Tympanic plethysmography in glomus jugulare tumours

1981 ◽  
Vol 95 (6) ◽  
pp. 589-595
Author(s):  
Sayed Tewfik
Keyword(s):  
Pressure Transducer ◽  
Diagnostic Technique ◽  
X Rays ◽  
Axial Tomography ◽  
Non Invasive ◽  
Glomus Jugulare ◽  
Diagnostic Technology ◽  
Carotid Aneurysms ◽  
Pressure Changes ◽  
Degree Of Extension

SummaryTympanic plethysmography is a simple non-invasive diagnostic technique which is used to differentiate between intra-temporal carotid aneurysms and glomus jugulare tumours and to predict the degree of extension of the tumour. It is performed by the indirect recording of volume pressure changes of pulsating tympanic masses using a pressure transducer. The volume pressure change of the pulsating mass is transmitted to the pressure transducer through a saline-filled system.Medical technology has undergone considerable progress with the introduction of new techniques in medical diagnosis less harmful to the patient and with a reduced risk of complications. The collaboration of doctors, scientists and bioengineers has resulted in the evolution of such changes, thereby trying to replace the more aggressive or invasive diagnostic techniques. The ideal diagnostic technology is one without pain, harm or complications to the patient.Medical diagnostic technology may be classified as invasive or noninvasive. Non-invasive diagnostic technology is either active, using an external source of energy such as ultrasound (ultrasonography) or a small dose of X-rays, as in computerized axial tomography; or passive, using the energy emitted by human structures, as in plethysmography.Plethysmography is the recording of volume pressure changes. Oculoplethysmography is used to monitor extracranial occlusive carotid disease (Kartchner and McRae, 1973). The use of sound energy as an internal energy emitted by the human body has proved effective as a passive, non-invasive diagnostic technique (Tewfik, 1976, 1977).Volume pressure changes of intra-temporal carotid aneurysms have been recorded, using a pressure transducer (Tewfik, 1974).In this article the volume pressure changes of glomus jugulare tumours have been recorded and the findings compared with those obtained, and previously published, for intra-temporal carotid aneurysms. Volume pressure changes of pulsating tympanic masses may be called tympanic plethysmography. A trial of this simple non-invasive diagnostic technique for differentiating pulsating tympanic masses is here reported, together with an assessment of the technique in its ability to predict the degree of extension of glomus jugulare tumours.

Phonocephalography: a simple, low-cost non-invasive diagnostic technique

1983 ◽  
Vol 97 (12) ◽  
pp. 1133-1138 ◽  
Author(s):  
Sayed Tewfik
Keyword(s):  
Low Cost ◽  
Diagnostic Technique ◽  
Aortic Lesion ◽  
Non Invasive ◽  
Glomus Jugulare ◽  
Glomus Jugulare Tumour

AbstractThis article presents the phonocephalographic data reported in one case of glomus jugulare tumour, representing local haemodynamic disturbances; and one case with an aortic lesion with pulsating tinnitus, representing systemic haemodynamic disturbances.

scholarly journals AB0945 CONTRIBUTION OF MICROBIOLOGICAL AND ANATOMOPATHOLOGICAL EXAMINATIONS IN THE DIAGNOSIS OF SPONTANEOUS PYOGENIC SPONDYLODISCITIS IN ADULTS

2020 ◽  
Vol 79 (Suppl 1) ◽  
pp. 1771.3-1771
Author(s):  
I. Mahmoud ◽  
M. Moalla ◽  
A. Ben Tekaya ◽  
S. Bouden ◽  
R. Tekaya ◽  
...  
Keyword(s):  
Histopathological Examination ◽  
Klebsiella Oxytoca ◽  
Rare Condition ◽  
Blood Cultures ◽  
X Rays ◽  
Skin Sample ◽  
Bacteriological Study ◽  
Non Invasive ◽  
Pyogenic Spondylodiscitis ◽  
Serious Infection

Background:Pyogenic spondylodiscitis (SPD) is a serious infection of an intervertebral disc and/or adjacent vertebrae, that remains a topical problem in rheumatological practice. Early diagnosis and treatment are the only guarantees of a favorable outcome. Clinicians must strive to isolate the responsible bacteria in order to adapt the treatment, and thus reduce the risk of resistance and complications due to SPD itself, but also to the multiplication of probabilistic treatments.Objectives:Our aim was to study the contribution of the different microbiological and anatomopathological examinations in the diagnosis of pyogenic SPD.Methods:It was a descriptive study in a single rheumatology department. Data were collected retrospectively from observations of patients hospitalized in the past 20 years who have been diagnosed with pyogenic SPD. We excluded cases of tuberculous and brucellar SPD from our study because of their completely different histological and microbiological profiles.Results:Twenty-two cases of pyogenic SPD were collected (14M/ 8F). The mean age of the population was 55.9 years [29,80]. A bacteriological survey including at least one cytobacteriological examination of the urine (CBEU), chest X-rays and blood cultures allowed the identification of the bacteria in 16 cases (73%). The most common site were bacteria was identified was blood culture in 7 cases, skin sample and urine collection in 2 cases each. Disco-vertebral puncture and biopsy (DVPB) was performed in 19 patients when there was no bacteria identification and/or when diagnosis of infectious SPD persisted doubtful. On histopathological examination, were described: an infiltrate and/or inflammatory changes without specificity signs in 7 patients and an appearance of chronic pyogenic SPD very likely in 12 patients. Bacteriological study of DVPB fluid or paravertebral abscesses sample helped to isolate bacteria in 4 patients. DVPB or abscesses puncture were contributing by histological and/or bacteriological examination in 12 patients (63%).Infecting bacteria was identified in 14 patients (64%). Gram-negative bacilli (GNB) and staphylococcus aureus were the most frequent germs (7 cases each) including 2 cases of co-infection. GNBs were represented by: Escherichia Coli and Enterobacter Cloacae in 2 cases each, Proteus Mirabilis, Serratia Marcescens and Klebsiella oxytoca in 1 case each. Clostridium clostridioforme and Lactococcus cremoris were isolated in 1 case each. For patients whose etiological investigation remained negative, SPD diagnosis was retained based on imaging (MRI) guided by anamnestic, clinico-biological and histopathological arguments.Conclusion:SPD is a rare condition that needs to be treated rapidly. Once the diagnosis is suspected, bacteria must be isolated before starting any antibiotic therapy. Simple and non-invasive exams as blood cultures, CBUE and chest rays, should be undertaken first. In fact, these simple exams allowed a germ identification in 73% cases in our study. If doubt persist, DVPB could be contributive to the diagnosis.References:NoneDisclosure of Interests:None declared

scholarly journals Current status of ctDNA in precision oncology for hepatocellular carcinoma

2021 ◽  
Vol 40 (1) ◽  
Author(s):  
Yan Li ◽  
Yuanyuan Zheng ◽  
Liwei Wu ◽  
Jingjing Li ◽  
Jie Ji ◽  
...  
Keyword(s):  
Hepatocellular Carcinoma ◽  
Cancer Progression ◽  
Diagnostic Technique ◽  
Response Assessment ◽  
Selection Response ◽  
Circulating Tumor Dna ◽  
Current Status ◽  
Precision Oncology ◽  
Tumor Biopsy ◽  
Non Invasive

AbstractThe conventional method used to obtain a tumor biopsy for hepatocellular carcinoma (HCC) is invasive and does not evaluate dynamic cancer progression or assess tumor heterogeneity. It is thus imperative to create a novel non-invasive diagnostic technique for improvement in cancer screening, diagnosis, treatment selection, response assessment, and predicting prognosis for HCC. Circulating tumor DNA (ctDNA) is a non-invasive liquid biopsy method that reveals cancer-specific genetic and epigenetic aberrations. Owing to the development of technology in next-generation sequencing and PCR-based assays, the detection and quantification of ctDNA have greatly improved. In this publication, we provide an overview of current technologies used to detect ctDNA, the ctDNA markers utilized, and recent advances regarding the multiple clinical applications in the field of precision medicine for HCC.

Paleopathological study of the Egyptian mummies collected in Italy: the Anubis project

1970 ◽  
Vol 80 (1) ◽  
Author(s):  
Rosalba Ciranni ◽  
Donata Pangoli ◽  
Valentina Giuffra ◽  
DAvide Caramella ◽  
Edda Bresciani ◽  
...  
Keyword(s):  
X Rays ◽  
Axial Tomography ◽  
Technical Problems ◽  
Histological Studies ◽  
Computed Axial Tomography ◽  
The University ◽  
First Time

Eighty-five Egyptian mummies belonging to different dynastic periods and collected in a number of Italian museums, have been censed and submitted for paleopathological research. In most cases the presence of bandages required the application of X- rays and computed axial tomography (CAT). Fifty-two mummies have been studied in situ with Xrays; twelve with CAT scanning. Technical problems kept us from investigating eleven of the censed mummies. In a few cases it was possible to perform autopsies, endoscopy, or histological studies. The mummies submitted for X- rays were divided into two groups: The first group thirty-six mummies studied by the team of Paleopathology-Egyptology of the University of Pisa were studied for the first time. The second group was composed of twenty-six mummies studied elsewhere in Italy. Those results also have been included in the Anubi Project database.

scholarly journals Role of transvaginal sonography in various gynecological disorders

2017 ◽  
Vol 6 (7) ◽  
pp. 3138
Author(s):  
Pooja J. Mise ◽  
Sangamesh J. Mise ◽  
Aditya Mise ◽  
Margol Siddappa
Keyword(s):  
Diagnostic Accuracy ◽  
Inflammatory Diseases ◽  
Diagnostic Technique ◽  
Abdominal Hysterectomy ◽  
Transvaginal Sonography ◽  
Dysfunctional Uterine Bleeding ◽  
Non Invasive ◽  
Gynecological Disorders ◽  
Dilatation And Curettage

Background: Transvaginal sonography (TVS) is a new diagnostic technique used for the evaluation of the female pelvis. The objective of the present study was to study the role of TVS and to assess the diagnostic accuracy in gynecological disorders.Methods: Total number of 100 patients attending OPDs with various complaints was selected by random technique of the study.  All the patients have informed consent and thorough clinical examination including general, systemic and pelvic examination was conducted after taking a detailed history then the patients underwent TVS followed by one of the procedures like fractional curettage, dilatation and curettage and abdominal hysterectomy (with or without conservation of ovaries) or conservative management with regular follow up.Results: The sensitivity of TVS in diagnosing dysfunctional uterine bleeding (DUB) and pelvic inflammatory diseases (PID) was 100% and specificity was 85.1% and 95% respectively. For fibroids and ovarian mass diagnosis, sensitivity was 68.9% and 80.9% respectively and specificity was 100%. Diagnostic accuracy of clinical diagnosis was 70.0% whereas TVS had 94.0% of diagnostic accuracy in diagnosing various gynecological disorders.Conclusions: The final outcome is that TVS examination is an important non-invasive investigation, can be used as important diagnostic method in various gynecological disorders as it has got a high diagnostic accuracy.

Identification of Compensatory Arterial Dynamics in Swine Using a Non-Invasive Sensor for Local Vascular Resistance

2018 ◽  
Author(s):  
Lu Wang ◽  
Sardar Ansari ◽  
Kevin R. Ward ◽  
Kayvan Najarian ◽  
Kenn R. Oldham
Keyword(s):  
Cardiovascular System ◽  
Vascular Resistance ◽  
Systemic Circulation ◽  
Test Subject ◽  
Loop Model ◽  
Peripheral Vascular ◽  
Dynamics Model ◽  
Non Invasive ◽  
Peripheral Arterial ◽  
Pressure Changes

Autoregulatory dynamics of the cardiovascular system play an important role in maintaining oxygenated blood transportation throughout the human body. In this work, a feedback dynamics model of the cardiovascular system with respect to heartrate and peripheral vascular resistance effects on longer-term blood pressure changes in the systemic circulation is presented. The model is identified from data taken from a swine test subject, instrumented in part with a wearable, non-invasive sensor for estimating peripheral arterial radius. Comparative simulations for the open and close loop model highlight significantly changed hemodynamics after hemorrhage.

scholarly journals Dermoscopy and Trichoscopy in Dermatomyositis—A Cross-Sectional Study

2022 ◽  
Vol 11 (2) ◽  
pp. 375
Author(s):  
Magdalena Żychowska ◽  
Adam Reich
Keyword(s):  
Diagnostic Technique ◽  
Skin Lesions ◽  
Cross Sectional Study ◽  
Cutaneous Lesions ◽  
Cross Sectional ◽  
Cutaneous Manifestations ◽  
Non Invasive ◽  
Inflammatory Dermatoses ◽  
Curved Vessels ◽  
Established Role

Background: (Video)dermoscopy is a non-invasive diagnostic technique that has a well-established role in dermatooncology. In recent years, this method has also been increasingly used in the assessment of inflammatory dermatoses. So far, little is known about the (video)dermoscopic features of dermatomyositis (DM). Methods: Consecutive patients with DM were included in the study and videodermoscopic assessments of the nailfolds, scalp, and active skin lesions were performed. Results: Fifteen patients with DM (10 women and 5 men) were included. Capillaroscopy showed elongated capillaries (90.9%), avascular areas (81.8%), disorganized vessel architecture (81.8%), tortuous capillaries (72.7%), dilated capillaries (72.7%), and hemorrhages (72.7%). The trichoscopic findings included linear branched vessels (80.0%), linear vessels (60.0%), linear curved vessels (53.3%), perifollicular pigmentation (40.0%), perifollicular erythema (33.3%), scaling (20.0%), white (20.0%) or yellow (20%) interfollicular scales, and white (20.0%) or pinkish (13.3%) structureless areas. Polymorphic vessels of an unspecific distribution and white or pink structureless areas were frequently observed under dermoscopy in cutaneous manifestations of DM, including Gottron’s papules and Gottron’s sign. Conclusions: Dermoscopy of the nailfolds (capillaroscopy), scalp (tricoscopy), and active cutaneous lesions may be of value in the preliminary diagnosis of DM.

Ultrasound in paediatric cardiology — state of the art

2011 ◽  
Author(s):  
Luc L. Mertens
Keyword(s):  
Heart Disease ◽  
Cardiac Catheterization ◽  
Clinical Skills ◽  
Diagnostic Technique ◽  
Paediatric Cardiology ◽  
Non Invasive ◽  
Doppler Data ◽  
Echocardiographic Examination ◽  
Cardiac Evaluation ◽  
Ultrasound Technology

The development of ultrasound technology to visualize cardiac structures, based on the pioneering work by Edler and Hertz at the University of Lund in Sweden, has literally created a revolution in the field of paediatric cardiology. Before the era of cardiac catheterization and echocardiography the diagnosis of congenital heart disease was mainly based on combining physical findings, cardiac auscultation, electrocardiogram (ECG), and chest X-ray. This was largely based on the work by Helen B. Taussig at John Hopkins in the 1930s who established the field of clinical paediatric cardiology by integrating pathology knowledge with clinical findings. Diagnosis at that time was based on clinical skills and was more an art than science. The introduction of paediatric cardiac surgery in the 1950s was made possible due to the simultaneous development of cardiac catheterization and angiography which allowed an accurate description of the different cardiac lesions and the associated haemodynamics prior to surgery. For a long period catheterization was the diagnostic gold standard and all surgical patients underwent an invasive cardiac evaluation. In the 1970s, echocardiography was developed as a clinical tool and due to its non-invasive nature, was introduced quickly in paediatric cardiology. As anatomical diagnosis is challenging by M-mode echocardiography, it was really the development of two-dimensional (2-D) echocardiography in the late 1970s and early 1980s that deeply influenced the field. For the first time the congenital defects could be imaged noninvasively and the 2-D images were extensively validated by comparing them with pathological and surgical findings. Adding pulsed, continuous, and colour Doppler data to the 2-D images resulted in a complete detailed description of congenital cardiac defects and their haemodynamic consequences. Further optimization of ultrasound technology specifically for paediatric imaging, such as the development of higher-frequency probes and increasing the standard grey-scale frame rates, further improved spatial and temporal resolution and overall image quality. Based on its excellent diagnostic accuracy and its non-invasive nature, echocardiography quickly became the primary non-invasive diagnostic technique for all children with heart disease. Currently every paediatric patient with suspected heart disease will undergo an echocardiographic examination as the first (and often only) diagnostic test.

scholarly journals Diffraction/Scattering Tomography on multi-phase crystalline/amorphous materials

2014 ◽  
Vol 70 (a1) ◽  
pp. C139-C139 ◽  
Author(s):  
Michelle Alvarez-Murga ◽  
Pierre Bleuet ◽  
Christophe Lepoittevin ◽  
Nathalie Boudet ◽  
Gaston Gabarino ◽  
...  
Keyword(s):  
Amorphous Materials ◽  
Structural Information ◽  
Local Variation ◽  
X Rays ◽  
Complex Materials ◽  
Diffraction Scattering ◽  
Invasive Approach ◽  
Non Invasive ◽  
Phase Selectivity ◽  
Multi Phase

By suitably combining diffraction/scattering and tomography (DSCT), it is possible to access to selective submicron 2D/3D structural and micro-structural information, which cannot be obtained from separate, independent diffraction and tomography experiments. DSCT is used to discriminate between multi-phase crystalline and amorphous materials, especially when the similarities in densities limit the use of other methods. In addition, this method is sensitive to local variation of the crystalline state, texture, grain size or strains inside the object and can allow simultaneous 3D mappings of such properties. The DSCT phase-selectivity can be easily combined with fluorescence and absorption for added chemical and density resolution allowing multi-modal analyses. As samples can be used in their original state, this method can be applied without cutting or polishing them. Moreover the setup can be adapted with specific sample environments in order to monitor phase and microstructure evolution as a function of an externally controlled parameter with a non-invasive approach. After a first report on in 1998 [1], since 2008 capabilities of DSCT have been demonstrated using x-rays on complex materials as diverse as biological tissue, pigments, Portland cements, Carbon-based materials, Uranium-based nuclear fuel, Ni/Al2O3 catalysts or amorphous systems [2]. More recently, the technique has evolved towards quantitative characterization of the microstructure and stress/strain through either Rietveld or Peak Profile analyses and also pair distribution function techniques (PDF) and their application to nanostructured materials [3]. In this poster contribution, we briefly review the principle and methodology of pencil-beam based x-ray DSCT which is two-fold: (i) selective structural imaging and (ii) extraction of selective scattered patterns of ultra-minor phases.

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