scholarly journals In vivo antioxidant effect of aqueous root bark, stem bark and leaves extracts of Vitex doniana in CCl4 induced liver damage rats

2013 ◽  
Vol 3 (5) ◽  
pp. 395-400 ◽  
Author(s):  
Kadejo Olubukola Adetoro ◽  
James Dorcas Bolanle ◽  
Sallau Balarebe Abdullahi ◽  
Ozigi Abdulrahaman Ahmed
Keyword(s):  
Liver Damage ◽  
Stem Bark ◽  
Antioxidant Effect ◽  
Root Bark ◽  
Vitex Doniana ◽  
In Vivo Antioxidant Effect

Polyphenolic profiles and the in vivo antioxidant effect of nipa vinegar on paracetamol induced liver damage

RSC Advances ◽  
2016 ◽  
Vol 6 (68) ◽  
pp. 63304-63313 ◽  
Author(s):  
Boon Kee Beh ◽  
Nurul Elyani Mohamad ◽  
Swee Keong Yeap ◽  
Kian Lam Lim ◽  
Wan Yong Ho ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Gallic Acid ◽  
Liver Damage ◽  
Protocatechuic Acid ◽  
Antioxidant Effect ◽  
In Vivo Antioxidant Effect ◽  
And Oxidative Stress

Nipa vinegar, which is rich in gallic acid and protocatechuic acid, has reverted the paracetamol-induced liver damage in mice by reduction of inflammation and oxidative stress.

scholarly journals Hepatocurative potential of Vitex doniana root bark, stem bark and leaves extracts against CCl4–induced liver damage in rats

2014 ◽  
Vol 4 (6) ◽  
pp. 480-485 ◽  
Author(s):  
James Dorcas Bolanle ◽  
Kadejo Olubukola Adetoro ◽  
Sallau Abdullahi Balarabe ◽  
Owolabi Olumuyiwa Adeyemi
Keyword(s):  
Liver Damage ◽  
Stem Bark ◽  
Root Bark ◽  
Vitex Doniana

In vivo Antioxidant and Hepato-Protective Properties of Stem Bark Methanol Extract of Vitex doniana

2020 ◽  
Vol 4 (1) ◽  
pp. 36-40
Author(s):  
Simon C. Mailafiya ◽  
Sherifat O. Kolawole ◽  
Abdulazeez K. Adeniyi ◽  
Bala A. Muhammed ◽  
Abdulfatai Ismail ◽  
...  
Keyword(s):  
Liver Damage ◽  
Methanol Extract ◽  
Stem Bark ◽  
Negative Control ◽  
Albino Rats ◽  
Albumin Concentration ◽  
Adult Rats ◽  
Control Drug ◽  
Vitex Doniana

Abstract The harmful effects that accompany the use of orthodox antioxidant medicine have necessitated the hunt for inherent antioxidants from plants extracts. In the present study, the in vivo antioxidant and hepato-protective activities of Vitex doniana against carbon tetrachloride (CCl4) induced liver damage in albino rats were investigated. The hepato-protective activities of the methanol extract of Vitex doniana stem bark were compared with Silymarin, a known hepatoprotective drug. Twenty-five (25) male albino adult rats were grouped into five (5) each. Group 1 and 2 was used as the normal and negative control respectively. Group 3-5 were treated with 200 mg/kg, 400 mg/kg methanol extract of Vitex doniana stem bark and 100 mg/kg Silymarin respectively. Results indicated that elevated levels of serum ALT, AST and ALB, and reduced serum SOD, GST and CAT in CCl4-hepatotoxic rats was an evidence of impairment in liver function. Administration of methanol extract of Vitex doniana stem bark (200 and 400 mg/kg body weight) and standard control drug Silymarin (100 mg/kg) have no significant (P>0.05) effect on CCl4- induced elevations of the ALT and AST levels while the reduction in albumin concentration, total proteins, SOD, GST and CAT due to CCl4 was reversed. In conclusion, Vitex doniana exhibited significant antioxidant and hepatoprotective properties in CCL4 induced liver damage in rat, and thus could be used and incorporated in the development of new and effective antioxidant drugs.

scholarly journals In vivo and In vitro Antioxidant Activities of Aqueous and Ethanol Stem Bark Extracts of Vitex doniana on Doxorubicin-induced Oxidative Stress in Rats

2021 ◽  
pp. 44-55
Author(s):  
Mohammed Aliyu Sulaiman ◽  
Daniel Dahiru ◽  
Mohammed Auwal Ibrahim ◽  
Ahmed Ibrahim Hayatu
Keyword(s):  
Oxidative Stress ◽  
Antioxidant Activities ◽  
Ischemia Reperfusion ◽  
Oral Treatment ◽  
Stem Bark ◽  
Albino Rats ◽  
Associated Diseases ◽  
Vitex Doniana

Background: Oxidative stress is involved in the pathogenesis of hypertension, myocardial ischemia-reperfusion injury, atherosclerosis, muscular dystrophy, aging and other associated diseases. Vitex doniana is used in Adamawa, northern Nigeria to treat oxidative stress associated diseases. However, the antioxidative effects of the plant have not been scientifically examined in oxidative stress experimental animal models. The aim of this study is to investigate the in vitro and in vivo antioxidant activities of aqueous and ethanol stem bark extracts of Vitex doniana in oxidative stress model of rats. Methods: The study used 35 adult albino rats weighing 175 ± 25 g, of which 30 were induced with oxidative stress by intraperitoneal injection of doxorubicin (10 mg/kg) for three consecutive days. Animals were treated by oral administration of silymarin (100 mg/kg) and Vitex doniana aqueous or ethanol extract (100 mg/kg and 200 mg/kg) for 14 consecutive days before they were sacrificed on the 15th day and blood was analyzed for biochemical indices of oxidative stress. Results: The results of the phytochemistry showed the presence of alkaloids, tannins, flavonoids, steroids, phenols, saponins, terpenoids, glycosides: and total flavonoids (52.70 ± 1.60 mg/ml and 75.40 ± 0.80 mg/ml), total phenols (21.45 ± 1.54 mg/ml and 26.50 ± 1.22 mg/ml) for aqueous and ethanol stem bark extracts respectively. The extracts scavenged DPPH radical, reduced Fe3+ and inhibited lipid peroxidation. Doxorubicin significantly (p<0.05) lowered the levels of SOD, CAT, GR and TAS and significantly (p<0.05) but, increased the level of LPO. Oral treatment with Vitex doniana extracts significantly (p<0.05) increased the activities of CAT, GR, SOD and TAS while LPO was significantly (p<0.05) lowered. Vitex doniana stem bark extracts significantly (p<0.05) improved the biochemical derangements observed in the induced untreated animals in comparable manner to that of Silymarin. Conclusion: The present study provides the scientific rationale for the use of Vitex doniana stem bark in traditional medicine and has a viable antioxidative capacity both in vitro and in vivo.

Improvement of stability and in vivo antioxidant effect of human glutathione peroxidase mutant by PEGylation

2021 ◽  
Vol 609 ◽  
pp. 121152
Author(s):  
Yanwei Wang ◽  
Shaopeng Niu ◽  
Bozhao Li ◽  
Qi Yan ◽  
Yiding Zhao ◽  
...  
Keyword(s):  
Glutathione Peroxidase ◽  
Antioxidant Effect ◽  
In Vivo Antioxidant Effect

scholarly journals Extension of life-span using a RNAi model and in vivo antioxidant effect of Opuntia fruit extracts and pure betalains in Caenorhabditis elegans

2019 ◽  
Vol 274 ◽  
pp. 840-847 ◽  
Author(s):  
M. Alejandra Guerrero-Rubio ◽  
Samanta Hernández-García ◽  
Francisco García-Carmona ◽  
Fernando Gandía-Herrero
Keyword(s):  
Caenorhabditis Elegans ◽  
Life Span ◽  
Antioxidant Effect ◽  
Fruit Extracts ◽  
In Vivo Antioxidant Effect

In vivo antioxidant effect of aqueous and etheric coriander (Coriandrum sativum L.) extracts

2003 ◽  
Vol 105 (9) ◽  
pp. 483-487 ◽  
Author(s):  
Enayde de Almeida Melo ◽  
Francisca Martins Bion ◽  
Jorge Mancini Filho ◽  
Nonete Barbosa Guerra
Keyword(s):  
Antioxidant Effect ◽  
Coriandrum Sativum ◽  
In Vivo Antioxidant Effect
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