765 The oxygen uptake efficiency slope improves after heart transplantation and predicts post-transplant maximal exercise capacity

2005 ◽  
Vol 4 (1) ◽  
pp. 173-173
Keyword(s):  
Oxygen Uptake ◽  
Heart Transplantation ◽  
Exercise Capacity ◽  
Maximal Exercise ◽  
Post Transplant ◽  
Uptake Efficiency ◽  
Oxygen Uptake Efficiency Slope ◽  
Maximal Exercise Capacity

scholarly journals Oxygen uptake efficiency slope: a reliable surrogate parameter for exercise capacity in healthy and cardiac children?

2020 ◽  
Vol 105 (12) ◽  
pp. 1167-1174
Author(s):  
Arthur Gavotto ◽  
D'arcy Vandenberghe ◽  
Hamouda Abassi ◽  
Helena Huguet ◽  
Valerie Macioce ◽  
...  
Keyword(s):  
Oxygen Uptake ◽  
Exercise Capacity ◽  
Tertiary Care ◽  
Multivariable Analysis ◽  
Female Gender ◽  
Index Number ◽  
Healthy Controls ◽  
Cross Sectional ◽  
Uptake Efficiency ◽  
Oxygen Uptake Efficiency Slope

ObjectivesCardiopulmonary exercise test (CPET) provides accurate evaluation of physical capacity and disease severity in children with congenital heart disease (CHD). However, full participation to obtain optimal measure of VO2max may be difficult. As an alternative, the oxygen uptake efficiency slope (OUES) is a reproducible and reliable parameter measured during CPET, which does not require a maximal exercise to be interpretable. This study aimed to evaluate the OUES of a large cohort of children with CHD, in comparison with healthy controls. We also intended to identify, in this specific population, the clinical and CPET variables associated with the OUES.MethodsThis cross-sectional study was carried out between November 2010 and September 2015 in two tertiary care paediatric and congenital cardiology centres.Results709 children were included (407 CHD and 302 healthy controls). The association of clinical characteristics with weight-normalised OUES (OUESkg) was studied using a multivariable analysis. The mean OUESkg was significantly lower in CHD than in healthy controls (38.6±8.5 and 43.9±8.5; p<0.001, respectively), especially in the most severe CHD. The OUESkg correlated with VO2max (r=0.85, p<0.001), with cut-off values for normal exercise capacity of 38.4 in boys and 31.0 in girls. The decrease of OUESkg was associated with increased age, increased Body Mass Index, number of cardiac catheter or surgical procedures, female gender and decreased forced vital capacity (Z-score).ConclusionThe OUES is significantly impaired in children with CHD and strongly correlates with VO2max. The OUES has the same clinical determinants as VO2max and therefore may be of interest in submaximal exercise.Trial registration numberNCT01202916.

Treatment of Anaemia in Haemodialysis Patients with Erythropoietin: Long-Term Effects on Exercise Capacity

1993 ◽  
Vol 84 (4) ◽  
pp. 441-447 ◽  
Author(s):  
Peter Báaráany ◽  
Ulla Freyschuss ◽  
Erna Pettersson ◽  
Jonas Bergström
Keyword(s):  
Oxygen Uptake ◽  
Blood Lactate ◽  
Exercise Capacity ◽  
Recombinant Human Erythropoietin ◽  
Maximal Exercise ◽  
Lactate Concentration ◽  
Blood Lactate Concentration ◽  
Human Erythropoietin ◽  
Hb Concentration ◽  
Maximal Exercise Capacity

1. The effects of correcting anaemia on exercise capacity were evaluated in 21 haemodialysis patients (aged 39 ± 12 years) before starting treatment with recombinant human erythropoietin (Hb concentration, 73 ± 10 g/l; total Hb, 59 ± 12% of expected), after correction of the anaemia to a Hb concentration of 108 ± 7 g/l and a total Hb 82 ± 10% of expected, and in 13 of the patients after 12 months on maintenance recombinant human erythropoietin treatment (Hb concentration 104 ± 14 g/l, total Hb 79 ± 17% of expected). Fifteen healthy subjects (aged 41 ± 9 years), who took no regular exercise, constituted the control group. Maximal exercise capacity was determined on a bicycle ergometer. Oxygen uptake, respiratory quotient, blood lactate concentration, heart rate and blood pressure were measured at rest and at maximal workload. 2. After 6 ± 3 months on recombinant human erythropoietin, maximal exercise capacity increased from 108 ± 27 W to 130 ± 36 W (P < 0.001) and the maximal oxygen uptake increased from 1.24 ± 0.39 litres/min to 1.50 ± 0.45 litres/min (P < 0.001). No significant changes in respiratory quotient (1.16 ± 0.13 versus 1.18 ± 0.13) and blood lactate concentration (4.0 ± 1.8 versus 3.6 ± 1.1 mmol/l) at maximal workload were observed, but the blood lactate concentration in the patients was significantly lower than that in the control subjects (6.7 ± 2.3 mmol/l, P < 0.01). After the correction of anaemia, the aerobic power was still 38% lower in the patients than in the control subjects and 17% lower than the reference values. 3. After 12 months on maintenance recombinant human erythropoietin treatment (17 ± 3 months from the start of the study), no further significant changes were observed in maximal exercise capacity (before start, 112 ± 31 W, 6 ± 3 months, 134 ± 42 W, 17 ± 3 months, 134 ± 50 W), maximal oxygen uptake (before start, 1.33 ± 0.45 litres/min; 6 ± 3 months, 1.59 ± 0.54 litres/min; 17 ± 3 months, 1.75 ± 0.78 litres/min) or blood lactate concentration (before start, 4.4 ± 1.9 mmol/l; 6 ± 3 months, 4.0 ± 1.0 mmol/l; 17 ± 3 months, 4.7 ± 2.0 mmol/l). 4. Thus, in haemodialysis patients the improvement in maximal aerobic power after the correction of anaemia persists without marked changes during long-term treatment with recombinant human erythropoietin. We did not observe any effects on exercise capacity that could be attributed to a spontaneous increase in physical activity after treatment of anaemia.

The Oxygen Uptake Efficiency Slope During Maximal Exercise Testing In Young Men With OSA

2010 ◽  
Vol 42 ◽  
pp. 336
Author(s):  
Trent A. Hargens ◽  
Stephen G. Guill ◽  
Adrian Aron ◽  
Donald Zedalis ◽  
William G. Herbert
Keyword(s):  
Oxygen Uptake ◽  
Exercise Testing ◽  
Maximal Exercise ◽  
Young Men ◽  
Uptake Efficiency ◽  
Oxygen Uptake Efficiency Slope

Validity of the Oxygen Uptake Efficiency Slope in Children With Cystic Fibrosis and Mild-To-Moderate Airflow Obstruction

2012 ◽  
Vol 24 (1) ◽  
pp. 129-141 ◽  
Author(s):  
Bart C. Bongers ◽  
Erik H.J. Hulzebos ◽  
Bert G.M. Arets ◽  
Tim Takken
Keyword(s):  
Cystic Fibrosis ◽  
Oxygen Uptake ◽  
Exercise Capacity ◽  
Ventilatory Threshold ◽  
Airflow Obstruction ◽  
Exercise Duration ◽  
Uptake Efficiency ◽  
Cardiopulmonary Exercise ◽  
Cardiopulmonary Exercise Capacity ◽  
Oxygen Uptake Efficiency Slope

Purpose: The oxygen uptake efficiency slope (OUES) has been proposed as an ‘effort-independent’ measure of cardiopulmonary exercise capacity, which could be used as an alternative measurement for peak oxygen uptake (VO2peak) in populations unable or unwilling to perform maximal exercise. The aim of the current study was to investigate the validity of the OUES in children with cystic fibrosis (CF). Methods: Exercise data of 22 children with CF and mild to moderate airflow obstruction were analyzed and compared with exercise data of 22 healthy children. The OUES was calculated using data up to three different relative exercise intensities, namely 50%, 75%, and 100% of the total exercise duration, and normalized for body surface area (BSA). Results: Only the OUES/BSA using the first 50% of the total exercise duration was significantly different between the groups. OUES/BSA values determined at different exercise intensities differed significantly within patients with CF and correlated only moderately with VO2peak and the ventilatory threshold. Conclusion: The OUES is not a valid submaximal measure of cardiopulmonary exercise capacity in children with mild to moderate CF, due to its limited distinguishing properties, its nonlinearity throughout progressive exercise, and its moderate correlation with VO2peak and the ventilatory threshold.

Oxygen Uptake Efficiency Slope, an Objective Submaximal Parameter in Evaluating Exercise Capacity in Pulmonary Thromboembolism

2016 ◽  
Vol 351 (5) ◽  
pp. 485-491 ◽  
Author(s):  
Jian Guo ◽  
Shujuan Chen ◽  
Bigyan Pudasaini ◽  
Qinhua Zhao ◽  
Wenlan Yang ◽  
...  
Keyword(s):  
Oxygen Uptake ◽  
Exercise Capacity ◽  
Pulmonary Thromboembolism ◽  
Uptake Efficiency ◽  
Oxygen Uptake Efficiency Slope

Oxygen uptake efficiency slope, a new submaximal parameter in evaluating exercise capacity in chronic heart failure patients

2005 ◽  
Vol 149 (1) ◽  
pp. 175-180 ◽  
Author(s):  
Christophe Van Laethem ◽  
Jozef Bartunek ◽  
Marc Goethals ◽  
Paul Nellens ◽  
Erik Andries ◽  
...  
Keyword(s):  
Heart Failure ◽  
Chronic Heart Failure ◽  
Oxygen Uptake ◽  
Exercise Capacity ◽  
Heart Failure Patients ◽  
Uptake Efficiency ◽  
Oxygen Uptake Efficiency Slope

The association of lung function and pulmonary vasculature volume with cardiorespiratory fitness in the community

2022 ◽  
pp. 2101821
Author(s):  
Jenna McNeill ◽  
Ariel Chernofsky ◽  
Matthew Nayor ◽  
Farbod N. Rahaghi ◽  
Raul San Jose Estepar ◽  
...  
Keyword(s):  
Lung Function ◽  
Oxygen Uptake ◽  
Blood Vessel ◽  
Exercise Capacity ◽  
Cardiorespiratory Fitness ◽  
Cardiopulmonary Exercise Testing ◽  
Pulmonary Vasculature ◽  
Uptake Efficiency ◽  
Vessel Volume ◽  
Oxygen Uptake Efficiency Slope

IntroductionCardiorespiratory fitness is not limited by pulmonary mechanical reasons in the majority of adults. However, the degree to which lung function contributes to exercise response patterns among ostensibly healthy individuals remains unclear.MethodsWe examined 2314 Framingham Heart Study participants who underwent cardiopulmonary exercise testing (CPET) and pulmonary function testing. We investigated the association of FEV1, FVC, FEV1/FVC and DLCO with the primary outcome of peak VO2, along with other CPET parameters using multivariable linear regression. Finally, we investigated the association of total and peripheral pulmonary blood vessel volume with peak VO2.ResultsWe found lower FEV1, FVC and DLCO were associated with lower peak VO2. For example, a one-liter lower FEV1 and FVC were associated with 7.1% (95% CI: 5.1%, 9.1%) and 6.0% (95% CI: 4.3%, 7.7%) lower peak VO2, respectively. By contrast, FEV1/FVC ratio was not associated with peak VO2. Lower lung function was associated with lower oxygen uptake efficiency slope oxygen pulse slope, VO2 at AT, VE at AT and breathing reserve. In addition, lower total and peripheral pulmonary blood vessel volume were associated with a lower peak VO2.ConclusionIn a large, community-based cohort of adults, we found lower FEV1, FVC and DLCO were associated with lower exercise capacity, as well as oxygen uptake efficiency slope and ventilatory efficiency. In addition, lower total and peripheral pulmonary blood vessel volume were associated with lower peak VO2. These findings underscore the importance of lung function and blood vessel volume as contributors to overall exercise capacity.

scholarly journals Body composition and maximal exercise capacity after heart transplantation

2021 ◽  
Author(s):  
Julien Regamey ◽  
Pierre Monney ◽  
Patrick Yerly ◽  
Lucie Favre ◽  
Matthias Kirsch ◽  
...  
Keyword(s):  
Body Composition ◽  
Heart Transplantation ◽  
Exercise Capacity ◽  
Maximal Exercise ◽  
Maximal Exercise Capacity
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