Validity of the Oxygen Uptake Efficiency Slope in Children With Cystic Fibrosis and Mild-To-Moderate Airflow Obstruction

2012 ◽  
Vol 24 (1) ◽  
pp. 129-141 ◽  
Author(s):  
Bart C. Bongers ◽  
Erik H.J. Hulzebos ◽  
Bert G.M. Arets ◽  
Tim Takken
Keyword(s):  
Cystic Fibrosis ◽  
Oxygen Uptake ◽  
Exercise Capacity ◽  
Ventilatory Threshold ◽  
Airflow Obstruction ◽  
Exercise Duration ◽  
Uptake Efficiency ◽  
Cardiopulmonary Exercise ◽  
Cardiopulmonary Exercise Capacity ◽  
Oxygen Uptake Efficiency Slope

Purpose: The oxygen uptake efficiency slope (OUES) has been proposed as an ‘effort-independent’ measure of cardiopulmonary exercise capacity, which could be used as an alternative measurement for peak oxygen uptake (VO2peak) in populations unable or unwilling to perform maximal exercise. The aim of the current study was to investigate the validity of the OUES in children with cystic fibrosis (CF). Methods: Exercise data of 22 children with CF and mild to moderate airflow obstruction were analyzed and compared with exercise data of 22 healthy children. The OUES was calculated using data up to three different relative exercise intensities, namely 50%, 75%, and 100% of the total exercise duration, and normalized for body surface area (BSA). Results: Only the OUES/BSA using the first 50% of the total exercise duration was significantly different between the groups. OUES/BSA values determined at different exercise intensities differed significantly within patients with CF and correlated only moderately with VO2peak and the ventilatory threshold. Conclusion: The OUES is not a valid submaximal measure of cardiopulmonary exercise capacity in children with mild to moderate CF, due to its limited distinguishing properties, its nonlinearity throughout progressive exercise, and its moderate correlation with VO2peak and the ventilatory threshold.

scholarly journals Oxygen uptake efficiency slope: a reliable surrogate parameter for exercise capacity in healthy and cardiac children?

2020 ◽  
Vol 105 (12) ◽  
pp. 1167-1174
Author(s):  
Arthur Gavotto ◽  
D'arcy Vandenberghe ◽  
Hamouda Abassi ◽  
Helena Huguet ◽  
Valerie Macioce ◽  
...  
Keyword(s):  
Oxygen Uptake ◽  
Exercise Capacity ◽  
Tertiary Care ◽  
Multivariable Analysis ◽  
Female Gender ◽  
Index Number ◽  
Healthy Controls ◽  
Cross Sectional ◽  
Uptake Efficiency ◽  
Oxygen Uptake Efficiency Slope

ObjectivesCardiopulmonary exercise test (CPET) provides accurate evaluation of physical capacity and disease severity in children with congenital heart disease (CHD). However, full participation to obtain optimal measure of VO2max may be difficult. As an alternative, the oxygen uptake efficiency slope (OUES) is a reproducible and reliable parameter measured during CPET, which does not require a maximal exercise to be interpretable. This study aimed to evaluate the OUES of a large cohort of children with CHD, in comparison with healthy controls. We also intended to identify, in this specific population, the clinical and CPET variables associated with the OUES.MethodsThis cross-sectional study was carried out between November 2010 and September 2015 in two tertiary care paediatric and congenital cardiology centres.Results709 children were included (407 CHD and 302 healthy controls). The association of clinical characteristics with weight-normalised OUES (OUESkg) was studied using a multivariable analysis. The mean OUESkg was significantly lower in CHD than in healthy controls (38.6±8.5 and 43.9±8.5; p<0.001, respectively), especially in the most severe CHD. The OUESkg correlated with VO2max (r=0.85, p<0.001), with cut-off values for normal exercise capacity of 38.4 in boys and 31.0 in girls. The decrease of OUESkg was associated with increased age, increased Body Mass Index, number of cardiac catheter or surgical procedures, female gender and decreased forced vital capacity (Z-score).ConclusionThe OUES is significantly impaired in children with CHD and strongly correlates with VO2max. The OUES has the same clinical determinants as VO2max and therefore may be of interest in submaximal exercise.Trial registration numberNCT01202916.

Intratest reliability and test–retest reproducibility of the oxygen uptake efficiency slope in healthy participants

2009 ◽  
Vol 16 (4) ◽  
pp. 493-498 ◽  
Author(s):  
Christophe Van Laethem ◽  
Johan De Sutter ◽  
Wim Peersman ◽  
Patrick Calders
Keyword(s):  
Carbon Dioxide ◽  
Oxygen Uptake ◽  
Minute Ventilation ◽  
Exercise Duration ◽  
Peak Oxygen Uptake ◽  
Exercise Tests ◽  
Uptake Efficiency ◽  
Carbon Dioxide Output ◽  
Oxygen Uptake Efficiency Slope ◽  
Healthy Participants

Background The oxygen uptake efficiency slope (OUES) is a newer ventilatory exercise parameter, used in the evaluation of healthy participants and patients with cardiovascular disease. However, few data about the reliability and reproducibility of OUES are available. Our study assessed intratest reliability and test-retest reproducibility of OUES in healthy participants. Design and methods Eighteen participants (age 28 ± 6 years, BMI 22.1 ± 1.9 kg/m2, 10 men) performed two identical maximal exercise tests on a bicycle ergometer. To assess test-retest reproducibility, we performed Bland-Altman analysis and calculated the coefficient of repeatability of the main ventilatory variables. Results OUES remained stable during the second part of the exercise test. Mean values varied 2.4 ± 4.0% between OUES calculated at 70% (OUES70) and at 100% of exercise duration. Mean variation decreased to 1.4 ± 2.3% when OUES was calculated at 90% of exercise duration (OUES90). The Bland-Altman 95% limits of agreement for OUES90 were +3 and –6%, those for OUES70 were +11 and –8%. The coefficient of repeatability for OUES was 597 ml/min or 18.7% of the average value of repeated OUES measurements. These results were similar to those of peak oxygen uptake and minute ventilation/carbon dioxide output. However, the test-retest reproducibility for submaximal-derived values of OUES was lower, as we noted higher coefficients of repeatability for OUES90 and OUES70, increasing up to 27% of the average of repeated values. Conclusion OUES shows excellent intratest reliability and has a test-retest reproducibility that is similar to that of peak oxygen uptake and minute ventilation/carbon dioxide output slope. However, its reproducibility becomes higher when it is calculated from increasing levels of achieved exercise intensity.

Abstract 2424: Improvement Of Cardiopulmonary Exercise Capacity In Patients With Chronic Post-infarction Heart Failure (CHF) After Intracoronary Infusion Of Bone Marrow-derived Progenitor Cells (BMC)

Circulation ◽  
2008 ◽  
Vol 118 (suppl_18) ◽  
Author(s):  
Joerg Honold ◽  
Lenka Geiger ◽  
Ulrich Fischer-Rasokat ◽  
Birgit Assmus ◽  
Volker Schaechinger ◽  
...  
Keyword(s):  
Heart Failure ◽  
Oxygen Uptake ◽  
Exercise Capacity ◽  
Serum Levels ◽  
Left Ventricular ◽  
Left Ventricular Ejection ◽  
Ventricular Ejection Fraction ◽  
Cardiopulmonary Exercise ◽  
Cardiopulmonary Exercise Capacity ◽  
Peak Vo2

Intracoronary (i.c.) infusion of BMC in patients (pts.) with CHF is associated with improvements in left ventricular ejection fraction (LVEF) and reduction of NT-proBNP serum-levels, especially in pts. with more severe heart failure. However, ist is unknown whether the modest improvements in cardiac function translate into an increase in cardiopulmonary exercise capacity. A total of 52 CHF-pts. performed cardiopulmonary exercise tests (CPET) according to a modified Bruce protocol before and 3 months after i.c. infusion of BMC into the infarct-related artery. Anaerobic threshold (AT) was determined by the v-slope method. Overall, pts. were 58±12 years old with a moderately impaired LVEF (mean 42±11%) and a median NYHA-class 2±0.75. NT-proBNP-serum levels were elevated (1007±154 pmol/ml). All pts. received chronic optimized medical therapy with betablockers, ACE-inhibitors and combined diuretics, which was kept constant during the study duration. Initial CPET revealed reduced peak oxygen uptake (peak VO2: 14.0 ml/min/kg), maximal oxygen Pulse (O2Pmax: 11.4 ml/beat) and oxygen uptake at AT (VO2AT: 10.9 ml/min/kg), whereas CO2-equivalents (EqCO2) were elevated (29.7). 3 months after therapy, repeated CPET showed an increase in peak VO2 (14.0±3.9 to 15.3±4.3 ml/min/kg, p=0.07), whereas VO2 AT (10.8±2.5 to 10.8±2.5 ml/min/kg, p= n.s.), O2Pmax (11.2 ± 3.1 to 12.0±3.3 ml/beat, p= n.s.) or EqCO2 (29.7±6.4 to 29.8±6.8, p= n.s.) remained unchanged. However, after dichotomizating the patient cohort according to the median of VO2max at baseline, pts. with lower initial VO2max showed a significant improvement in VO2max (12.8±1.5 to 13.5±2.7ml/min/kg, p= 0.03) and an improvement in VO2AT (9.1±1.8 to 9.5±2.2 ml/min/kg, p= ns), as well as a reduction of EqCO2 (34.7±7.1 to 33.8±8.0, p= ns). In contrast, pts. with initial VO2max > median did not show any significant improvements. These findings indicate that intracoronary BMC-therapy improves exercise capacity in CHF-patients with more advanced heart failure. Therefore, cardiopulmonary exercise testing might help to identify pts. more likely to derive functional benefit from intracoronary BMC administration.

Oxygen Uptake Efficiency Slope in Healthy Children

2010 ◽  
Vol 22 (3) ◽  
pp. 431-441 ◽  
Author(s):  
Moniek Akkerman ◽  
Marco van Brussel ◽  
Bart C. Bongers ◽  
Erik H.J. Hulzebos ◽  
Paul J.M Helders ◽  
...  
Keyword(s):  
Oxygen Uptake ◽  
Ventilatory Threshold ◽  
Pediatric Population ◽  
Fat Free Mass ◽  
Healthy Children ◽  
Bicycle Ergometry ◽  
Exercise Tests ◽  
Uptake Efficiency ◽  
Cardiorespiratory Function ◽  
Oxygen Uptake Efficiency Slope

The objective of this study was to investigate the characteristics of the submaximal Oxygen Uptake Efficiency Slope (OUES) in a healthy pediatric population. Bicycle ergometry exercise tests with gas-analyses were performed in 46 healthy children aged 7–17 years. Maximal OUES, submaximal OUES, V̇O2peak, VEpeak, and ventilatory threshold (VT) were determined. The submaximal OUES correlated highly with V̇O2peak, VEpeak, and VT. Strong correlations were found with basic anthropometric variables. The submaximal OUES could provide an objective, independent measure of cardiorespiratory function in children, reflecting efficiency of ventilation. We recommend expressing OUES values relative to Body Surface Area (BSA) or Fat Free Mass (FFM).

scholarly journals The oxygen uptake efficiency slope is not a valid surrogate of aerobic fitness in cystic fibrosis

2017 ◽  
Vol 53 (1) ◽  
pp. 36-42 ◽  
Author(s):  
Craig A. Williams ◽  
Owen W. Tomlinson ◽  
Lucy V. Chubbock ◽  
Daniel Stevens ◽  
Zoe L. Saynor ◽  
...  
Keyword(s):  
Cystic Fibrosis ◽  
Oxygen Uptake ◽  
Aerobic Fitness ◽  
Uptake Efficiency ◽  
Oxygen Uptake Efficiency Slope

Non-linear is not superior to linear aerobic training periodization in coronary heart disease patients

2019 ◽  
Vol 27 (16) ◽  
pp. 1691-1698
Author(s):  
Maxime Boidin ◽  
Lukas-Daniel Trachsel ◽  
Anil Nigam ◽  
Martin Juneau ◽  
Jonathan Tremblay ◽  
...  
Keyword(s):  
Coronary Heart Disease ◽  
Heart Disease ◽  
Oxygen Uptake ◽  
Aerobic Training ◽  
Uptake Efficiency ◽  
Cardiopulmonary Exercise ◽  
Supervised Exercise ◽  
Non Linear ◽  
Oxygen Uptake Efficiency Slope ◽  
Training Protocols

Background We aimed to compare: (1) two different periodized aerobic training protocols (linear (LP) versus non-linear (NLP)) on the cardiopulmonary exercise response in patients with coronary heart disease; (2) the proportion of responders between both training protocols. Design A randomized controlled trial. Methods A total of 39 coronary heart disease patients completed either LP ( n = 20, 65 ± 10 years) or NLP ( n = 19, 66 ± 5 years). All patients completed a cardiopulmonary exercise testing with gas exchange measurements. Patients underwent a 12-week supervised exercise program including an isoenergetic aerobic periodized training and a similar resistance training program, 3 times/week. Weekly energy expenditure was constantly increased in the LP group for the aerobic training, while it was deeply increased and intercepted with a recovery week each fourth week in the NLP group. Peak oxygen uptake (peak V̇O2), oxygen uptake efficiency slope, ventilatory efficiency slope (V̇E/V̇CO2 slope), V̇O2 at the first (VT1) and second (VT2) ventilatory thresholds, and oxygen pulse (O2 pulse) were measured. Responders were determined according the median value of the Δpeak V̇O2 (mL.min−1.kg−1). Results We found similar improvement for peak V̇O2 (LP: +8.1%, NLP: +5.3%, interaction: p = 0.37; time: p < 0.001) and for oxygen uptake efficiency slope, VT1, VT2 and O2 pulse in both groups (interaction: p > 0.05; time: p < 0.05) with a greater effect size in the LP group. The proportion of non-, low and high responders was similar between groups ( p = 0.29). Conclusion In contrast to the athletes, more variation (NLP) does not seem necessary for greater cardiopulmonary adaptations in coronary heart disease patients.

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