area as well as an epiretinal membrane formation, for which she had pars plana vitrectomy with membrane peeling. Both patients had controlled inflammation with stable vision. Conclusions Proliferative retinopathy can present variably in VKH patients and indicates persistent inflammation which is incompletely controlled. Proper uveitis control is sufficient to achieve regression of retinal neovascularization.


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